Critical role of calpain in inflammation (Review)

  • Authors:
    • Jingjing Ji
    • Lei Su
    • Zhifeng Liu
  • View Affiliations

  • Published online on: October 19, 2016     https://doi.org/10.3892/br.2016.785
  • Pages: 647-652
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Abstract

Calpains are a family of cysteine proteases, implicated in a wide range of cellular calcium‑regulated functions. Evidence from previous studies using an inhibitor of calpain indicates that calpain activation is involved in the process of numerous inflammation‑associated diseases. As a result of in‑depth studies, calpains have been proposed to influence the process of inflammation via a variety of mechanisms. The aim of the present study is to provide an overview of recent reports regarding the role of calpain in the process of inflammation, including regulation of immune cell migration, modulation of the activation of inflammatory mediators, degradation of certain associated proteins and induction of cell apoptosis. Understanding these mechanisms may contribute to the investigation of novel therapeutic targets for inflammation‑associated diseases.
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December-2016
Volume 5 Issue 6

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Ji J, Su L and Liu Z: Critical role of calpain in inflammation (Review). Biomed Rep 5: 647-652, 2016
APA
Ji, J., Su, L., & Liu, Z. (2016). Critical role of calpain in inflammation (Review). Biomedical Reports, 5, 647-652. https://doi.org/10.3892/br.2016.785
MLA
Ji, J., Su, L., Liu, Z."Critical role of calpain in inflammation (Review)". Biomedical Reports 5.6 (2016): 647-652.
Chicago
Ji, J., Su, L., Liu, Z."Critical role of calpain in inflammation (Review)". Biomedical Reports 5, no. 6 (2016): 647-652. https://doi.org/10.3892/br.2016.785