Single‑nucleotide polymorphisms in the promoter of the gene encoding for C‑reactive protein associated with acute coronary syndrome
- Authors:
- Alexander Lopez‑Roblero
- Eleazar Serrano‑Guzmán
- Rocío Stephania Guerrero‑Báez
- Iván Delgado‑Enciso
- Saúl Gómez‑Manzo
- Javier Aguilar‑Fuentes
- Vivían Ovando‑Garay
- Beatriz Hernández‑Ochoa
- Iliana Concepción Quezada‑Cruz
- Noe Lopez‑Lopez
- Luis Miguel Canseco‑Ávila
-
Affiliations: Diagnostic and Molecular Biomedicine Laboratory, Faculty of Chemistry Sciences, Campus IV, Autonomous University of Chiapas, Tapachula, Chiapas 30700, México, Cancerology State Institute, Colima State Health Services, Colima 28085, México, Genetic Biochemistry Laboratory, National Institute of Pediatrics, Ministry of Health, México City 04530, México, Faculty of Agricultural Sciences, Autonomous University of Chiapas, Huehuetán, Chiapas 30660, México, Faculty of Medicine, Campus IV, Autonomous University of Chiapas, Tapachula, Chiapas 30700, México, Immunochemistry Laboratory, Children's Hospital of México Federico Gómez, Ministry of Health, México City 06720, México, Faculty of Chemistry Sciences, Campus IV, Autonomous University of Chiapas, Tapachula, Chiapas 30700, México - Published online on: August 20, 2024 https://doi.org/10.3892/br.2024.1838
- Article Number: 150
-
Copyright: © Lopez‑Roblero et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Birnbaum Y, Wilson JM, Fiol M, de Luna AB A, Eskola M and Nikus K: ECG diagnosis and classification of acute coronary syndromes. Ann Noninvasive Electrocardiol. 19:4–14. 2014.PubMed/NCBI View Article : Google Scholar | |
Crea F and Liuzzo G: Pathogenesis of acute coronary syndromes. J Am Coll Cardiol. 61:1–11. 2013.PubMed/NCBI View Article : Google Scholar | |
Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, et al: Israrci ST-segment yükselmesi belirtileri göstermeyen hastalarda akut koronersendromlarin (AKS) tedavi kilavuzlari. Turk Kardiyol Dern Ars. 39:73–128. 2011. | |
Sanchis-Gomar F, Perez-Quilis C, Leischik R and Lucia A: Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med. 4(256)2016.PubMed/NCBI View Article : Google Scholar | |
INEGI: Techninal note on statistics of registered deaths. 2021. Mexico, 2022. Available at: https://www.inegi.org.mx/contenidos/programas/mortalidad/doc/defunciones_registradas_2021_nota_tecnica.pdf. | |
Katsioupa M, Kourampi I, Oikonomou E, Tsigkou V, Theofilis P, Charalambous G, Marinos G, Gialamas I, Zisimos K, Anastasiou A, et al: Novel biomarkers and their role in the diagnosis and prognosis of acute coronary syndrome. Life (Basel). 13(1992)2023.PubMed/NCBI View Article : Google Scholar | |
Momiyama Y, Ohmori R, Fayad ZA, Kihara T, Tanaka N, Kato R, Taniguchi H, Nagata M, Nakamura H and Ohsuzu F: Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis. J Atheroscler Thromb. 17:460–467. 2010.PubMed/NCBI View Article : Google Scholar | |
Szmitko PE, Wang CH, Weisel RD, de Almeida JR, Anderson TJ and Verma S: New markers of inflammation and endothelial cell activation: Part I. Circulation. 108:1917–1923. 2003.PubMed/NCBI View Article : Google Scholar | |
Gupta S, Gupta VK, Gupta R, Arora S and Gupta V: Relationship of high-sensitive C-reactive protein with cardiovascular risk factors, clinical presentation and angiographic profile in patients with acute coronary syndrome: An Indian perspective. Indian Heart J. 65:359–365. 2013.PubMed/NCBI View Article : Google Scholar | |
Casas JP, Shah T, Hingorani AD, Danesh J and Pepys MB: C-reactive protein and coronary heart disease: A critical review. J Intern Med. 264:295–314. 2008.PubMed/NCBI View Article : Google Scholar | |
Eklund CM: Proinflammatory cytokines in CRP baseline regulation. Adv Clin Chem. 48:111–136. 2009.PubMed/NCBI View Article : Google Scholar | |
Pai JK, Mukamal KJ, Rexrode KM and Rimm EB: C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies. PLoS One. 3(e1395)2008.PubMed/NCBI View Article : Google Scholar | |
Rios DL, Cerqueira CC, Bonfim-Silva R, Araújo LJ, Pereira JF, Gadelha SR and Barbosa AA: Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians. Cytokine. 50:292–296. 2010.PubMed/NCBI View Article : Google Scholar | |
