Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure

  • Authors:
    • Gang‑Yong Wu
    • Bai‑Da Xu
    • Ting Wu
    • Xiao‑Ying Wang
    • Tian‑Xiao Wang
    • Xiao Zhang
    • Xiao Wang
    • Yang Xia
    • Gang‑Jun Zong
  • View Affiliations

  • Published online on: September 26, 2016     https://doi.org/10.3892/br.2016.761
  • Pages: 601-606
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Abstract

The aim of the present study was to investigate the correlation between serum parathyroid hormone (PTH) levels and coronary artery calcification (CAC) in patients without renal failure, as well as to determine independent risk factors of CAC score (CACS). A total of 157 patients who underwent coronary computed tomography angiographic examination at the 101th Hospital of the People's Liberation Army between December 2013 and February 2015 were retrospectively evaluated. The correlation between PTH levels and CACS was determined using a Pearson correlation analysis. A receiver operating characteristic (ROC) curve was drawn to determine the best cutoff PTH level for prediction of CAC. The independent association between serum PTH levels and CAC was analyzed by using a logistic regression analysis model with the response variable Be binary class. The results revealed that PTH levels in patients in the CAC group were significantly higher than those of patients in the non‑calcification group. PTH levels were positively correlated with CACS (r=0.288, P<0.001). The ROC curve suggested that a PTH level of ≥31.05 pg/ml was the best cut-off point for the prediction of CAC, with a sensitivity of 80.88%, specificity of 60.67% and an area under the curve of 0.761. After including predictive factors for CAC (gender, age, smoking status, diabetes, hypertension, hyperlipidemia, body mass index, glomerular filtration rate and calcium, phosphorus, calcium‑phosphorus product, magnesium, PTH, total cholesterol, low‑density lipoprotein cholesterol, triglyceride, high‑density lipoprotein cholesterol and C‑reactive protein levels), the odds ratio of the serum PTH levels regarding the prediction of CAC was 1.050 (95% confidence interval, 1.027‑1.074; P<0.001). In conclusion, the present study suggested that serum PTH levels are correlated with CAC in patients without renal failure and may thus be used as a reliable predictor of CAC.
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November-2016
Volume 5 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Wu GY, Xu BD, Wu T, Wang XY, Wang TX, Zhang X, Wang X, Xia Y and Zong GJ: Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure. Biomed Rep 5: 601-606, 2016.
APA
Wu, G., Xu, B., Wu, T., Wang, X., Wang, T., Zhang, X. ... Zong, G. (2016). Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure. Biomedical Reports, 5, 601-606. https://doi.org/10.3892/br.2016.761
MLA
Wu, G., Xu, B., Wu, T., Wang, X., Wang, T., Zhang, X., Wang, X., Xia, Y., Zong, G."Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure". Biomedical Reports 5.5 (2016): 601-606.
Chicago
Wu, G., Xu, B., Wu, T., Wang, X., Wang, T., Zhang, X., Wang, X., Xia, Y., Zong, G."Correlation between serum parathyroid hormone levels and coronary artery calcification in patients without renal failure". Biomedical Reports 5, no. 5 (2016): 601-606. https://doi.org/10.3892/br.2016.761