Association between interleukin-1 receptor associated kinase 1 rs3027898 A/C gene polymorphism and rheumatoid arthritis

Atabaki,Mahdi; Hashemi,Mohammad; Daneshvar,Hamid; Alijani,Ebrahim

doi:10.3892/br.2017.855

Association between interleukin-1 receptor associated kinase 1 rs3027898 A/C gene polymorphism and rheumatoid arthritis

Authors:
- Mahdi Atabaki
- Mohammad Hashemi
- Hamid Daneshvar
- Ebrahim Alijani
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Affiliations: Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167‑43181, Iran, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchestan 98167‑43181, Iran, Department of Immunology, Kerman University of Medical Sciences, Kerman, Kerman 76169‑14115, Iran
Published online on: February 9, 2017 https://doi.org/10.3892/br.2017.855
Pages: 335-338

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Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune disease predominantly involving the synovial joints and affects up to 1% of adults worldwide. The aim of the present study was to determine whether the interleukin-1 receptor (IL1R)-associated kinase (IRAK1) rs3027898 gene polymorphism confers susceptibility to RA in a sample of patients from Iran. This gene encodes IRAK1, one of two putative serine/threonine kinases that associates with IL1R upon stimulation. IRAK1 is partially responsible for IL‑1‑induced upregulation of the transcription factor, nuclear factor‑κB. The present case‑control study was performed on 120 patients with RA and 120 healthy individuals. Genomic DNA was extracted from whole blood, and the gene polymorphism was evaluated using a tetra-primer amplification refractory mutation system-polymerase chain reaction method. The results demonstrated that there was no association between IRAK1 rs3027898 CA genotype and the risk of RA in women (odds ratio=0.72, 95% confidence interval=0.41‑1.49; P=0.446). Further studies with larger sample sizes and different ethnicities are required to validate the present findings.

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