Open Access

Non‑obstructive mesenteric ischaemia during drug therapy for maxillary cancer: A case report

  • Authors:
    • Atsushi Ikeda
    • Shinichi Yamada
    • Risa Ishizaka
    • Kotaro Sakurai
    • Danki Takatsuka
    • Mayu Takaichi
    • Kumiko Fujiwara
    • Makoto Noguchi
  • View Affiliations

  • Published online on: September 19, 2024     https://doi.org/10.3892/br.2024.1860
  • Article Number: 172
  • Copyright: © Ikeda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑occlusive mesenteric ischaemia (NOMI) refers to irreversible intestinal ischaemia and necrosis in the absence of organic obstruction to the mesenteric blood vessels. In cases of delayed diagnosis, the prognosis is poor and the mortality rate is 58‑70%, being the highest among patients with acute mesenteric ischaemia. The risk factors for this disease include heart disease, sepsis, and administration of catecholamines and digitalis; however, there are few reports of its onset during drug therapy for malignant tumours. The present study reported the case of an 85‑year‑old man who developed NOMI during drug therapy for maxillary cancer. The patient was diagnosed with right maxillary carcinoma, for which paclitaxel, carboplatin and cetuximab (PCE) therapy was administered. Four days after starting the second course of PCE therapy, the patient visited the emergency department of our hospital with chief complaints of melena and abdominal pain. Contrast‑enhanced computed tomography revealed ischaemia from the transverse to the descending colon, leading to a diagnosis of NOMI. Colectomy and colostomy were performed during the emergency surgery on the same day. Although the patient's general condition improved, he was transferred to a recuperation facility for palliative care.
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December-2024
Volume 21 Issue 6

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Spandidos Publications style
Ikeda A, Yamada S, Ishizaka R, Sakurai K, Takatsuka D, Takaichi M, Fujiwara K and Noguchi M: Non‑obstructive mesenteric ischaemia during drug therapy for maxillary cancer: A case report. Biomed Rep 21: 172, 2024.
APA
Ikeda, A., Yamada, S., Ishizaka, R., Sakurai, K., Takatsuka, D., Takaichi, M. ... Noguchi, M. (2024). Non‑obstructive mesenteric ischaemia during drug therapy for maxillary cancer: A case report. Biomedical Reports, 21, 172. https://doi.org/10.3892/br.2024.1860
MLA
Ikeda, A., Yamada, S., Ishizaka, R., Sakurai, K., Takatsuka, D., Takaichi, M., Fujiwara, K., Noguchi, M."Non‑obstructive mesenteric ischaemia during drug therapy for maxillary cancer: A case report". Biomedical Reports 21.6 (2024): 172.
Chicago
Ikeda, A., Yamada, S., Ishizaka, R., Sakurai, K., Takatsuka, D., Takaichi, M., Fujiwara, K., Noguchi, M."Non‑obstructive mesenteric ischaemia during drug therapy for maxillary cancer: A case report". Biomedical Reports 21, no. 6 (2024): 172. https://doi.org/10.3892/br.2024.1860