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Neuroprotective effects of the aerial parts of Polygala tenuifolia Willd extract on scopolamine‑induced learning and memory impairments in mice

  • Authors:
    • Xiao Wang
    • Dian Zhang
    • Weihao Song
    • Cheng Fei Cai
    • Zihao Zhou
    • Qi Fu
    • Xingrong Yan
    • Yanjun Cao
    • Minfeng Fang

  • View Affiliations

  • Published online on: August 19, 2020     https://doi.org/10.3892/br.2020.1344
  • Article Number: 37
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Abstract

Alzheimer's disease is a common neurodegenerative disease characterized by progressive cognitive dysfunction and behavioral impairment. Aerial parts of Polygala tenuifolia Willd (APT) is a traditional Chinese medicine used for the treatment of amnesia. The present study aimed to investigate the protective effects of APT on scopolamine‑induced learning and memory impairments in mice. Scopolamine‑induced mice were used to determine the effects of APT on learning and memory impairment. Mice were orally administered with APT (25, 50 and 100 mg/kg) and piracetam (750 mg/kg) for 14 days, and intraperitoneally injected with scopolamine (2 mg/kg) from days 8 to 14. Morris water maze and step‑down tests were performed to evaluate learning and memory. Levels of acetylcholine (ACh), choline acetyltransferase (ChAT), acetylcholinesterase (AChE), interleukin (IL)‑1β, IL‑10 and brain‑derived neurotrophic factor (BDNF) in the hippocampus and frontal cortex were measured by ELISA. Superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione (GSH) were measured via biochemical detection. The results demonstrated that APT ameliorated learning and memory impairment in scopolamine‑induced mice. Correspondingly, APT significantly increased ACh and ChAT levels in the hippocampus and prefrontal cortex of scopolamine‑induced mice. Additionally, treatment with APT significantly increased BDNF and IL‑10 levels, and decreased IL‑1β and AChE levels in the same mice. Furthermore, APT significantly increased SOD activity and GSH content, and decreased MDA levels in brain tissue. These results indicated that APT may ameliorate learning and memory impairment by regulating cholinergic activity, promoting BDNF and inhibiting neuroinflammation and oxidative stress.
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November-2020
Volume 13 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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  • CiteScore: 4.1
  • CiteScore Rank: Q1: #19/80 Pharmacology, Toxicology and Pharmaceutics
  • Source Normalized Impact per Paper (SNIP): 0.7
  • SCImago Journal Rank (SJR): 0.514
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Spandidos Publications style
Wang X, Zhang D, Song W, Cai CF, Zhou Z, Fu Q, Yan X, Cao Y and Fang M: Neuroprotective effects of the aerial parts of <em>Polygala&nbsp;tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice. Biomed Rep 13: 37, 2020.
APA
Wang, X., Zhang, D., Song, W., Cai, C.F., Zhou, Z., Fu, Q. ... Fang, M. (2020). Neuroprotective effects of the aerial parts of <em>Polygala&nbsp;tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice. Biomedical Reports, 13, 37. https://doi.org/10.3892/br.2020.1344
MLA
Wang, X., Zhang, D., Song, W., Cai, C. F., Zhou, Z., Fu, Q., Yan, X., Cao, Y., Fang, M."Neuroprotective effects of the aerial parts of <em>Polygala&nbsp;tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice". Biomedical Reports 13.5 (2020): 37.
Chicago
Wang, X., Zhang, D., Song, W., Cai, C. F., Zhou, Z., Fu, Q., Yan, X., Cao, Y., Fang, M."Neuroprotective effects of the aerial parts of <em>Polygala&nbsp;tenuifolia</em> Willd extract on scopolamine‑induced learning and memory impairments in mice". Biomedical Reports 13, no. 5 (2020): 37. https://doi.org/10.3892/br.2020.1344