Elevated serum levels of two anti-neutrophil cytoplasmic antibodies in a lung cancer patient: A case report
- Authors:
- Shinichiro Okauchi
- Tomohiro Tamura
- Katsunori Kagohashi
- Mio Kawaguchi
- Hiroaki Satoh
View Affiliations
Affiliations: Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310-0015, Japan, Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
- Published online on: September 6, 2016 https://doi.org/10.3892/br.2016.750
-
Pages:
511-513
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Abstract
A 71-year-old woman with arthralgia and lung fibrosis was referred to Mito Kyodo General Hospital (Mito, Japan) for a mass, which was incidentally observed on a chest radiograph. The chest computed tomography scan demonstrated fibrotic lesions in the lower lobes of the lung and a nodule in the left upper lobe. The serum levels of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA) and proteinase 3 (PR3)-ANCA were 60.3 and 7.5 U/ml, respectively. A transbronchial biopsy obtained from the nodule in the left upper lobe of the lung revealed a lung adenocarcinoma and the patient underwent standard upper lobectomy of the left lung. Subsequent to the resection, the serum levels of PR3-ANCA and MPO-ANCA returned to 10.0 and <1.0 U/ml, respectively. Notably, titers of antinuclear antibodies were also decreased during the postoperative course. Although elevated serum ANCA levels are rarely seen in lung cancer, they may be associated with the occurrence of lung cancer in certain patients, as observed in the present case.
View References
|
1
|
Beauvillain C, Delneste Y, Renier G,
Jeannin P, Subra JF and Chevailler A: Antineutrophil cytoplasmic
autoantibodies: how should the biologist manage them? Clin Rev
Allergy Immunol. 35:47–58. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hervier B, Pagnoux C, Agard C, Haroche J,
Amoura Z, Guillevin L and Hamidou MA: French Vasculitis Study
Group: Pulmonary fibrosis associated with ANCA-positive
vasculitides. Retrospective study of 12 cases and review of the
literature. Ann Rheum Dis. 68:404–407. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Yamada H: ANCA: Associated lung fibrosis.
Semin Respir Crit Care Med. 32:322–327. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Davies DJ, Moran JE, Niall JF and Ryan GB:
Segmental necrotising glomerulonephritis with antineutrophil
antibody: possible arbovirus aetiology? Br Med J (Clin Res Ed).
285:6061982. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Arimura Y, Minoshima S, Tanaka U, Fujii A,
Kobayashi M, Nakabayashi K, Kitamoto K and Nagasawa T: Pulmonary
involvement in patients with myeloperoxidase
specific-antineutrophil cytoplasmic antibody. Ryumachi. 35:46–55.
1995.(In Japanese). PubMed/NCBI
|
|
6
|
Homma S, Matsushita H and Nakata K:
Pulmonary fibrosis in myeloperoxidase antineutrophil cytoplasmic
antibody-associated vasculitides. Respirology. 9:190–196. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Gaudin PB, Askin FB, Falk RJ and Jennette
JC: The pathologic spectrum of pulmonary lesions in patients with
anti-neutrophil cytoplasmic autoantibodies specific for
anti-proteinase 3 and anti-myeloperoxidase. Am J Clin Pathol.
104:7–16. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Jennette JC and Falk RJ: Small-vessel
vasculitis. N Engl J Med. 337:1512–1523. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Jennette JC: Antineutrophil cytoplasmic
autoantibody-associated diseases: a pathologist's perspective. Am J
Kidney Dis. 18:164–170. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Edgar JD, Rooney DP, McNamee P and McNeill
TA: An association between ANCA positive renal disease and
malignancy. Clin Nephrol. 40:22–25. 1993.PubMed/NCBI
|
|
11
|
Tatsis E, Reinhold-Keller E, Steindorf K,
Feller AC and Gross WL: Wegener's granulomatosis associated with
renal cell carcinoma. Arthritis Rheum. 42:751–756. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Navarro JF, Quereda C, Rivera M, Navarro
FJ and Ortuño J: Anti-neutrophil cytoplasmic antibody-associated
paraneoplastic vasculitis. Postgrad Med J. 70:373–375. 1994.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Morisako T, Tsuchida F, Nakamura H, Ohishi
S and Matsuoka T: A case of squamous cell carcinoma of the lung
with a high titer of proteinase 3 antineutrophil cytoplasmic
antibody. Nihon Kokyuki Gakkai Zasshi. 44:139–143. 2006.(In
Japanese). PubMed/NCBI
|
