Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

Awadasseid,Annoor; Eugene,Kuugbee; Jamal,Mayada; Hou,Jie; Musa Hago,Ahmed; Gamallat,Yaser; Meyiah,Abdo; Bamba,Djibril; Gift,Chiwala; Abdalla,Mohnad; Ma,Yufang; Xin,Yi

doi:10.3892/br.2017.999

Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

Authors:
- Annoor Awadasseid
- Kuugbee Eugene
- Mayada Jamal
- Jie Hou
- Ahmed Musa Hago
- Yaser Gamallat
- Abdo Meyiah
- Djibril Bamba
- Chiwala Gift
- Mohnad Abdalla
- Yufang Ma
- Yi Xin
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Affiliations: Department of Biotechnology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Geology, University of Kordofan, El-Obeid 51111, Republic of Sudan, Department of Pathology and Pathophysiology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China, Department of Biochemistry and Molecular Biology, School of Life Science, University of Science and Technology of China, Hefei Shi, Anhui 230000, P.R. China, Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning 116044, P.R. China
Published online on: October 11, 2017 https://doi.org/10.3892/br.2017.999
Pages: 567-572

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Abstract

Coriolus versicolor (CV) contains high levels of bioactive compounds, including the glucan (1→6)-α-D-glucopyranosyl. However, there is a lack of data regarding the potential effect of this CV glucan (CVG) on the stimulation of cytokine production. The present study evaluated the effect of CVG on the stimulation of cytokine production in sarcoma-180-bearing mice. Mice were treated with three doses of CVG (40, 100 or 200 mg/kg body weight) for nine days, after which serum levels of cytokines, namely interleukin (IL)-2, -4, -6, -10, -17A and interferon (IFN)-α and -γ, were investigated by ELISA. CVG significantly promoted the secretion of IL-2, -4, -6, -10, -17A and IFN-α and -γ at the doses of 100 (P<0.05) and 200 (P<0.01) mg/kg, but not at 40 mg/kg (P>0.05), when compared with cyclophosphamide treatment, as a positive control. Additionally, cytokine production associated with T helper (Th)2 and Th17 cells was enhanced compared with that of Th1 cytokines, and the immunomodulatory function of CVG appeared to be IL-10-dependent. These results demonstrate that CVG may stimulate the production of cytokines and serve as a Th2/IL-10-dependent immunomodulator, and thus has promise in supporting cancer therapies.

