Potential role of β‑carotene‑modulated autophagy in puerperal breast inflammation (Review)
- Authors:
- Stella Tinia Hasianna
- Julia Windi Gunadi
- Enny Rohmawaty
- Ronny Lesmana
-
Affiliations: Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java 45363, Indonesia, Department of Physiology, Faculty of Medicine, Universitas Kristen Maranatha, Bandung, West Java 40164, Indonesia, Pharmacology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java 45363, Indonesia, Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java 45363, Indonesia - Published online on: July 22, 2022 https://doi.org/10.3892/br.2022.1558
- Article Number: 75
This article is mentioned in:
Abstract
![]() |
![]() |
Silva FV, Dias F, Costa G and Campos MDG: Chamomile reveals to be a potent galactogogue: The unexpected effect. J Matern Neonatal Med. 31:116–118. 2018.PubMed/NCBI View Article : Google Scholar | |
World Health Organization (WHO) and United Nations Children's Fund (UNICEF): Indicators for Assessing Infant and Young Child Feeding Practices. Vol. WHA55 A55/. WHO, Geneva, p122, 2021. http://apps.who.int/iris/bitstream/handle/10665/44306/9789241599290_eng.pdf?sequence=1%0Ahttp://whqlibdoc.who.int/publications/2008/9789241596664_eng.pdf%5Cnhttp://www.unicef.org/programme/breastfeeding/innocenti.htm%5Cnhttp://innocenti15.net/declaration. | |
Mosca F and Giannì ML: Human milk: Composition and health benefits. Pediatr Med Chir. 39(155)2017.PubMed/NCBI View Article : Google Scholar | |
Henrick BM, Nag K, Yao XD, Drannik AG, Aldrovandi GM and Rosenthal KL: Milk matters: Soluble toll-like receptor 2 (sTLR2) in breast milk significantly inhibits HIV-1 infection and inflammation. PLoS One. 7(e40138)2012.PubMed/NCBI View Article : Google Scholar | |
World Health Organization and United Nations Children's Fund (UNICEF): Baby-friendly hospital initiative: revised, updated and expanded for integrated care. WHO, Geneva, 2009. https://apps.who.int/iris/handle/10665/43593. | |
Chang PC, Li SF, Yang HY, Wang LC, Weng CY, Chen KF, Chen W and Fan SY: Factors associated with cessation of exclusive breastfeeding at 1 and 2 months postpartum in Taiwan. Int Breastfeed J. 14(18)2019.PubMed/NCBI View Article : Google Scholar | |
Grzeskowiak LE, Wlodek ME and Geddes DT: What evidence do we have for pharmaceutical galactagogues in the treatment of lactation insufficiency?-a narrative review. Nutrients. 11(974)2019.PubMed/NCBI View Article : Google Scholar | |
Lou Z, Zeng G, Huang L, Wang Y, Zhou L and Kavanagh KF: Maternal reported indicators and causes of insufficient milk supply. J Hum Lact. 30:466–473; quiz 511-2. 2014.PubMed/NCBI View Article : Google Scholar | |
Brown CRL, Dodds L, Legge A, Bryanton J and Semenic S: Factors influencing the reasons why mothers stop breastfeeding. Can J Public Health. 105:e179–e185. 2014.PubMed/NCBI View Article : Google Scholar | |
Grzeskowiak LE, Dalton JA and Fielder AL: Factors associated with domperidone use as a galactogogue at an australian tertiary teaching hospital. J Hum Lact. 31:249–253. 2015.PubMed/NCBI View Article : Google Scholar | |
Riordan J, Bibb D, Miller M and Rawlins T: Predicting breastfeeding duration using the LATCH breastfeeding assessment tool. J Hum Lact. 17:20–23. 2001.PubMed/NCBI View Article : Google Scholar | |
Wöckel A, Abou-Dakn M, Beggel A and Arck P: Inflammatory breast diseases during lactation: Health effects on the newborn-A literature review. Mediators Inflamm. 2008(298760)2008.PubMed/NCBI View Article : Google Scholar | |
