Open Access

Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome

  • Authors:
    • Alexander Lopez‑Roblero
    • Eleazar Serrano‑Guzmán
    • Rocío Stephania Guerrero‑Báez
    • Iván Delgado‑Enciso
    • Saúl Gómez‑Manzo
    • Javier Aguilar‑Fuentes
    • Vivían Ovando‑Garay
    • Beatriz Hernández‑Ochoa
    • Iliana Concepción Quezada‑Cruz
    • Noe Lopez‑Lopez
    • Luis Miguel Canseco‑Ávila
  • View Affiliations

  • Published online on: August 20, 2024     https://doi.org/10.3892/br.2024.1838
  • Article Number: 150
  • Copyright: © Lopez‑Roblero et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute coronary syndrome (ACS) is a leading cause of mortality worldwide. Several studies have shown that certain single nucleotide polymorphisms (SNPs) are linked to the development of ACS. In particular, C‑reactive protein (CRP) has emerged as an important predictive biomarker for cardiovascular disease. The current study aimed to investigate four polymorphisms of the CRP gene as possible biomarkers for ACS in a sample of 252 individuals (114 patients with ACS and 138 healthy controls) from Southeastern Mexico. Multivariate analysis adjusted for clinical variables showed that the polymorphism 3872CT for the genotype CC/CT [adjusted Odds Ratio (AdOR)=3.78; 95% Confidence Interval (CI): 1.11‑12.92; P=0.034] and the genotype GG/GC of the polymorphisms 2667CG (AdOR=4.82; 95% CI: 1.69‑13.72; P=0.02) were associated with ACS. However, the polymorphisms 3006AC genotype AA/AC and 5237GA genotype GG/GC were not found to be associated in the multivariate analysis with ACS (P>0.05). These results suggested that 3872CC/CT and 2667CC/CG polymorphism of the CRP gene plays a significant role in the development of ACS.
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November-2024
Volume 21 Issue 5

Print ISSN: 2049-9434
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Spandidos Publications style
Lopez‑Roblero A, Serrano‑Guzmán E, Guerrero‑Báez R, Delgado‑Enciso I, Gómez‑Manzo S, Aguilar‑Fuentes J, Ovando‑Garay V, Hernández‑Ochoa B, Quezada‑Cruz I, Lopez‑Lopez N, Lopez‑Lopez N, et al: Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome. Biomed Rep 21: 150, 2024.
APA
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J. ... Canseco‑Ávila, L. (2024). Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome. Biomedical Reports, 21, 150. https://doi.org/10.3892/br.2024.1838
MLA
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J., Ovando‑Garay, V., Hernández‑Ochoa, B., Quezada‑Cruz, I., Lopez‑Lopez, N., Canseco‑Ávila, L."Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome". Biomedical Reports 21.5 (2024): 150.
Chicago
Lopez‑Roblero, A., Serrano‑Guzmán, E., Guerrero‑Báez, R., Delgado‑Enciso, I., Gómez‑Manzo, S., Aguilar‑Fuentes, J., Ovando‑Garay, V., Hernández‑Ochoa, B., Quezada‑Cruz, I., Lopez‑Lopez, N., Canseco‑Ávila, L."Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome". Biomedical Reports 21, no. 5 (2024): 150. https://doi.org/10.3892/br.2024.1838