Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma

  • Authors:
    • Dongchun Wang
    • Changsong Wang
    • Xin Pi
    • Lei Guo
    • Yue Wang
    • Mingjuan Li
    • Yue Feng
    • Ziwei Lin
    • Wei Hou
    • Enyou Li
  • View Affiliations

  • Published online on: May 20, 2016     https://doi.org/10.3892/br.2016.686
  • Pages: 68-72
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Abstract

Currently, there is no adequate, sensitive, reproducible, specific and noninvasive biomarker that can reliably be used to detect renal cell carcinoma (RCC). Previous studies have elucidated the urinary non‑volatile metabolic profile of RCC. However, whether urinary volatile organic compound (VOC) profiles are able to identify RCC remains to be elucidated. In the present study, urine was collected from 22 patients with RCC and 25 healthy subjects. Principal component analysis and orthogonal partial least square discriminant analysis were used to compare the data of patients and healthy subjects, and preoperative and postoperative patients undergoing radical nephrectomy. In total, 11 VOC biomarkers were elevated in the RCC patients compared to the healthy subjects, which were phenol; decanal; 1,6-dioxacyclododecane-7,12-dione; 1-bromo-1-(3-methyl-1‑pentenylidene)-2,2,3,3-tetramethyl-cyclopropane; nonanal; 3-ethyl-3-methylheptane; isolongifolene-5-ol; 2,5-cyclohexadiene-1,4-dione, 2,6-bis(1,1-dimethylethyl); tetradecane; aniline; and 2,6,10,14-tetramethyl-pentadecane. Three biomarkers were decreased in RCC patients: styrene, 4-heptanone and dimethylsilanediol. In preoperative patients, 2-ethyl‑1‑hexanol and cyclohexanone were elevated, while 6-t-butyl-2,2,9,9-tetramethyl-3,5-decadien-7-yne were decreased when compared to postoperative patients. Compared with the healthy subjects, RCC has a unique VOC profile, suggesting that VOC profiles may be a useful diagnostic assay for RCC.
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July-2016
Volume 5 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Wang D, Wang C, Pi X, Guo L, Wang Y, Li M, Feng Y, Lin Z, Hou W, Li E, Li E, et al: Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma. Biomed Rep 5: 68-72, 2016.
APA
Wang, D., Wang, C., Pi, X., Guo, L., Wang, Y., Li, M. ... Li, E. (2016). Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma. Biomedical Reports, 5, 68-72. https://doi.org/10.3892/br.2016.686
MLA
Wang, D., Wang, C., Pi, X., Guo, L., Wang, Y., Li, M., Feng, Y., Lin, Z., Hou, W., Li, E."Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma". Biomedical Reports 5.1 (2016): 68-72.
Chicago
Wang, D., Wang, C., Pi, X., Guo, L., Wang, Y., Li, M., Feng, Y., Lin, Z., Hou, W., Li, E."Urinary volatile organic compounds as potential biomarkers for renal cell carcinoma". Biomedical Reports 5, no. 1 (2016): 68-72. https://doi.org/10.3892/br.2016.686