Drenkard E and Ausubel FM: Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature. 416:740–743. 2002.PubMed/NCBI View Article : Google Scholar

Behzadi P, Gajdács M, Pallós P, Ónodi B, Stájer A, Matusovits D, Kárpáti K, Burián K, Battah B, Ferrari M, et al: Relationship between biofilm-formation, phenotypic virulence factors and antibiotic resistance in environmental Pseudomonas aeruginosa. Pathogens. 11(1015)2022.PubMed/NCBI View Article : Google Scholar

Chen C, Liao X, Jiang H, Zhu H, Yue L, Li S, Fang B and Liu Y: Characteristics of Escherichia coli biofilm production, genetic typing, drug resistance pattern and gene expression under aminoglycoside pressures. Environ Toxicol Pharmacol. 30:5–10. 2010.PubMed/NCBI View Article : Google Scholar

Sanderson AR, Leid JG and Hunsaker D: Bacterial biofilms on the sinus mucosa of human subjects with chronic rhinosinusitis. Laryngoscope. 116:1121–1126. 2006.PubMed/NCBI View Article : Google Scholar

Mohammed RQ and Abdullah PB: Infection with acute otitis media caused by Pseudomonas aeruginosa (MDR) and Staphylococcus aureus (MRSA). Biochem Cell Arch. 20:905–908. 2020.

Bendouah Z, Barbeau J, Hamad WA and Desrosiers M: Biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa is associated with an unfavorable evolution after surgery for chronic sinusitis and nasal polyposis. Otolaryngol Head Neck Surg. 134:991–996. 2006.PubMed/NCBI View Article : Google Scholar

Carradori S, Di Giacomo N, Lobefalo M, Luisi G, Campestre C and Sisto F: Biofilm and quorum sensing inhibitors: The road so far. Expert Opin Ther Pat. 30:917–930. 2020.PubMed/NCBI View Article : Google Scholar

Wang Y, Bian Z and Wang Y: Biofilm formation and inhibition mediated by bacterial quorum sensing. Appl Microbiol Biotechnol. 106:6365–6381. 2022.PubMed/NCBI View Article : Google Scholar

Zhou L, Zhang Y, Ge Y, Zhu X and Pan J: Regulatory mechanisms and promising applications of quorum sensing-inhibiting agents in control of bacterial biofilm formation. Front Microbiol. 11(589640)2020.PubMed/NCBI View Article : Google Scholar

Ridyard KE and Overhage J: The potential of human peptide LL-37 as an antimicrobial and anti-biofilm agent. Antibiotics (Basel). 10(650)2021.PubMed/NCBI View Article : Google Scholar

Martínez M, Polizzotto A, Flores N, Semorile L and Maffía PC: Antibacterial, anti-biofilm and in vivo activities of the antimicrobial peptides P5 and P6.2. Microb Pathog. 139(103886)2020.PubMed/NCBI View Article : Google Scholar

Paes Leme RC and da Silva RB: Antimicrobial activity of non-steroidal anti-inflammatory drugs on biofilm: Current evidence and potential for drug repurposing. Front Microbiol. 12(707629)2021.PubMed/NCBI View Article : Google Scholar

Schelz Z, Muddather HF and Zupkó I: Repositioning of HMG-CoA reductase inhibitors as adjuvants in the modulation of efflux pump-mediated bacterial and tumor resistance. Antibiotics (Basel). 12(1468)2023.PubMed/NCBI View Article : Google Scholar

Kumar A, Alam A, Grover S, Pandey S, Tripathi D, Kumari M, Rani M, Singh A, Akhter Y, Ehtesham NZ and Hasnain SE: Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention. NPJ Biofilms Microbiomes. 5(3)2019.PubMed/NCBI View Article : Google Scholar

Sauer K, Stoodley P, Goeres DM, Hall-Stoodley L, Burmølle M, Stewart PS and Bjarnsholt T: The biofilm life cycle: Expanding the conceptual model of biofilm formation. Nat Rev Microbiol. 20:608–620. 2022.PubMed/NCBI View Article : Google Scholar

Irie Y, Borlee BR, O'Connor JR, Hill PJ, Harwood CS, Wozniak DJ and Parsek MR: Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa. Proc Natl Acad Sci USA. 109:20632–20636. 2012.PubMed/NCBI View Article : Google Scholar

Parastan R, Kargar M, Solhjoo K and Kafilzadeh F: Staphylococcus aureus biofilms: Structures, antibiotic resistance, inhibition, and vaccines. Gene Rep. 20(100739)2020.