Schwartz K, D'Arcy HJ, Gillespie B, Bobo J, Longeway M and Foxman B: Factors associated with weaning in the first 3 months postpartum. J Fam Pract. 51:439–444. 2002.PubMed/NCBI | |
Bond DM, Morris JM and Nassar N: Study protocol: Evaluation of the probiotic Lactobacillus Fermentum CECT5716 for the prevention of mastitis in breastfeeding women: A randomised controlled trial. BMC Pregnancy Childbirth. 17(148)2017.PubMed/NCBI View Article : Google Scholar | |
Pevzner M and Dahan A: Mastitis while breastfeeding: Prevention, the importance of proper treatment, and potential complications. J Clin Med. 9(2328)2020.PubMed/NCBI View Article : Google Scholar | |
Scott JA, Robertson M, Fitzpatrick J, Knight C and Mulholland S: Occurrence of lactational mastitis and medical management: A prospective cohort study in Glasgow. Int Breastfeed J. 3(21)2008.PubMed/NCBI View Article : Google Scholar | |
Cooklin AR, Amir LH, Nguyen CD, Buck ML, Cullinane M, Fisher JRW and Donath SM: CASTLE Study Team. Physical health, breastfeeding problems and maternal mood in the early postpartum: A prospective cohort study. Arch Womens Ment Health. 21:365–374. 2018.PubMed/NCBI View Article : Google Scholar | |
Sordillo LM: Factors affecting mammary gland immunity and mastitis susceptibility. Livest Prod Sci. 98:89–99. 2005. | |
Li C, Solomons NW, Scott ME and Koski KG: Subclinical mastitis (SCM) and proinflammatory cytokines are associated with mineral and trace element concentrations in human breast milk. J Trace Elem Med Biol. 46:55–61. 2018.PubMed/NCBI View Article : Google Scholar | |
Li L, Tan J, Miao Y, Lei P and Zhang Q: ROS and Autophagy: Interactions and molecular regulatory mechanisms. Cell Mol Neurobiol. 35:615–621. 2015.PubMed/NCBI View Article : Google Scholar | |
Yang FL and Li XS: Role of antioxidant vitamins and trace elements in mastitis in dairy cows. J Adv Vet Anim Res. 2:1–9. 2015. | |
Ellah MR: Role of Free Radicals and Antioxidants in Mastitis. J Adv Vet Res. 3:1–7. 2013. | |
Kurnianto D: Inhibitory power of moringa leaf juice (Moringa oleifera) against Staphylococcus aureus and Escherichia coli growth as the etiology of mastitis in cattle (unpublished PhD thesis). Universitas Brawijaya, 2015. | |
Wijayanti D and Ardigurnita F: The development of binahong leaf as an antiseptic to overcome mastitis in dairy cows in the Giri Mukti herd, Tasikmalaya. J-Dinamika Journal of Public Health. 4:148–152. 2019.https://publikasi.polije.ac.id/index.php/j-dinamika/article/view/1087. | |
Kurniawan I, Sarwiyono S and Surjowardojo P: The effect of teat dipping using cherry leaf decoction (Muntingia calabura L.) on the incidence of mastitis. Indonesian Journal of Animal Science. 23:27–31. 2010. | |
Xiao H, Zhao J, Fang C, Cao Q, Xing M, Li X, Hou J, Ji A and Song S: Advances in studies on the pharmacological activities of fucoxanthin. Mar Drugs. 18(634)2020.PubMed/NCBI View Article : Google Scholar | |
Putri SU: Effect of Macroalgae extract on bacteria Staphylococcus aureus and methicillin resistant Staphylococcus aureus (unpublished PhD thesis). Alauddin Islamic State University, 2016. | |
Triandini IGAAH, Ruqqayah S and Astuti NLB: In vitro research on plants as natural antibiotics for breast inflammation (Mastitis). Sangkareang Mataram Scientific Journal. 4(3):14–17. 2018.https://sangkareang.org/index.php/SANGKAREANG/article/view/122. | |