Tonet AC, Karnikowski M, Moraes CF, Gomez L, Karnikowski MGO, Córdova C and Nóbrega OT: Association between the-174 G/C promoter polymorphism of the interleukin-6 gene and cardiovascular disease risk factors in Brazilian older women. Braz J Med Biol Res. 41:47–53. 2008.PubMed/NCBI View Article : Google Scholar | |
Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, Sharma P, Lowe GD, World MJ, Humphries SE and Hingorani AD: Human CRP gene polymorphism influences CRP levels: Implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol. 23:2063–2069. 2003.PubMed/NCBI View Article : Google Scholar | |
Kovacs A, Green F, Hansson LO, Lundman P, Samnegård A, Boquist S, Ericsson CG, Watkins H, Hamsten A and Tornvall P: A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein. Atherosclerosis. 178:193–198. 2005.PubMed/NCBI View Article : Google Scholar | |
Volanakis JE: Human C-reactive protein: Expression, structure, and function. Mol Immunol. 38:189–197. 2001.PubMed/NCBI View Article : Google Scholar | |
NACB LMPG Committee Members. Myers GL, Christenson RH, Cushman M, Ballantyne CM, Cooper GR, Pfeiffer CM, Grundy SM, Labarthe DR, Levy D, et al: National academy of clinical biochemistry laboratory medicine practice guidelines: Emerging biomarkers for primary prevention of cardiovascular disease. Clin Chem. 55:378–384. 2009.PubMed/NCBI View Article : Google Scholar | |
Wang XH, Liu SQ, Wang YL and Jin Y: Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome. Genet Mol Res. 13:4260–4266. 2014.PubMed/NCBI View Article : Google Scholar | |
Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, Peden JF, Erdmann J, Braund P, Engert JC, Bennett D, et al: Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA. 302:37–48. 2009.PubMed/NCBI View Article : Google Scholar | |
Zee RYL and Ridker PM: Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis. Atherosclerosis. 162:217–219. 2002.PubMed/NCBI View Article : Google Scholar | |
Liu C, Jin P, Luo Y, Xu J, Kong C, Chen J, Xie H and Zhou G: Association of single-nucleotide polymorphisms of C-reactive protein gene with susceptibility to infantile sepsis in Southern China. Med Sci Monit. 24:590–595. 2018.PubMed/NCBI View Article : Google Scholar | |
Lange LA, Carlson CS, Hindorff LA, Lange EM, Walston J, Durda JP, Cushman M, Bis JC, Zeng D, Lin D, et al: Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events. JAMA. 296:2703–2711. 2006.PubMed/NCBI View Article : Google Scholar | |
Cannon CP, Brindis RG, Chaitman BR, Cohen DJ, Cross JT Jr, Drozda JP Jr, Fesmire FM, Fintel DJ, Fonarow GC, Fox KA, et al: 2013 ACCF/AHA key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes and coronary artery disease: A report of the American college of cardiology foundation/American heart association task force on clinical data standards (writing committee to develop acute coronary syndromes and coronary artery disease clinical data standards). Circulation. 127:1052–1089. 2013.PubMed/NCBI View Article : Google Scholar | |
Carlson CS, Aldred SF, Lee PK, Tracy RP, Schwartz SM, Rieder M, Liu K, Williams OD, Iribarren C, Lewis EC, et al: Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet. 77:64–77. 2005.PubMed/NCBI View Article : Google Scholar | |
Zhao Y, Wang H, Liu S, Zhao X, Chen Y, Yang Y, Wang W, Wu Y, Chen A, Tang J, et al: Association study of CRP gene polymorphism and hypertension in Han Chinese population. Gene. 512:41–46. 2013.PubMed/NCBI View Article : Google Scholar | |
Jebur HB, Masroor M, Ahmad H, Khan NA, Akther J, Bharali D, Singh VK, Verma A, Khan S, Khan V, et al: CRP gene polymorphism and their risk association with type 2 diabetes mellitus. Open Access Maced J Med Sci. 7:33–37. 2018.PubMed/NCBI View Article : Google Scholar | |
Wei W, Yang S, Qiu Y, Wang H, Zhao X, Zhao Y, Li Y, Wu M, Chen Y, Wang W, et al: CRP gene polymorphism contributes genetic susceptibility to dyslipidemia in Han Chinese population. Mol Biol Rep. 41:2335–2343. 2014.PubMed/NCBI View Article : Google Scholar | |
Todendi PF, Klinger EI, Ferreira MB, Reuter CP, Burgos MS, Possuelo LG and Valim AR: Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents. An Acad Bras Cienc. 87:915–924. 2015.PubMed/NCBI View Article : Google Scholar | |
