A comprehensive assessment of toxoplasmosis and its dormant impact on psychotic disorders (Review)

Mares,Aliss Madalina; Varlam,Corina Ioana; Iliuta,Floris Petru; Lacau,Radu Mihail; Manea,Mihnea Costin

doi:10.3892/br.2024.1774

A comprehensive assessment of toxoplasmosis and its dormant impact on psychotic disorders (Review)

Authors:
- Aliss Madalina Mares
- Corina Ioana Varlam
- Floris Petru Iliuta
- Radu Mihail Lacau
- Mihnea Costin Manea
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Affiliations: Department of Psychiatry and Psychology, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 010221 Bucharest, Romania, Department of Psychiatry, ‘Prof. Dr. Alexandru Obregia’ Clinical Hospital of Psychiatry, 041914 Bucharest, Romania
Published online on: April 8, 2024 https://doi.org/10.3892/br.2024.1774
Article Number: 86
Copyright: © Mares et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Toxoplasmosis is a pathological condition induced by the parasite, Toxoplasma gondii (T. gondii), which has a notable affinity for the cellular components of the central nervous system. Over the decades, the relationship between toxoplasmosis and the development of psychiatric disorders has generated profound interest within the scientific community. Whether considering immunocompetent or immunocompromised patients, epidemiological studies suggest that exposure to T. gondii may be associated with a higher risk of certain psychiatric disorders. However, there are extensive debates regarding the exact nature of this association and how T. gondii is involved in the pathogenesis of these disorders. Toxoplasmosis has long been considered an asymptomatic infection among immunocompetent patients. However, there appears to be an association between chronic brain infection with T. gondii and alterations in patient neuronal architecture, neurochemistry and behavior. The present review aimed to compile statements and pathophysiological hypotheses regarding the potential association between toxoplasmosis and psychotic disorders. Further research is necessary for understanding the potential relationship of T. gondii infection and psychotic disorders.

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