Open Access

Effects of tidal volume on physiology and clinical outcomes in patients with one‑lung ventilation undergoing surgery: A meta‑analysis of randomized controlled trials

  • Authors:
    • Jie Jiang
    • Feiping Xia
    • Zhonghua Lu
    • Yuying Tang
    • Haibo Qiu
    • Yi Yang
    • Fengmei Guo
  • View Affiliations

  • Published online on: March 8, 2024     https://doi.org/10.3892/br.2024.1761
  • Article Number: 73
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is no detailed study on how tidal volume (VT) affects patients during one‑lung ventilation (OLV). The present study conducted a meta‑analysis to assess the effect of VT on physiology and clinical outcomes in OLV patients. Databases until February 2023 were retrieved from PubMed, Cochrane Library and Web of Science. Randomized controlled trials comparing the application of low and high VT ventilation in adults with OLV were performed. Demographic variables, VT, physiology, and clinical outcomes were retrieved. The random‑effects model calculated the summary of odds ratios with 95% confidence intervals (CI) and mean difference with standard deviation. A total of 12 studies involving a total of 876 participants met the inclusion criteria. Low VT ventilation was associated with decreased risk of acute lung injury [relative risk 0.50, 95% CI (0.28, 0.88), P=0.02]. Low VT ventilation decreased the driving pressure (ΔP) and peak pressure (Ppeak) and improved arterial oxygen pressure (PaO2)/fraction of inspired oxygen (FiO2). Furthermore, the present study suggested that a significant difference in blood IL‑6 was observed between low and high VT ventilation [mean difference, ‑35.51 pg/ml, 95% CI (‑66.47, ‑4.54 pg/ml), P=0.02]. A decrease in the length of stay at the hospital occurred in the low VT group when set to 4‑5 ml/kg. In the OLV patients, low VT ventilation decreased the risk of acute lung injury, blood IL‑6, ΔP and Ppeak, and improved PaO2/FiO2. Furthermore, when low VT was set to 4‑5 ml/kg, the length of stay at the hospital decreased.
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May-2024
Volume 20 Issue 5

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Spandidos Publications style
Jiang J, Xia F, Lu Z, Tang Y, Qiu H, Yang Y and Guo F: Effects of tidal volume on physiology and clinical outcomes in patients with one‑lung ventilation undergoing surgery: A meta‑analysis of randomized controlled trials. Biomed Rep 20: 73, 2024.
APA
Jiang, J., Xia, F., Lu, Z., Tang, Y., Qiu, H., Yang, Y., & Guo, F. (2024). Effects of tidal volume on physiology and clinical outcomes in patients with one‑lung ventilation undergoing surgery: A meta‑analysis of randomized controlled trials. Biomedical Reports, 20, 73. https://doi.org/10.3892/br.2024.1761
MLA
Jiang, J., Xia, F., Lu, Z., Tang, Y., Qiu, H., Yang, Y., Guo, F."Effects of tidal volume on physiology and clinical outcomes in patients with one‑lung ventilation undergoing surgery: A meta‑analysis of randomized controlled trials". Biomedical Reports 20.5 (2024): 73.
Chicago
Jiang, J., Xia, F., Lu, Z., Tang, Y., Qiu, H., Yang, Y., Guo, F."Effects of tidal volume on physiology and clinical outcomes in patients with one‑lung ventilation undergoing surgery: A meta‑analysis of randomized controlled trials". Biomedical Reports 20, no. 5 (2024): 73. https://doi.org/10.3892/br.2024.1761