Solé X, Guinó E, Valls J, Iniesta R and Moreno V: SNPStats: A web tool for the analysis of association studies. Bioinformatics. 22:1928–1929. 2006.PubMed/NCBI View Article : Google Scholar | |
Libby P: Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med. 368:2004–2013. 2013.PubMed/NCBI View Article : Google Scholar | |
Hackam DG and Anand SS: Emerging risk factors for atherosclerotic vascular disease: A critical review of the evidence. JAMA. 290:932–940. 2003.PubMed/NCBI View Article : Google Scholar | |
Miller DT, Zee RY, Suk Danik J, Kozlowski P, Chasman DI, Lazarus R, Cook NR, Ridker PM and Kwiatkowski DJ: Association of common CRP gene variants with CRP levels and cardiovascular events. Ann Hum Genet. 69:623–638. 2005.PubMed/NCBI View Article : Google Scholar | |
Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, Lowe GDO, Pepys MB and Gudnason V: C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 350:1387–1397. 2004.PubMed/NCBI View Article : Google Scholar | |
Greenland P, Knoll MD, Stamler J, Neaton JD, Dyer AR, Garside DB and Wilson PW: Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA. 290:891–897. 2003.PubMed/NCBI View Article : Google Scholar | |
Schulz S, Rehm S, Schlitt A, Lierath M, Lüdike H, Hofmann B, Bitter K and Reichert S: C-reactive protein level and the genetic variant rs1130864 in the CRP gene as prognostic factors for 10-year cardiovascular outcome. Cells. 12(1775)2023.PubMed/NCBI View Article : Google Scholar | |
Task Force on diabetes, pre-diabetes and cardiovascular diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD). Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, et al: ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD-summary. Diabetes Vasc Dis Res. 11:133–173. 2014.PubMed/NCBI View Article : Google Scholar | |
Babes EE, Bustea C, Behl T, Abdel-Daim MM, Nechifor AC, Stoicescu M, Brisc CM, Moisi M, Gitea D, Iovanovici DC, et al: Acute coronary syndromes in diabetic patients, outcome, revascularization, and antithrombotic therapy. Biomed Pharmacother. 148(112772)2022.PubMed/NCBI View Article : Google Scholar | |
Reynoso-Villalpando GL, Padilla-Gutiérrez JR, Valdez-Haro A, Casillas-Muñoz F, Muñoz-Valle JF, Castellanos-Nuñez E, Chávez-Herrera JC and Valle Y: Relationship between C-reactive protein serum concentration and the 1846 C>T (rs1205) polymorphism in patients with acute coronary syndrome from Western Mexico. Genet Test Mol Biomarkers. 21:334–340. 2017.PubMed/NCBI View Article : Google Scholar | |
Suk Danik J, Chasman DI, Cannon CP, Miller DT, Zee RY, Kozlowski P, Kwiatkowski DJ and Ridker PM: Influence of genetic variation in the C-reactive protein gene on the inflammatory response during and after acute coronary ischemia. Ann Hum Genet. 70:705–716. 2006.PubMed/NCBI View Article : Google Scholar | |
Kardys I, de Maat MP, Uitterlinden AG, Hofman A and Witteman JC: C-reactive protein gene haplotypes and risk of coronary heart disease: The rotterdam study. Eur Heart J. 27:1331–1337. 2006.PubMed/NCBI View Article : Google Scholar | |
Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, Pfeffer MA and Braunwald E: Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy. N Engl J Med. 352:20–28. 2005. | |
Russell AI, Cunninghame Graham DS, Shepherd C, Roberton CA, Whittaker J, Meeks J, Powell RJ, Isenberg DA, Walport MJ and Vyse TJ: Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus. Hum Mol Genet. 13:137–147. 2004.PubMed/NCBI View Article : Google Scholar | |
Hernández-Díaz Y, Tovilla-Zárate CA, Juárez-Rojop I, Baños-González MA, Torres-Hernández ME, López-Narváez ML, Yañez-Rivera TG and González-Castro TB: The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: Systematic review and meta-analysis. Int J Clin Exp Med. 15:11958–11984. 2015.PubMed/NCBI | |
Grammer TB, März W, Renner W, Böhm BO and Hoffmann MM: C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study. Eur Heart J. 30:170–182. 2009.PubMed/NCBI View Article : Google Scholar | |
Schulz S, Lüdike H, Lierath M, Schlitt A, Werdan K, Hofmann B, Gläser C, Schaller HG and Reichert S: C-reactive protein levels and genetic variants of CRP as prognostic markers for combined cardiovascular endpoint (cardiovascular death, death from stroke, myocardial infarction, and stroke/TIA). Cytokine. 88:71–76. 2016.PubMed/NCBI View Article : Google Scholar | |
