Open Access

Oral food challenge test results of patients with food allergy with specific IgE levels >100 UA/ml

  • Authors:
    • Yusuke Sasaki
    • Kunihiro Matsunami
    • Masashi Kondo
    • Eiji Matsukuma
    • Atsushi Imamura
    • Hideo Kaneko
  • View Affiliations

  • Published online on: September 30, 2024     https://doi.org/10.3892/br.2024.1866
  • Article Number: 178
  • Copyright: © Sasaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Specific IgE level (sIgE) is an important factor indicating sensitization status in children with food allergies (FAs). The present study aimed to clarify oral food challenge test (OFC) results in children with FAs with sIgE levels ≥100 UA/ml compared with those in children with sIgE <100. The retrospective study analyzed patients who underwent OFC with egg white, cow milk and wheat at Gifu Prefectural general medical center, Gifu, Japan between July 2017 and March 2023. Clinical history, total IgE (tIgE), sIgE and correlation between sIgE, sIgE/tIgE and eliciting dose as the amount of intake protein were examined. In the <100 group, positive OFC showed significantly higher sIgE for egg white, ovomucoid and casein than negative OFC (P<0.05); however, there was no significant difference between positive and negative OFC in the ≥100 group. In the <100 group, positive OFC showed significantly higher sIgE/tIgE for ovomucoid, milk and casein than negative OFC (P<0.05); however, there was no significant difference in sIgE/tIgE between positive and negative OFC in the ≥100 group. There was a significant negative correlation between eliciting dose and sIgE for egg white and wheat (P<0.05). For milk and wheat, there was no significant difference between ≥100 group and the <100 group with regard to positive rates in the OFC. Therefore, OFC may be safely performed by decreasing total challenge dose for the ≥100 group.
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Spandidos Publications style
Sasaki Y, Matsunami K, Kondo M, Matsukuma E, Imamura A and Kaneko H: Oral food challenge test results of patients with food allergy with specific IgE levels &gt;100 UA/ml. Biomed Rep 21: 178, 2024.
APA
Sasaki, Y., Matsunami, K., Kondo, M., Matsukuma, E., Imamura, A., & Kaneko, H. (2024). Oral food challenge test results of patients with food allergy with specific IgE levels &gt;100 UA/ml. Biomedical Reports, 21, 178. https://doi.org/10.3892/br.2024.1866
MLA
Sasaki, Y., Matsunami, K., Kondo, M., Matsukuma, E., Imamura, A., Kaneko, H."Oral food challenge test results of patients with food allergy with specific IgE levels &gt;100 UA/ml". Biomedical Reports 21.6 (2024): 178.
Chicago
Sasaki, Y., Matsunami, K., Kondo, M., Matsukuma, E., Imamura, A., Kaneko, H."Oral food challenge test results of patients with food allergy with specific IgE levels &gt;100 UA/ml". Biomedical Reports 21, no. 6 (2024): 178. https://doi.org/10.3892/br.2024.1866