Glucose metabolism before and after radioiodine therapy of a patient with Graves' disease: Assessment by continuous glucose monitoring

  • Authors:
    • Yun Hu
    • Gu Gao
    • Reng‑Na Yan
    • Feng‑Fei Li
    • Xiao‑Fei Su
    • Jian‑Hua Ma
  • View Affiliations

  • Published online on: June 21, 2017     https://doi.org/10.3892/br.2017.932
  • Pages: 183-187
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Abstract

Hyperthyroidism causes impaired glucose tolerance, insulin resistance (IR) and insulin secretion. However, the glucose variability affected by thyroid dysfunction remains unclear. Glucose variability was assessed by continuous glucose monitoring (CGM) in a non‑diabetic patient with Graves' disease (GD), to the best of our knowledge, for the first time. A 28‑year‑old man with GD, who had been taking methimazole for 4 years, was treated with radioiodine on August 17th 2016. Although the patient exhibited normal glycated hemoglobin (HbA1c; 5.3%) and blood glucose values during the oral glucose tolerance test (OGTT; fasting and 120 min blood glucose were 5.38 and 6.39 mmol/l, respectively) before radioiodine therapy, CGM exhibited high 24 h mean glucose and nocturnal hyperglycemia. An increased fasting insulin level, suppressed levels of blood glucagon and high homeostatic model assessment of IR were also observed. The disordered glucose metabolism improved as soon as the patient's thyroid function turned to hypothyroidism 4 months after radioiodine therapy. The glucose intolerance in patients with hyperthyroidism, missed by the OGTT and HbA1c tests, may be more common than anticipated.
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August-2017
Volume 7 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Hu Y, Gao G, Yan RN, Li FF, Su XF and Ma JH: Glucose metabolism before and after radioiodine therapy of a patient with Graves' disease: Assessment by continuous glucose monitoring. Biomed Rep 7: 183-187, 2017
APA
Hu, Y., Gao, G., Yan, R., Li, F., Su, X., & Ma, J. (2017). Glucose metabolism before and after radioiodine therapy of a patient with Graves' disease: Assessment by continuous glucose monitoring. Biomedical Reports, 7, 183-187. https://doi.org/10.3892/br.2017.932
MLA
Hu, Y., Gao, G., Yan, R., Li, F., Su, X., Ma, J."Glucose metabolism before and after radioiodine therapy of a patient with Graves' disease: Assessment by continuous glucose monitoring". Biomedical Reports 7.2 (2017): 183-187.
Chicago
Hu, Y., Gao, G., Yan, R., Li, F., Su, X., Ma, J."Glucose metabolism before and after radioiodine therapy of a patient with Graves' disease: Assessment by continuous glucose monitoring". Biomedical Reports 7, no. 2 (2017): 183-187. https://doi.org/10.3892/br.2017.932