Chen Z, Yu D, Xu ZW, Li SS, Li XF, Li J and Yang X: C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke. Neurol Res. 37:979–984. 2015.PubMed/NCBI View Article : Google Scholar | |
Lee CC, You NC, Song Y, Hsu YH, Manson J, Nathan L, Tinker L and Liu S: Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: Findings from the women's health initiative observational cohort. Clin Chem. 55:351–360. 2009.PubMed/NCBI View Article : Google Scholar | |
Markt SC, Rider JR, Penney KL, Schumacher FR, Epstein MM, Fall K, Sesso HD, Stampfer MJ and Mucci LA: Genetic variation across C-reactive protein and risk of prostate cancer. Prostate. 74:1034–1042. 2014.PubMed/NCBI View Article : Google Scholar | |
Chen XL, Liao YQ and Liu JR: Genotype CC of rs1800947 in the C-reactive protein gene may increase susceptibility to colorectal cancer: a meta-analysis. Asian Pac J Cancer Prev. 15:2663–2667. 2014.PubMed/NCBI View Article : Google Scholar | |
Kuhlenbaeumer G, Huge A, Berger K, Kessler C, Voelzke H, Funke H, Stoegbauer F, Stoll M and Ringelstein EB: Genetic variants in the C-reactive protein gene are associated with microangiopathic ischemic stroke. Cerebrovasc Dis. 30:476–482. 2010.PubMed/NCBI View Article : Google Scholar | |
Dai DF, Chiang FT, Lin JL, Huang LY, Chen CL, Chang CJ, Lai LP, Hsu KL, Tseng CD, Tseng YZ and Hwang JJ: Human C-reactive protein (CRP) gene 1059G>C polymorphism is associated with plasma CRP concentration in patients receiving coronary angiography. J Formos Med Assoc. 106:347–354. 2007.PubMed/NCBI View Article : Google Scholar | |
Kolz M, Koenig W, Müller M, Andreani M, Greven S, Illig T, Khuseyinova N, Panagiotakos D, Pershagen G, Salomaa V, et al: DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: Results from the AIRGENE study. Eur Heart J. 29:1250–1258. 2008.PubMed/NCBI View Article : Google Scholar | |
Rizzello V, Liuzzo G, Giannuario GD, Trabetti E, Brugaletta S, Santamaria M, Piro M, Pignatti PF, Maseri A, Biasucci LM and Crea F: 1059G/C polymorphism within the exon 2 of the C-reactive protein gene: Relationship to C-reactive protein levels and prognosis in unstable angina. Coron Artery Dis. 18:533–538. 2007.PubMed/NCBI View Article : Google Scholar | |
Slatkin M: Linkage disequilibrium-understanding the evolutionary past and mapping the medical future. Nat Rev Genet. 9:477–485. 2008.PubMed/NCBI View Article : Google Scholar | |
Martínez-Cortés G, Salazar-Flores J, Fernández-Rodríguez LG, Rubi-Castellanos R, Rodríguez-Loya C, Velarde-Félix JS, Muñoz-Valle JF, Parra-Rojas I and Rangel-Villalobos H: Admixture and population structure in Mexican-Mestizos based on paternal lineages. J Hum Genet. 57:568–574. 2012.PubMed/NCBI View Article : Google Scholar | |
Obisesan TO, Leeuwenburgh C, Phillips T, Ferrell RE, Phares DA, Prior SJ and Hagberg JM: C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arterioscler Thromb Vasc Biol. 24:1874–1879. 2004.PubMed/NCBI View Article : Google Scholar | |
Wang Q, Hunt SC, Xu Q, Chen YE, Province MA, Eckfeldt JH, Pankow JS and Song Q: Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI family heart study. Am J Physiol Heart Circ Physiol. 291:H2752–H2757. 2006.PubMed/NCBI View Article : Google Scholar | |
Szalai AJ, Wu J, Lange EM, McCrory MA, Langefeld CD, Williams A, Zakharkin SO, George V, Allison DB, Cooper GS, et al: Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level. J Mol Med (Berl). 83:440–447. 2005.PubMed/NCBI View Article : Google Scholar | |
Shipe ME, Deppen SA, Farjah F and Grogan EL: Developing prediction models for clinical use using logistic regression: An overview. J Thorac Dis. 11 (Suppl 4):S574–S584. 2019.PubMed/NCBI View Article : Google Scholar | |
Van Smeden M, de Groot JAH, Moons KG, Collins GS, Altman DG, Eijkemans MJ and Reitsma JB: No rationale for 1 variable per 10 events criterion for binary logistic regression analysis. BMC Med Res Methodol. 16(163)2016.PubMed/NCBI View Article : Google Scholar | |
Van Smeden M, Moons KG, de Groot JA, Collins GS, Altman DG, Eijkemans MJ and Reitsma JB: Sample size for binary logistic prediction models: Beyond events per variable criteria. Stat Methods Med Res. 28:2455–2474. 2019.PubMed/NCBI View Article : Google Scholar |