Leblanc SJ, Herdt TH, Seymour WM, Duffield TF and Leslie KE: Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their associations with disease. J Dairy Sci. 87:609–619. 2004.PubMed/NCBI View Article : Google Scholar | |
Chew BP, Hollen LL, Hillers JK and Herlugson ML: Relationship between vitamin A and β-carotene in blood plasma and milk and mastitis in holsteins. J Dairy Sci. 65:2111–2118. 1982.PubMed/NCBI View Article : Google Scholar | |
Heinrichs AJ, Costello SS and Jones CM: Control of heifer mastitis by nutrition. Vet Microbiol. 134:172–176. 2009.PubMed/NCBI View Article : Google Scholar | |
Russo M, Moccia S, Bilotto S, Spagnuolo C, Durante M, Lenucci MS, Mita G, Volpe MG, Aquino RP and Russo GL: A carotenoid extract from a Southern Italian cultivar of pumpkin triggers nonprotective autophagy in malignant cells. Oxid Med Cell Longev. 2017(7468538)2017.PubMed/NCBI View Article : Google Scholar | |
Zielińska MA, Wesołowska A, Pawlus B and Hamułka J: Health effects of carotenoids during pregnancy and lactation. Nutrients. 9(838)2017.PubMed/NCBI View Article : Google Scholar | |
Crackers NR and Per V: USDA National Nutrient Database for Standard Reference. Release 1 (Omega 3). 3:3–7. 2019.https://ods.od.nih.gov/pubs/usdandb/VitA-betaCarotene-Content.pdf. | |
Lesmana R, Felia Yusuf I, Goenawan H, Achadiyani A, Khairani AF, Nur Fatimah S and Supratman U: Low Dose of β-carotene regulates inflammation, reduces caspase signaling, and correlates with autophagy activation in cardiomyoblast cell lines. Med Sci Monit Basic Res. 26(e928648)2020.PubMed/NCBI View Article : Google Scholar | |
Cheng J, Balbuena E, Miller B and Eroglu A: The role of β-carotene in colonic inflammation and intestinal barrier integrity. Front Nutr. 8(723480)2021.PubMed/NCBI View Article : Google Scholar | |
Palozza P: Can beta-carotene regulate cell growth by a redox mechanism? An answer from cultured cells. Biochim Biophys Acta. 1740:215–221. 2005.PubMed/NCBI View Article : Google Scholar | |
Janik IA: The detection and prediction of mastitis in dairy cows by particle analysis (unpublished PhD thesis). Coventry University, 2013. | |
O'Rourke D: Nutrition and udder health in dairy cows: A review. Ir Vet J. 62 (Suppl 4):S15–S20. 2009.PubMed/NCBI View Article : Google Scholar | |
Yang Y, Li R, Hui J, Li L and Zheng X: β-Carotene attenuates LPS-induced rat intestinal inflammation via modulating autophagy and regulating the JAK2/STAT3 and JNK/p38 MAPK signaling pathways. J Food Biochem. 45(e13544)2021.PubMed/NCBI View Article : Google Scholar | |
Zhao G, Zhang X, Wang H and Chen Z: Beta carotene protects H9c2 cardiomyocytes from advanced glycation end product-induced endoplasmic reticulum stress, apoptosis, and autophagy via the PI3K/Akt/mTOR signaling pathway. Ann Transl Med. 8(647)2020.PubMed/NCBI View Article : Google Scholar | |
Mass S: Breast pain: Engorgement, nipple pain and mastitis. Clin Obstet Gynecol. 47:676–682. 2004.PubMed/NCBI View Article : Google Scholar | |
Guo W, Liu B, Yin Y, Kan X, Gong Q, Li Y, Cao Y, Wang J, Xu D, Ma H, et al: Licochalcone A protects the blood milk barrier integrity and relieves the inflammatory response in LPS-Indued mastitis. Front Immunol. 10(287)2019.PubMed/NCBI View Article : Google Scholar | |
Zhu Y, Cheng J, Min Z, Yin T, Zhang R, Zhang W, Hu L, Cui Z, Gao C, Xu S, et al: Effects of fucoxanthin on autophagy and apoptosis in SGC-7901cells and the mechanism. J Cell Biochem. 119:7274–7284. 2018.PubMed/NCBI View Article : Google Scholar | |
