Open Access

Telomere length as a predictive biomarker in osteoporosis (Review)

  • Authors:
    • Fotios Kakridonis
    • Spyros G. Pneumatikos
    • Elena Vakonaki
    • Aikaterini Berdiaki
    • Manolis N. Tzatzarakis
    • Persefoni Fragkiadaki
    • Demetrios A. Spandidos
    • Stella Baliou
    • Petros Ioannou
    • Eleftheria Hatzidaki
    • Dragana Nikitovic
    • Aristidis Tsatsakis
    • Elias Vasiliadis
  • View Affiliations

  • Published online on: October 3, 2023     https://doi.org/10.3892/br.2023.1669
  • Article Number: 87
  • Copyright: © Kakridonis et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Telomeres are the ends of chromosomes that protect them from DNA damage. There is evidence to suggest that telomere shortening appears with advanced age. Since aging is a significant risk factor for developing age‑related complications, it is plausible that telomere shortening may be involved in the development of osteoporosis. The present review summarizes the potential of telomere shortening as a biomarker for detecting the onset of osteoporosis. For the purposes of the present review, the following scientific databases were searched for relevant articles: PubMed/NCBI, Cochrane Library of Systematic Reviews, Scopus, Embase and Google Scholar. The present review includes randomized and non‑randomized controlled studies and case series involving humans, irrespective of the time of their publication. In six out of the 11 included studies providing data on humans, there was at least a weak association between telomere length and osteoporosis, with the remaining studies exhibiting no such association. As a result, telomere shortening may be used as a biomarker or as part of a panel of biomarkers for tracking the onset and progression of osteoporosis.
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November-2023
Volume 19 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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Spandidos Publications style
Kakridonis F, Pneumatikos SG, Vakonaki E, Berdiaki A, Tzatzarakis MN, Fragkiadaki P, Spandidos DA, Baliou S, Ioannou P, Hatzidaki E, Hatzidaki E, et al: Telomere length as a predictive biomarker in osteoporosis (Review). Biomed Rep 19: 87, 2023
APA
Kakridonis, F., Pneumatikos, S.G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M.N., Fragkiadaki, P. ... Vasiliadis, E. (2023). Telomere length as a predictive biomarker in osteoporosis (Review). Biomedical Reports, 19, 87. https://doi.org/10.3892/br.2023.1669
MLA
Kakridonis, F., Pneumatikos, S. G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M. N., Fragkiadaki, P., Spandidos, D. A., Baliou, S., Ioannou, P., Hatzidaki, E., Nikitovic, D., Tsatsakis, A., Vasiliadis, E."Telomere length as a predictive biomarker in osteoporosis (Review)". Biomedical Reports 19.5 (2023): 87.
Chicago
Kakridonis, F., Pneumatikos, S. G., Vakonaki, E., Berdiaki, A., Tzatzarakis, M. N., Fragkiadaki, P., Spandidos, D. A., Baliou, S., Ioannou, P., Hatzidaki, E., Nikitovic, D., Tsatsakis, A., Vasiliadis, E."Telomere length as a predictive biomarker in osteoporosis (Review)". Biomedical Reports 19, no. 5 (2023): 87. https://doi.org/10.3892/br.2023.1669