Association between the rs1805081 polymorphism of Niemann‑Pick type C1 gene and cardiovascular disease in a sample of an Iranian population

  • Authors:
    • Masoumeh Afzali
    • Mohammad Hashemi
    • Seyed Payman Tabatabaei
    • Kourosh Tirgar Fakheri
    • Alireza Nakhaee
  • View Affiliations

  • Published online on: November 7, 2016     https://doi.org/10.3892/br.2016.802
  • Pages: 83-88
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Abstract

The aim of the present study was to investigate the association between a genetic variation, A+644G, in the Niemann‑Pick type C1 (NPC1) gene and the risk of cardiovascular disease (CVD) in a Southeast Iranian population. A total of 320 individuals, including 200 patients with CVD and 120 healthy individuals, were involved in the present study. The polymorphism was determined using a polymerase chain reaction‑restriction fragment length polymorphism method. The results indicated that the frequency of the GG genotype was markedly lower in patients with CVD compared with the control group (7 vs. 16.7%), and that the NPC1 rs1805081 polymorphism was associated with reduced risk of CVD [odds ratio (OR)=0.110; 95% confidence interval (CI)=0.017‑0.715; P=0.021]. In addition, the prevalence of the minor allele (G) in patients with CVD differed from that of the control group with the frequency of 25.5 and 33.4% for the former and latter, respectively, and this difference reached statistical significance (OR=0.658; 95% CI=0.482‑0.971; P=0.037). Furthermore, analysis of clinical characteristics of the individuals according to the NPC1 genotypes revealed an association between the lipid profile and NPC1 gene polymorphism. These findings demonstrated that the NPC1 A+644G variant was associated with reduced risk of CVD and serves a protective role against susceptibility to CVD in the Iranian population.
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January-2017
Volume 6 Issue 1

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Afzali M, Hashemi M, Tabatabaei SP, Fakheri KT and Nakhaee A: Association between the rs1805081 polymorphism of Niemann‑Pick type C1 gene and cardiovascular disease in a sample of an Iranian population. Biomed Rep 6: 83-88, 2017.
APA
Afzali, M., Hashemi, M., Tabatabaei, S.P., Fakheri, K.T., & Nakhaee, A. (2017). Association between the rs1805081 polymorphism of Niemann‑Pick type C1 gene and cardiovascular disease in a sample of an Iranian population. Biomedical Reports, 6, 83-88. https://doi.org/10.3892/br.2016.802
MLA
Afzali, M., Hashemi, M., Tabatabaei, S. P., Fakheri, K. T., Nakhaee, A."Association between the rs1805081 polymorphism of Niemann‑Pick type C1 gene and cardiovascular disease in a sample of an Iranian population". Biomedical Reports 6.1 (2017): 83-88.
Chicago
Afzali, M., Hashemi, M., Tabatabaei, S. P., Fakheri, K. T., Nakhaee, A."Association between the rs1805081 polymorphism of Niemann‑Pick type C1 gene and cardiovascular disease in a sample of an Iranian population". Biomedical Reports 6, no. 1 (2017): 83-88. https://doi.org/10.3892/br.2016.802