Open Access

Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment

  • Authors:
    • Guangdong Chen
    • Xiaodong Lin
    • Gongying Li
    • Diego Jiang
    • Zhiruo Lib
    • Ronghuan Jiang
    • Chuanjun Zhuo
  • View Affiliations

  • Published online on: January 27, 2017     https://doi.org/10.3892/br.2017.850
  • Pages: 285-290
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain‑derived neurotrophic factor (BDNF)‑tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK‑801) treatment. In experiment 1, adult male Sprague-Dawley rats subjected to acute treatment of either low‑dose MK801 (0.1 mg/kg) or normal saline (vehicle) were tested for spatial object recognition and hippocampal expression levels of BDNF, TrkB and the phophorylation of TrkB (p‑TrkB). We found that compared to the vehicle, MK‑801 treatment impaired spatial object recognition of animals and downregulated the expression levels of p‑TrkB. In experiment 2, MK‑801‑ or vehicle‑treated animals were further injected with risperidone (0.1 mg/kg) or vehicle before behavioural testing and sacrifice. Of note, we found that risperidone successfully reversed the deleterious effects of MK‑801 on spatial object recognition and upregulated the hippocampal BDNF‑TrkB signalling system. Collectively, the findings suggest that cognitive deficits from acute N‑methyl‑D‑aspartate receptor blockade may be associated with the hypofunction of hippocampal BDNF‑TrkB signalling system and that risperidone was able to reverse these alterations.
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March-2017
Volume 6 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Chen G, Lin X, Li G, Jiang D, Lib Z, Jiang R and Zhuo C: Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomed Rep 6: 285-290, 2017.
APA
Chen, G., Lin, X., Li, G., Jiang, D., Lib, Z., Jiang, R., & Zhuo, C. (2017). Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomedical Reports, 6, 285-290. https://doi.org/10.3892/br.2017.850
MLA
Chen, G., Lin, X., Li, G., Jiang, D., Lib, Z., Jiang, R., Zhuo, C."Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment". Biomedical Reports 6.3 (2017): 285-290.
Chicago
Chen, G., Lin, X., Li, G., Jiang, D., Lib, Z., Jiang, R., Zhuo, C."Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment". Biomedical Reports 6, no. 3 (2017): 285-290. https://doi.org/10.3892/br.2017.850