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1	Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B and Percival SS: Consuming Lentinula edodes (Shiitake) mushrooms daily improves human immunity: A randomized dietary intervention in healthy young adults. J Am Coll Nutr. 34:478–487. 2015. View Article : Google Scholar : PubMed/NCBI
2	Esposito P, La Porta E, Calatroni M, Bianzina S, Libetta C, Gregorini M, Rampino T and Dal Canton A: Renal involvement in mushroom poisoning: The case of Orellanus syndrome. Hemodial Int. 19:E1–E5. 2015. View Article : Google Scholar : PubMed/NCBI
3	Awadasseid AHJ, Gamallat Y, Xueqi S, Eugene KD, Musa Hago A, et al: Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor. PloS one. 12:e01712702017. View Article : Google Scholar : PubMed/NCBI
4	Dimitrijevic MV, Mitic VD, Cvetkovic JS, Stankov VPJ, Mutic JJ, Snezana D and Mandic N: Update on element content profiles in eleven wild edible mushrooms from family Boletaceae. Eur Food Res Technol. 242:1–10. 2016. View Article : Google Scholar
5	Ekwemalor K, Asiamah E and Worku M: Effect of a mushroom (Coriolus versicolor) based probiotic on the expression of toll-like receptors and signal transduction in goat neutrophils. J Mol Biol Res. 6:71–79. 2016. View Article : Google Scholar
6	Wahyuningsih SPA, Pramudya M and Sugiharto S: Influence of polysaccharide krestin from Coriolus versicolor extract on nitrite and malondialdehyde concencentrations of Mus musculus serum exposed by Mycobacterium tuberculosis. Biosaintifika. 8:12–17. 2016. View Article : Google Scholar
7	Qin SY, Zhang AQ, Cheng SX, Rong L and Zhang XZ: Drug self-delivery systems for cancer therapy. Biomaterials. 112:234–247. 2017. View Article : Google Scholar : PubMed/NCBI
8	Wang H, Yu J, Lu X and He X: Nanoparticle systems reduce systemic toxicity in cancer treatment. Nanomedicine (Lond). 11:103–106. 2016. View Article : Google Scholar : PubMed/NCBI
9	Wu YL, Zhou L and Lu Y: Intrathecal chemotherapy as a treatment for leptomeningeal metastasis of non-small cell lung cancer: A pooled analysis. Oncol Lett. 12:1301–1314. 2016.PubMed/NCBI
10	Gong Y, Yang C, Yin X, Zhu M, Yang H, Wang Y, Li Y, Liu L, Dong X, Cao S, et al: The effect of essential medicines programme on rational use of medicines in China. Health Policy Plan. 31:21–27. 2016. View Article : Google Scholar : PubMed/NCBI
11	Wang N, Awadasseid A, Yuan Y, Cui J, Guo T, Gou D, Bai Y, Zhou Y and Gao J: Biotransformation of ginsenoside Rb1 for ginsenoside Rd preparation by Lysinibacillus massiliensis No 24. Indian J Biotechnol. 15:400–406. 2016.
12	Elbe S, Roemer-Mahler A and Long C: Medical countermeasures for national security: A new government role in the pharmaceuticalization of society. Soc Sci Med. 131:263–271. 2015. View Article : Google Scholar : PubMed/NCBI
13	Prasad S, Rathore H, Sharma S and Yadav AS: Medicinal mushrooms as a source of novel functional food. Int J Food Sci Nutr Diet. 4:221–225. 2015.
14	Khan MS, Zhang X, You L, Fu X and Abbasi AM: Structure and bioactivities of fungal polysaccharides. Polysaccharides: Bioactivity and Biotechnology. 1–14. 2014. View Article : Google Scholar
15	Habijanic J, Berovic M, Boh B, Plankl M and Wraber B: Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-α, IL-12, IFN-γ, IL-2, IL-4, IL-10 and IL-17. N Biotechnol. 32:85–95. 2015. View Article : Google Scholar : PubMed/NCBI
16	Ali MF, Driscoll CB, Walters PR, Limper AH and Carmona EM: β-glucan-activated human B lymphocytes participate in innate immune responses by releasing proinflammatory cytokines and stimulating neutrophil chemotaxis. J Immunol. 195:5318–5326. 2015. View Article : Google Scholar : PubMed/NCBI
17	Wagener AH, de Nijs SB, Lutter R, Sousa AR, Weersink EJ, Bel EH and Sterk PJ: External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax. 70:115–120. 2015. View Article : Google Scholar : PubMed/NCBI
18	Szymczak I and Pawliczak R: The active metabolite of vitamin D3 as a potential immunomodulator. Scand J Immunol. 83:83–91. 2016. View Article : Google Scholar : PubMed/NCBI
19	Landskron G, De la Fuente M, Thuwajit P, Thuwajit C and Hermoso MA: Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. 2014:1–19. 2014. View Article : Google Scholar
20	Parker BS, Rautela J and Hertzog PJ: Antitumour actions of interferons: Implications for cancer therapy. Nat Rev Cancer. 16:131–144. 2016. View Article : Google Scholar : PubMed/NCBI
21	Khodabandehloo H, Gorgani-Firuzjaee S, Panahi G and Meshkani R: Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction. Transl Res. 167:228–256. 2016. View Article : Google Scholar : PubMed/NCBI
22	Tavakolpour S and Tavakolpour V: Interleukin 4 inhibition as a potential therapeutic in pemphigus. Cytokine. 77:189–195. 2016. View Article : Google Scholar : PubMed/NCBI
23	Martin NT and Martin MU: Interleukin 33 is a guardian of barriers and a local alarmin. Nat Immunol. 17:122–131. 2016. View Article : Google Scholar : PubMed/NCBI
24	Conti P and Kempuraj D: Important role of mast cells in multiple sclerosis. Mult Scler Relat Disord. 5:77–80. 2016. View Article : Google Scholar : PubMed/NCBI
25	Schmidt-Arras D and Rose-John S: IL-6 pathway in the liver: From physiopathology to therapy. J Hepatol. 64:1403–1415. 2016. View Article : Google Scholar : PubMed/NCBI
26	Raggi C, Mousa HS, Correnti M, Sica A and Invernizzi P: Cancer stem cells and tumor-associated macrophages: A roadmap for multitargeting strategies. Oncogene. 35:671–682. 2016. View Article : Google Scholar : PubMed/NCBI
27	Chang WS, Liao CH, Tsai CW, Hu PS, Wu HC, Hsu SW, Ji HX, Hsiao CL and Bau DT: The role of IL-10 promoter polymorphisms in renal cell carcinoma. Anticancer Res. 36:2205–2209. 2016.PubMed/NCBI
28	Cai S, Batra S, Langohr I, Iwakura Y and Jeyaseelan S: IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense. Mucosal Immunol. 9:718–729. 2016. View Article : Google Scholar : PubMed/NCBI
29	Miyazaki Y and Niino M: Endogenous type I interferons and their regulators in multiple sclerosis. Clin Exp Neuroimmunol. 8:17–23. 2017. View Article : Google Scholar
30	Lippitz BE: Cytokine patterns in patients with cancer: A systematic review. Lancet Oncol. 14:e218–e228. 2013. View Article : Google Scholar : PubMed/NCBI
31	Mannino MH, Zhu Z, Xiao H, Bai Q, Wakefield MR and Fang Y: The paradoxical role of IL-10 in immunity and cancer. Cancer Lett. 367:103–107. 2015. View Article : Google Scholar : PubMed/NCBI
32	Snaric J: Link between colorectal cancer and bacteria by Tom Noerper. 2014.
33	Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI