Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

Asano,Krisana; Takahashi,Emiko; Yoshimura,Sayuri; Nakane,Akio

doi:10.3892/br.2017.1011

Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice

Authors:
- Krisana Asano
- Emiko Takahashi
- Sayuri Yoshimura
- Akio Nakane
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Affiliations: Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan, Biopolymer and Health Science, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan
Published online on: November 2, 2017 https://doi.org/10.3892/br.2017.1011
Pages: 37-40

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Abstract

Proteoglycan (PG) is a complex glycohydrate that is widely distributed in the extracellular matrix. Oral administration of PG extracted from salmon nasal cartilage has been reported to attenuate the severity and proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen-induced arthritis and obesity-induced inflammation. In the present study, the effects of salmon nasal cartilage PG on skin allografts were investigated in a mouse model. Oral administration of PG prolonged the survival of skin grafts within 10 days of transplantation. Although PG failed to inhibit allograft rejection at the final stage of transplantation, PG attenuated the cell infiltration in the skin under the transplanted site.

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