Galli J, Calò L, Ardito F, Imperiali M, Bassotti E, Fadda G and Paludetti G: Biofilm formation by Haemophilus influenzae isolated from adeno-tonsil tissue samples, and its role in recurrent adenotonsillitis. Acta Otorhinolaryngol Ital. 27:134–138. 2007.PubMed/NCBI

Davenport EK, Call DR and Beyenal H: Differential protection from tobramycin by extracellular polymeric substances from Acinetobacter baumannii and Staphylococcus aureus biofilms. Antimicrob Agents Chemother. 58:4755–4761. 2014.PubMed/NCBI View Article : Google Scholar

Serra DO, Klauck G and Hengge R: Vertical stratification of matrix production is essential for physical integrity and architecture of macrocolony biofilms of Escherichia coli. Environ Microbiol. 17:5073–5088. 2015.PubMed/NCBI View Article : Google Scholar

Parsek MR and Greenberg EP: Acyl-homoserine lactone quorum sensing in gram-negative bacteria: A signaling mechanism involved in associations with higher organisms. Proc Natl Acad Sci USA. 97:8789–8793. 2000.PubMed/NCBI View Article : Google Scholar

Singh GB, Malhotra S, Yadav SC, Kaur R, Kwatra D and Kumar S: The role of biofilms in chronic otitis media-active squamosal disease: An evaluative study. Otol Neurotol. 42:e1279–e1285. 2021.PubMed/NCBI View Article : Google Scholar

Dar D, Dar N, Cai L and Newman DK: Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution. Science. 373(eabi4882)2021.PubMed/NCBI View Article : Google Scholar

Cornforth DM, Dees JL, Ibberson CB, Huse HK, Mathiesen IH, Kirketerp-Møller K, Wolcott RD, Rumbaugh KP, Bjarnsholt T and Whiteley M: Pseudomonas aeruginosa transcriptome during human infection. Proc Natl Acad Sci USA. 115:E5125–E5134. 2018.PubMed/NCBI View Article : Google Scholar

Dal Co A, Van Vliet S and Ackermann M: Emergent microscale gradients give rise to metabolic cross-feeding and antibiotic tolerance in clonal bacterial populations. Philos Trans R Soc Lond B Biol Sci. 374(20190080)2019.PubMed/NCBI View Article : Google Scholar

Boase S, Foreman A, Cleland E, Tan L, Melton-Kreft R, Pant H, Hu FZ, Ehrlich GD and Wormald PJ: The microbiome of chronic rhinosinusitis: Culture, molecular diagnostics and biofilm detection. BMC Infect Dis. 13(210)2013.PubMed/NCBI View Article : Google Scholar

Kostić M, Ivanov M, Babić SS, Tepavčević Z, Radanović O, Soković M and Ćirić A: Analysis of tonsil tissues from patients diagnosed with chronic tonsillitis-microbiological profile, biofilm-forming capacity and histology. Antibiotics (Basel). 11(1747)2022.PubMed/NCBI View Article : Google Scholar

Lee MR, Pawlowski KS, Luong A, Furze AD and Roland PS: Biofilm presence in humans with chronic suppurative otitis media. Otolaryngol Head Neck Surg. 141:567–571. 2009.PubMed/NCBI View Article : Google Scholar

Hoa M, Syamal M, Schaeffer MA, Sachdeva L, Berk R and Coticchia J: Biofilms and chronic otitis media: An initial exploration into the role of biofilms in the pathogenesis of chronic otitis media. Am J Otolaryngol. 31:241–245. 2010.PubMed/NCBI View Article : Google Scholar

Karthikeyan P and Nirmal Coumare V: Incidence and presentation of fungal sinusitis in patient diagnosed with chronic rhinosinusitis. Indian J Otolaryngol Head Neck Surg. 62:381–385. 2010.PubMed/NCBI View Article : Google Scholar

