Open Access

The role of high mobility group box 1 protein in acute cerebrovascular diseases (Review)

  • Authors:
    • Shu-Wen Mu
    • Yuan Dang
    • Shou-Sen Wang
    • Jian-Jun Gu
  • View Affiliations

  • Published online on: July 10, 2018     https://doi.org/10.3892/br.2018.1127
  • Pages: 191-197
  • Copyright: © Mu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The occurrence and development of acute cerebrovascular diseases involves an inflammatory response, and high mobility group box protein 1 (HMGB1) is a pro‑inflammatory factor that is expressed not only in the early‑injury stage of disease, but also during the post‑repair process. In the initial stage of disease, HMGB1 is released into the outside of the cell to participate in the cascade amplification reaction of inflammation, causing vasospasm, destruction of the blood‑brain barrier and apoptosis of nerve cells. In the recovery stage of disease, HMGB1 can promote tissue repair and remodeling, which can aid in nerve function recovery. This review summarizes the biological characteristics of HMGB1, and the role of HMGB1 in ischemic and hemorrhagic cerebrovascular disease, and cerebral venous thrombosis.
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September-2018
Volume 9 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Mu S, Dang Y, Wang S and Gu J: The role of high mobility group box 1 protein in acute cerebrovascular diseases (Review). Biomed Rep 9: 191-197, 2018.
APA
Mu, S., Dang, Y., Wang, S., & Gu, J. (2018). The role of high mobility group box 1 protein in acute cerebrovascular diseases (Review). Biomedical Reports, 9, 191-197. https://doi.org/10.3892/br.2018.1127
MLA
Mu, S., Dang, Y., Wang, S., Gu, J."The role of high mobility group box 1 protein in acute cerebrovascular diseases (Review)". Biomedical Reports 9.3 (2018): 191-197.
Chicago
Mu, S., Dang, Y., Wang, S., Gu, J."The role of high mobility group box 1 protein in acute cerebrovascular diseases (Review)". Biomedical Reports 9, no. 3 (2018): 191-197. https://doi.org/10.3892/br.2018.1127