Open Access

Predictive factors and symptom severity spectrum in adult schizophrenia: Potential insights for improved management and adequate care

  • Authors:
    • Floris Petru Iliuta
    • Mihnea Costin Manea
    • Andreea Teodorescu
    • Radu-Mihail Lacau
    • Mirela Manea
    • Aliss Madalina Mares
    • Corina Ioana Varlam
    • Constantin Alexandru Ciobanu
    • Adela Magdalena Ciobanu
  • View Affiliations

  • Published online on: July 16, 2024     https://doi.org/10.3892/br.2024.1820
  • Article Number: 132
  • Copyright: © Iliuta et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Schizophrenia is one of the most disabling psychiatric disorders characterized by positive (hallucinations, delusions, formal thinking disorder) and negative symptoms (anhedonia, lack of speech and motivation). The present study aimed to identify the predictive factors of schizophrenia in adults, and potential differences in the environment of origin, sex, levels of occupational stress, intellectual level, marital status and age of onset of the disease depending on the severity of symptoms using analysis of data collected from 120 patients with a diagnosis of schizophrenia. The study was conducted at the ‘Prof. Dr. Alexandru Obregia’ Clinical Psychiatric Hospital in Bucharest and included adult patients hospitalized between March 2018 and January 2021 diagnosed with schizophrenia and evaluated by general clinical examination, psychiatric, neurological and psychological evaluation. Results revealed that robust predictors of mild and moderate symptoms were affective symptoms, heredo‑collateral history of schizophrenia, late onset, the presence of positive and negative symptoms, substance abuse, stress and marital status, unmarried, lower IQ and mental deficiency. For moderate‑severe and severe symptoms, predictors were affective symptoms, heredo‑collateral history of schizophrenia and affective disorders, substance abuse, stress, borderline IQ and mild mental deficiency. The present results can be used for further development of psychopharmacological management of schizophrenia.
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Spandidos Publications style
Iliuta FP, Manea MC, Teodorescu A, Lacau R, Manea M, Mares AM, Varlam CI, Ciobanu CA and Ciobanu AM: Predictive factors and symptom severity spectrum in adult schizophrenia: Potential insights for improved management and adequate care. Biomed Rep 21: 132, 2024.
APA
Iliuta, F.P., Manea, M.C., Teodorescu, A., Lacau, R., Manea, M., Mares, A.M. ... Ciobanu, A.M. (2024). Predictive factors and symptom severity spectrum in adult schizophrenia: Potential insights for improved management and adequate care. Biomedical Reports, 21, 132. https://doi.org/10.3892/br.2024.1820
MLA
Iliuta, F. P., Manea, M. C., Teodorescu, A., Lacau, R., Manea, M., Mares, A. M., Varlam, C. I., Ciobanu, C. A., Ciobanu, A. M."Predictive factors and symptom severity spectrum in adult schizophrenia: Potential insights for improved management and adequate care". Biomedical Reports 21.3 (2024): 132.
Chicago
Iliuta, F. P., Manea, M. C., Teodorescu, A., Lacau, R., Manea, M., Mares, A. M., Varlam, C. I., Ciobanu, C. A., Ciobanu, A. M."Predictive factors and symptom severity spectrum in adult schizophrenia: Potential insights for improved management and adequate care". Biomedical Reports 21, no. 3 (2024): 132. https://doi.org/10.3892/br.2024.1820