Associations of the MTHFR rs1801133 polymorphism with gastric cancer risk in the Chinese Han population

  • Authors:
    • Zhiqiang Han
    • Huaming Sheng
    • Qiuzhi Gao
    • Yu Fan
    • Xiang Xie
  • View Affiliations

  • Published online on: November 17, 2020     https://doi.org/10.3892/br.2020.1390
  • Article Number: 14
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Abstract

In recent years, increasing evidence has implicated the importance of mutations in the MTHFR gene in the risk of gastric cancer risk. A single nucleotide polymorphism (SNP) in the MTHFR gene (rs1801133) may serve a critical role in gastric cancer. A hospital‑based case‑controlled study was performed to assess the risk of the rs1801133 polymorphism on gastric cancer. A total of 307 patients with gastric cancer and 560 patients in the control group were recruited. Genomic DNA was extracted from peripheral blood and genotyped for rs1801133 using the ligase detection reaction. The relationship between rs1801133 and gastric cancer risk was evaluated by unconditional logistical regression analysis. The rs1801133‑TT genotype was associated with a borderline significantly decreased risk of gastric cancer [(TT vs. CC, adjusted odds ratio (OR)=0.54, 95% confidence intervals (CI)=0.35‑0.83; P=0.006; CT vs. CC, adjusted OR=0.59, 95% CI=0.44‑0.79, P<0.001; and TT/CT vs. CC, adjusted OR=0.61, 95% CI=0.44‑0.83, P=0.001), and further analysis showed the relationship was evident amongst older patients and patients who never drank alcohol. The C>T mutation at rs1801133 of the MTHFR gene was associated with a decreased risk of gastric cancer in older individuals and those who never drink.
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January-2021
Volume 14 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Han Z, Sheng H, Gao Q, Fan Y and Xie X: Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population. Biomed Rep 14: 14, 2021.
APA
Han, Z., Sheng, H., Gao, Q., Fan, Y., & Xie, X. (2021). Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population. Biomedical Reports, 14, 14. https://doi.org/10.3892/br.2020.1390
MLA
Han, Z., Sheng, H., Gao, Q., Fan, Y., Xie, X."Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population". Biomedical Reports 14.1 (2021): 14.
Chicago
Han, Z., Sheng, H., Gao, Q., Fan, Y., Xie, X."Associations of the <em>MTHFR</em> rs1801133 polymorphism with gastric cancer risk in the Chinese Han population". Biomedical Reports 14, no. 1 (2021): 14. https://doi.org/10.3892/br.2020.1390