Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review)

Ikeda,Yuka; Murakami,Mutsumi; Nakagawa,Yukie; Tsuji,Ai; Kitagishi,Yasuko; Matsuda,Satoru

doi:10.3892/br.2020.1299

Diet induces hepatocyte protection in fatty liver disease via modulation of PTEN signaling (Review)

Authors:
- Yuka Ikeda
- Mutsumi Murakami
- Yukie Nakagawa
- Ai Tsuji
- Yasuko Kitagishi
- Satoru Matsuda
View Affiliations

Affiliations: Department of Food Science and Nutrition, Nara Women's University, Nara 630‑8506, Japan
Published online on: April 22, 2020 https://doi.org/10.3892/br.2020.1299
Pages: 295-302
Copyright: © Ikeda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fatty liver disease (FLD) is characterized by accumulation of excess fat in the liver. The underlying molecular mechanism associated with the progression of the disease has been in elusive. Hepatocellular demise due to increased oxidative stress resulting in an inflammatory response may be a key feature in FLD. Recent advances in molecular biology have led to an improved understanding of the molecular pathogenesis, suggesting a critical association between the PI3K/AKT/PTEN signaling pathway and FLD. In particular, PTEN has been associated with regulating the pathogenesis of hepatocyte degeneration. Given the function of mitochondria in reactive oxygen species (ROS) generation and the initiation of oxidative stress, the mitochondrial antioxidant network is of interest. It is vital to balance the activity of intracellular key molecules to maintain a healthy liver. Consequently, onset of FLD may be delayed using dietary protective agents that alter PTEN signaling and reduce ROS levels. The advancement of research on dietary regulation with a focus on modulatory roles in ROS generation and PTEN associated signaling is summarized in the current study, supporting further preventive and therapeutic exploration.

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