Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)

  • Authors:
    • Amir Sonnenblick
    • Tamar Zahavi
  • View Affiliations

  • Published online on: March 30, 2017     https://doi.org/10.3892/br.2017.882
  • Pages: 545-548
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The long-term prognosis following resection of hepatocellular carcinoma (HCC) remains unsatisfactory as a result of a high incidence of recurrence. Prevention of recurrence is the most important strategy to improve the long-term survival results. The role of hepatectomy itself, as an accelerator of carcinogenesis, has not been adequately evaluated in HCC patients. Studies in animal models have revealed a link between liver regeneration under chronic inflammation and hepatic tumorigenesis. Inhibiting different signal transduction pathways during liver regeneration without compromising the ability of the liver to regenerate appears to be a rational strategy and may decrease HCC development and recurrence. If this hypothesis is proven using animal models, this strategy could be evaluated in future clinical trials in humans.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 6 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sonnenblick A and Sonnenblick A: Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review). Biomed Rep 6: 545-548, 2017
APA
Sonnenblick, A., & Sonnenblick, A. (2017). Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review). Biomedical Reports, 6, 545-548. https://doi.org/10.3892/br.2017.882
MLA
Sonnenblick, A., Zahavi, T."Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)". Biomedical Reports 6.5 (2017): 545-548.
Chicago
Sonnenblick, A., Zahavi, T."Accelerated carcinogenesis following liver resection in chronically inflamed livers: A window of opportunity for treatment (Review)". Biomedical Reports 6, no. 5 (2017): 545-548. https://doi.org/10.3892/br.2017.882