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Article

G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco

  • Authors:
    • Wiam Hmimech
    • Brehima Diakite
    • Hind Hassani Idrissi
    • Khalil Hamzi
    • Farah Korchi
    • Dalila Baghdadi
    • Rachida Habbal
    • Sellama Nadifi
  • View Affiliations / Copyright

    Affiliations: Laboratory of Genetics and Molecular Pathology, Medical School, University Hassan II, Casablanca 22000, Morocco, Department of Cardiology, University Hospital Center Ibn Rochd, Casablanca 22000, Morocco
  • Pages: 618-622
    |
    Published online on: September 30, 2016
       https://doi.org/10.3892/br.2016.768
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Abstract

Coagulation factor Leiden mutation has been described as a common genetic risk factor for venous thrombosis; however, this mutation was reported to be practically absent in an African population. Recently, a novel non‑sense mutation in the gene encoding factor V has been associated with the risk of occurrence of cardio‑cerebrovascular diseases such as stroke and venous thrombosis. The aim of the present study was to investigate whether the factor V Leiden (FVL) and C2491T non‑sense mutations are associated with the risk of developing myocardial infarction. Genotyping of FVL and C2491T FV was performed using the polymerase chain reaction restriction fragment length polymorphism method on a sample of 100 patients with myocardial infarction as well as 211 controls. In the study population, the frequency of the FVL mutation was practically zero. However, with regard to the C2491T mutation, the TT genotype was associated with an increased risk of myocardial infarction [odds ratio (OR)=3.16, 95% confidence interval (CI): 1.29‑7.71, P=0.03]. A significant association between the C2491T FV mutation and the risk of myocardial infarction was identified using recessive (OR=2.74, 95% CI: 1.14‑6.58, P=0.04), dominant (OR=1.85, 95% CI: 1.13‑3.04, P=0.02) and additive (OR=1.88, 95% CI: 1.25‑2.80, P=0.004) models. Furthermore, a positive correlation was found between the presence of the C2491T FV mutation and hypertension (P=0.02), which is associated with myocardial infarction. In conclusion, the results of the present study suggested that the C2491T non-sense mutation of the FV gene may be a risk factor for myocardial infarction in a Moroccan population.
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Copy and paste a formatted citation
Spandidos Publications style
Hmimech W, Diakite B, Idrissi HH, Hamzi K, Korchi F, Baghdadi D, Habbal R and Nadifi S: G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco. Biomed Rep 5: 618-622, 2016.
APA
Hmimech, W., Diakite, B., Idrissi, H.H., Hamzi, K., Korchi, F., Baghdadi, D. ... Nadifi, S. (2016). G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco. Biomedical Reports, 5, 618-622. https://doi.org/10.3892/br.2016.768
MLA
Hmimech, W., Diakite, B., Idrissi, H. H., Hamzi, K., Korchi, F., Baghdadi, D., Habbal, R., Nadifi, S."G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco". Biomedical Reports 5.5 (2016): 618-622.
Chicago
Hmimech, W., Diakite, B., Idrissi, H. H., Hamzi, K., Korchi, F., Baghdadi, D., Habbal, R., Nadifi, S."G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco". Biomedical Reports 5, no. 5 (2016): 618-622. https://doi.org/10.3892/br.2016.768
Copy and paste a formatted citation
x
Spandidos Publications style
Hmimech W, Diakite B, Idrissi HH, Hamzi K, Korchi F, Baghdadi D, Habbal R and Nadifi S: G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco. Biomed Rep 5: 618-622, 2016.
APA
Hmimech, W., Diakite, B., Idrissi, H.H., Hamzi, K., Korchi, F., Baghdadi, D. ... Nadifi, S. (2016). G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco. Biomedical Reports, 5, 618-622. https://doi.org/10.3892/br.2016.768
MLA
Hmimech, W., Diakite, B., Idrissi, H. H., Hamzi, K., Korchi, F., Baghdadi, D., Habbal, R., Nadifi, S."G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco". Biomedical Reports 5.5 (2016): 618-622.
Chicago
Hmimech, W., Diakite, B., Idrissi, H. H., Hamzi, K., Korchi, F., Baghdadi, D., Habbal, R., Nadifi, S."G2691A and C2491T mutations of factor V gene and pre-disposition to myocardial infarction in Morocco". Biomedical Reports 5, no. 5 (2016): 618-622. https://doi.org/10.3892/br.2016.768
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