Evaluation of interferon-induced transmembrane protein-3 (IFITM3) rs7478728 and rs3888188 polymorphisms and the risk of pulmonary tuberculosis

  • Authors:
    • Mohammad Naderi
    • Mohammad Hashemi
    • Fatemeh Abedipour
    • Gholamreza Bahari
    • Maryam Rezaei
    • Mohsen Taheri
  • View Affiliations

  • Published online on: September 29, 2016     https://doi.org/10.3892/br.2016.763
  • Pages: 634-638
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Abstract

The current study aimed to examine the possible association between the interferon‑induced transmembrane protein-3 (IFITM3) gene polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample population. This case‑control study was conducted on 188 PTB patients and 169 healthy subjects. The rs7478728 and rs3888188 variants of IFITM3 were genotyped using polymerase chain reaction‑restriction fragment length polymorphism. The findings showed no significant association between rs7478728 polymorphism and risk of PTB. Regarding rs3888188 polymorphism, the TG genotype as well as G allele significantly increased the risk of PTB [odds ratio (OR)=2.48, 95% confidence interval (CI): 1.42‑4.53; P=0.002, and OR=2.26, 95% CI: 1.33‑3.86; P=0.003, respectively]. In conclusion, the findings revealed that rs3888188 polymorphism increased the risk of PTB in a sample of Iranian population. Additional investigation with larger sample sizes and different ethnicities are needed to verify our findings.
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November-2016
Volume 5 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Naderi M, Hashemi M, Abedipour F, Bahari G, Rezaei M and Taheri M: Evaluation of interferon-induced transmembrane protein-3 (IFITM3) rs7478728 and rs3888188 polymorphisms and the risk of pulmonary tuberculosis. Biomed Rep 5: 634-638, 2016.
APA
Naderi, M., Hashemi, M., Abedipour, F., Bahari, G., Rezaei, M., & Taheri, M. (2016). Evaluation of interferon-induced transmembrane protein-3 (IFITM3) rs7478728 and rs3888188 polymorphisms and the risk of pulmonary tuberculosis. Biomedical Reports, 5, 634-638. https://doi.org/10.3892/br.2016.763
MLA
Naderi, M., Hashemi, M., Abedipour, F., Bahari, G., Rezaei, M., Taheri, M."Evaluation of interferon-induced transmembrane protein-3 (IFITM3) rs7478728 and rs3888188 polymorphisms and the risk of pulmonary tuberculosis". Biomedical Reports 5.5 (2016): 634-638.
Chicago
Naderi, M., Hashemi, M., Abedipour, F., Bahari, G., Rezaei, M., Taheri, M."Evaluation of interferon-induced transmembrane protein-3 (IFITM3) rs7478728 and rs3888188 polymorphisms and the risk of pulmonary tuberculosis". Biomedical Reports 5, no. 5 (2016): 634-638. https://doi.org/10.3892/br.2016.763