Zeng M, Sang W, Chen S, Chen R, Zhang H, Xue F, Li Z, Liu Y, Gong Y, Zhang H and Kong X: 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models. Toxicol Lett. 271:26–37. 2017.PubMed/NCBI View Article : Google Scholar | |
Wang X, Su F, Yu X, Geng N, Li L, Wang R, Zhang M, Liu J, Liu Y and Han B: RNA-Seq whole transcriptome analysis of bovine mammary epithelial cells in response to intracellular staphylococcus aureus. Front Vet Sci. 7(642)2020.PubMed/NCBI View Article : Google Scholar | |
Hou LL, Gao C, Chen L, Hu GQ and Xie SQ: Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells. Acta Pharmacol Sin. 34:1403–1410. 2013.PubMed/NCBI View Article : Google Scholar | |
Scherz-Shouval R and Elazar Z: Regulation of autophagy by ROS: Physiology and pathology. Trends Biochem Sci. 36:30–38. 2011.PubMed/NCBI View Article : Google Scholar | |
He L, He T, Farrar S, Ji L, Liu T and Ma X: Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species. Cell Physiol Biochem. 44:532–553. 2017.PubMed/NCBI View Article : Google Scholar | |
Atakisi O, Oral H, Atakisi E, Merhan O, Metin Pancarci S, Ozcan A, Marasli S, Polat B, Colak A and Kaya S: Subclinical mastitis causes alterations in nitric oxide, total oxidant and antioxidant capacity in cow milk. Res Vet Sci. 89:10–13. 2010.PubMed/NCBI View Article : Google Scholar | |
Mittal M, Siddiqui MR, Tran K, Reddy SP and Malik AB: Reactive oxygen species in inflammation and tissue injury. Antioxidants Redox Signal. 20:1126–1167. 2014.PubMed/NCBI View Article : Google Scholar | |
Cao Y, Wang J, Tian H and Fu GH: Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer. J Exp Clin Cancer Res. 39(119)2020.PubMed/NCBI View Article : Google Scholar | |
Guo W, Li W, Su Y, Liu S, Kan X, Ran X, Cao Y, Fu S and Liu J: GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy. Int J Biol Sci. 17:4271–4284. 2021.PubMed/NCBI View Article : Google Scholar | |
Qian M, Fang X and Wang X: Autophagy and inflammation. Clin Transl Med. 6(24)2017.PubMed/NCBI View Article : Google Scholar | |
Sun Y, Huang YH, Huang FY, Mei WL, Liu Q, Wang CC, Lin YY, Huang C, Li YN, Dai HF and Tan GH: 3'-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells. Theranostics. 8:2044–2060. 2018.PubMed/NCBI View Article : Google Scholar | |
Jung CH, Ro SH, Cao J, Otto NM and Kim DH: MTOR regulation of autophagy. FEBS Lett. 584:1287–1295. 2010.PubMed/NCBI View Article : Google Scholar | |
Chang KC, Liu PF, Chang CH, Lin YC, Chen YJ and Shu CW: The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell Biosci. 12(1)2022.PubMed/NCBI View Article : Google Scholar | |
Hadad N and Levy R: The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling. Free Radic Biol Med. 53:1381–1391. 2012.PubMed/NCBI View Article : Google Scholar | |
Lee H, Lim JW and Kim H: Effect of Astaxanthin on Activation of Autophagy and Inhibition of Apoptosis in Helicobacter pylori-Infected Gastric Epithelial Cell Line AGS. Nutrients. 12(1750)2020.PubMed/NCBI View Article : Google Scholar | |
Jiang GM, Tan Y, Wang H, Peng L, Chen HT, Meng XJ, Li LL, Liu Y, Li WF and Shan H: The relationship between autophagy and the immune system and its applications for tumor immunotherapy. Mol Cancer. 18(17)2019.PubMed/NCBI View Article : Google Scholar | |
Bolisetty S and Jaimes EA: Mitochondria and reactive oxygen species: Physiology and pathophysiology. Int J Mol Sci. 14:6306–6344. 2013.PubMed/NCBI View Article : Google Scholar | |
