Effect of infusion time on risk of <em>Bacillus cereus</em> bloodstream infections in patients administered with BFLUID amino acid infusions via peripheral venous catheters

Takano,Atsushi; Nakamaru,Yuta; Sako,Ken-Ichi; Takano,Asuka; Iga,Masanori; Machida,Mitsuru; Kaku,Teppei; Ishimura,Atsushi; Nakasuga,Hirotaka; Matsuda,Yoshikazu; Fujikake,Yoshio; Maeda,Tomoji

doi:10.3892/br.2024.1895

Effect of infusion time on risk of Bacillus cereus bloodstream infections in patients administered with BFLUID amino acid infusions via peripheral venous catheters

This article is part of the special Issue: Advance in detection, diagnosis and treatment of infectious diseases
Authors:
- Atsushi Takano
- Yuta Nakamaru
- Ken-Ichi Sako
- Asuka Takano
- Masanori Iga
- Mitsuru Machida
- Teppei Kaku
- Atsushi Ishimura
- Hirotaka Nakasuga
- Yoshikazu Matsuda
- Yoshio Fujikake
- Tomoji Maeda
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Affiliations: Department of Pharmacy, Saitama Red Cross Hospital, Saitama 330‑8553, Japan, Department of Clinical Pharmacy, Nihon Pharmaceutical University, Saitama 362‑0806, Japan
Published online on: November 21, 2024 https://doi.org/10.3892/br.2024.1895
Article Number: 17
Copyright: © Takano et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Comprehensive electrolyte infusions containing amino acids, including BFLUID, are a source of nosocomial infections caused by Bacillus cereus. It is recommended that clinicians finish the administration of BFLUID within 6 h; however, this recommendation currently lacks supporting empirical evidence. Accordingly, the present study aimed to investigate the risk of B. cereus infection associated with BFLUID infusion according to the administration time. In the present single‑center retrospective observational cohort study, clinical information was extracted from the medical records of patients aged ≥18 years who received BFLUID infusions via a peripheral line between April 2017 and October 2020 at Saitama Red Cross Hospital (Saitama, Japan). A total of 96 patients were enrolled during the study period, of whom 32 developed B. cereus infection. No patients with BFLUID infusions administered within 6 h developed B. cereus infection. Compared with patients who received BFLUID infusions within 8 h, those who received BFLUID infusions after 8 h had a 7‑fold higher risk of infection. The present study provided empirical evidence supporting the recommendation that amino acid infusions should be administered to patients within 6 h to minimize the risk of B. cereus infection.

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