Real‑world study of Cerviron<sup>®</sup> vaginal ovules in the treatment of cervical lesions of various etiologies

Petre,Izabella; Sirbu,Daniela Teodora; Petrita,Ramona; Toma,Andreea-Denisa; Peta,Ema; Dimcevici‑Poesina,Florentina

doi:10.3892/br.2023.1618

Real‑world study of Cerviron^® vaginal ovules in the treatment of cervical lesions of various etiologies

Authors:
- Izabella Petre
- Daniela Teodora Sirbu
- Ramona Petrita
- Andreea-Denisa Toma
- Ema Peta
- Florentina Dimcevici‑Poesina
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Affiliations: Discipline of Obstetrics and Gynecology XII, ‘Victor Babes’ University of Medicine and Pharmacy, 300041 Timisoara, Romania, Dr Sirbu Daniela Private Practice, 300269 Timisoara, Romania, Biometrics Unit, MDX Research, 300633 Timisoara, Romania, Pharmacy Unit of Municipal Hospital ‘Dr Karl Diel’ Jimbolia, 305400 Jimbolia, Romania, Quality Assurance, Perfect Care Distribution SRL, 011158 Bucharest, Romania
Published online on: July 7, 2023 https://doi.org/10.3892/br.2023.1618
Article Number: 54
Copyright: © Petre et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical lesions can be caused by pathogens, hormonal changes or by cervical injury. The recommended treatment in all cases is excision. Local re‑epithelialization therapy should be initiated preoperatively and postoperatively. The present study assessed the post‑market performance and tolerability of Cerviron^® ovules in the treatment and management of cervical lesions postoperatively. The study population included 345 participants aged 20‑70 years with either a cervical lesion under treatment or with recent surgical removal of a cervical lesion. The degree of re‑epithelialization of the cervical mucosa was improved in 73.17% of the patients evaluated during routine colposcopy exams and 92.73% of patients recorded no bleeding. When adding Cerviron^® either as monotherapy or in association with other antimicrobials in postoperative care of the cervical ectropion, improved postoperative outcomes such as reduced post‑interventional bleeding and a superior quality of healing were observed. The study and its details are registered in www.clinicaltrials.gov under ID NCT05668806.

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