Martinez J, Malireddi RS, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Guan JL, Tan H, Peng J, et al: Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2, and autophagy proteins. Nat Cell Biol. 17:893–906. 2015.PubMed/NCBI View Article : Google Scholar | |
Shin J, Song MH, Oh JW, Keum YS and Saini RK: Pro-oxidant actions of carotenoids in triggering apoptosis of cancer cells: A review of emerging evidence. Antioxidants (Basel). 9(532)2020.PubMed/NCBI View Article : Google Scholar | |
Filteau SM, Rice AL, Ball JJ, Chakraborty J, Stoltzfus R, de Francisco A and Willumsen JF: Breast milk immune factors in Bangladeshi women supplemented postpartum with retinol or beta-carotene. Am J Clin Nutr. 69:953–958. 1999.PubMed/NCBI View Article : Google Scholar | |
Kasperczyk S, Dobrakowski M, Kasperczyk J, Ostałowska A, Zalejska-Fiolka J and Birkner E: Beta-carotene reduces oxidative stress, improves glutathione metabolism and modifies antioxidant defense systems in lead-exposed workers. Toxicol Appl Pharmacol. 280:36–41. 2014.PubMed/NCBI View Article : Google Scholar | |
Zbyradowski M, Duda M, Wisniewska-Becker A, Heriyanto Rajwa W, Fiedor J, Cvetkovic D, Pilch M and Fiedor L: Triplet-driven chemical reactivity of β-carotene and its biological implications. Nat Commun. 13(2474)2022.PubMed/NCBI View Article : Google Scholar | |
Kim DK, Sim BR, Kim JI and Khang G: Functionalized silk fibroin film scaffold using β-Carotene for cornea endothelial cell regeneration. Colloids Surf B Biointerfaces. 164:340–346. 2018.PubMed/NCBI View Article : Google Scholar | |
Kang H and Kim H: Astaxanthin and β-carotene in Helicobacter pylori-induced gastric inflammation: A mini-review on action mechanisms. J Cancer Prev. 22:57–61. 2017.PubMed/NCBI View Article : Google Scholar | |
McGuire S: WHO guideline: Vitamin A supplementation in pregnant women. Geneva: WHO, 2011; WHO guideline: Vitamin A supplementation in postpartum women. Geneva: WHO, 2011. Adv Nutr. 3:215–216. 2012.PubMed/NCBI View Article : Google Scholar | |
World Health Organization (WHO): Guideline: vitamin A supplementation in postpartum women. WHO, Geneva, 2011. https://apps.who.int/iris/handle/10665/44623. | |
Tanaka T, Shnimizu M and Moriwaki H: Cancer chemoprevention by carotenoids. Molecules. 17:3202–3242. 2012.PubMed/NCBI View Article : Google Scholar | |
Haskell MJ: The challenge to reach nutritional adequacy for vitamin A: β-carotene bioavailability and conversion-evidence in humans. Am J Clin Nutr. 96:1193S–1203S. 2012.PubMed/NCBI View Article : Google Scholar | |
National Institutes of Health (NIH): Vitamin A and carotenoids. NIH, Bethesda, MD, pp1-19, 2022. https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/. Accessed June 1, 2022. | |
Xu J, Zhang J, Mao QF, Wu J and Wang Y: The interaction between autophagy and JAK/STAT3 signaling pathway in tumors. Front Genet. 13(880359)2022.PubMed/NCBI View Article : Google Scholar | |
Kitakaze T, Harada N, Imagita H and Yamaji R: β-carotene increases muscle mass and hypertrophy in the soleus muscle in mice. J Nutr Sci Vitaminol (Tokyo). 61:481–487. 2015.PubMed/NCBI View Article : Google Scholar | |
Geng N, Liu K, Lu J, Xu Y, Wang X, Wang R, Liu J, Liu Y and Han B: Autophagy of bovine mammary epithelial cell induced by intracellular Staphylococcus aureus. J Microbiol. 58:320–329. 2020.PubMed/NCBI View Article : Google Scholar |