Exosome‑mediated peritoneal dissemination in gastric cancer and its clinical applications (Review)

Chen,Kai‑Bo; Chen,Jian; Jin,Xiao‑Li; Huang,Yi; Su,Qiu‑Ming; Chen,Li

doi:10.3892/br.2018.1088

Exosome‑mediated peritoneal dissemination in gastric cancer and its clinical applications (Review)

Authors:
- Kai‑Bo Chen
- Jian Chen
- Xiao‑Li Jin
- Yi Huang
- Qiu‑Ming Su
- Li Chen
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Affiliations: Department of General Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
Published online on: April 19, 2018 https://doi.org/10.3892/br.2018.1088
Pages: 503-509

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Abstract

The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell‑cell communication. Gastric cancer tumor‑derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial‑to‑mesenchymal transition, angiogenesis and chemoresistance. The present review focuses on previous studies addressing the exosome‑dependent molecular transfer in peritoneal dissemination in gastric cancer and the potential clinical applications.

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