Open Access

The roles and functions of TMEM protein family members in cancers, cardiovascular and kidney diseases (Review)

  • Authors:
    • Haosen Xu
    • Shanzhi Yang
    • Peimin Liu
    • Yan Zhang
    • Ting Zhang
    • Jinyi Lan
    • Huan Jiang
    • Danfeng Wu
    • Jiaoqing Li
    • Xiaoyan Bai
  • View Affiliations

  • Published online on: February 11, 2025     https://doi.org/10.3892/br.2025.1941
  • Article Number: 63
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Transmembrane protein (TMEM) is a type of membrane proteins, encoded by TMEM gene, also known as integral membrane protein. TMEM gene family contains various members and its encoded proteins have various functions and expressed in numerous organs. It has been proved to be widely involved in the formation of a lot of organelle membranes, enzymes, receptors and channels, mediating numerous normal physiological functions and regulating various disease processes. At present, accumulating evidences at home and abroad have shown that TMEM is involved in regulating the occurrence and development of different tumors, cardiovascular and kidney diseases. The improved understanding of molecular mechanisms of TMEM genes and proteins may provide new directions and ideas for the prevention, diagnosis and treatment of diseases. In the present review, the roles of TMEM and biological functions in various cancers, cardiovascular and kidney diseases were discussed.
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April-2025
Volume 22 Issue 4

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Copy and paste a formatted citation
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Spandidos Publications style
Xu H, Yang S, Liu P, Zhang Y, Zhang T, Lan J, Jiang H, Wu D, Li J, Bai X, Bai X, et al: The roles and functions of TMEM protein family members in cancers, cardiovascular and kidney diseases (Review). Biomed Rep 22: 63, 2025.
APA
Xu, H., Yang, S., Liu, P., Zhang, Y., Zhang, T., Lan, J. ... Bai, X. (2025). The roles and functions of TMEM protein family members in cancers, cardiovascular and kidney diseases (Review). Biomedical Reports, 22, 63. https://doi.org/10.3892/br.2025.1941
MLA
Xu, H., Yang, S., Liu, P., Zhang, Y., Zhang, T., Lan, J., Jiang, H., Wu, D., Li, J., Bai, X."The roles and functions of TMEM protein family members in cancers, cardiovascular and kidney diseases (Review)". Biomedical Reports 22.4 (2025): 63.
Chicago
Xu, H., Yang, S., Liu, P., Zhang, Y., Zhang, T., Lan, J., Jiang, H., Wu, D., Li, J., Bai, X."The roles and functions of TMEM protein family members in cancers, cardiovascular and kidney diseases (Review)". Biomedical Reports 22, no. 4 (2025): 63. https://doi.org/10.3892/br.2025.1941