Bahethi R, Talmor G, Choudhry H, Lemdani M, Singh P, Patel R and Hsueh W: Chronic invasive fungal rhinosinusitis and granulomatous invasive fungal sinusitis: A systematic review of symptomatology and outcomes. Am J Otolaryngol. 45(104064)2024.PubMed/NCBI View Article : Google Scholar

Yang SW, Luo CM and Cheng TC: Fungal abscess of anterior nasal septum complicating maxillary sinus fungal ball rhinosinusitis caused by Aspergillus flavus: Case report and review of literature. J Fungi (Basel). 10(497)2024.PubMed/NCBI View Article : Google Scholar

Leszczyńska J, Stryjewska-Makuch G, Lisowska G, Kolebacz B and Michalak-Kolarz M: Fungal sinusitis among patients with chronic rhinosinusitis who underwent endoscopic sinus surgery. Otolaryngol Pol. 72:35–41. 2018.PubMed/NCBI View Article : Google Scholar

Marom T, Habashi N, Cohen R and Tamir SO: Role of biofilms in post-tympanostomy tube otorrhea. Ear Nose Throat J. 99 (1 Suppl):22S–29S. 2020.PubMed/NCBI View Article : Google Scholar

Manasherob R, Mooney JA, Lowenberg DW, Bollyky PL and Amanatullah DF: Tolerant small-colony variants form prior to resistance within a Staphylococcus aureus biofilm based on antibiotic selective pressure. Clin Orthop Relat Res. 479:1471–1481. 2021.PubMed/NCBI View Article : Google Scholar

Habashi N, Marom T, Steinberg D, Zacks B and Tamir SO: Biofilm distribution on tympanostomy tubes: An ex vivo descriptive study. Int J Pediatr Otorhinolaryngol. 138(110350)2020.PubMed/NCBI View Article : Google Scholar

Mah TF, Pitts B, Pellock B, Walker GC, Stewart PS and O'Toole GA: A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature. 426:306–310. 2003.PubMed/NCBI View Article : Google Scholar

Kvist M, Hancock V and Klemm P: Inactivation of efflux pumps abolishes bacterial biofilm formation. Appl Environ Microbiol. 74:7376–7382. 2008.PubMed/NCBI View Article : Google Scholar

Tang M, Wei X, Wan X, Ding Z, Ding Y and Liu J: The role and relationship with efflux pump of biofilm formation in Klebsiella pneumoniae. Microb Pathog. 147(104244)2020.PubMed/NCBI View Article : Google Scholar

Powell LC, Abdulkarim M, Stokniene J, Yang QE, Walsh TR, Hill KE, Gumbleton M and Thomas DW: Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. NPJ Biofilms Microbiomes. 7(13)2021.PubMed/NCBI View Article : Google Scholar

Kosztołowicz T and Metzler R: Diffusion of antibiotics through a biofilm in the presence of diffusion and absorption barriers. Phys Rev E. 102(032408)2020.PubMed/NCBI View Article : Google Scholar

Tuon FF, Dantas LR, Suss PH and Tasca Ribeiro VST: Pathogenesis of the Pseudomonas aeruginosa biofilm: A review. Pathogens. 11(300)2022.PubMed/NCBI View Article : Google Scholar

Denton O, Wan Y, Beattie L, Jack T, McGoldrick P, McAllister H, Mullan C, Douglas CM and Shu W: Understanding the role of biofilms in acute recurrent tonsillitis through 3D bioprinting of a novel gelatin-PEGDA hydrogel. Bioengineering (Basel). 11(202)2024.PubMed/NCBI View Article : Google Scholar

Huang Y, Qin F, Li S, Yin J, Hu L, Zheng S, He L, Xia H, Liu J and Hu W: The mechanisms of biofilm antibiotic resistance in chronic rhinosinusitis: A review. Medicine (Baltimore). 101(e32168)2022.PubMed/NCBI View Article : Google Scholar

Abu Bakar M, McKimm J, Haque SZ, Majumder MAA and Haque M: Chronic tonsillitis and biofilms: A brief overview of treatment modalities. J Inflam Res. 11:329–337. 2018.PubMed/NCBI View Article : Google Scholar

Schilder AGM, Chonmaitree T, Cripps AW, Rosenfeld RM, Casselbrant ML, Haggard MP and Venekamp RP: Otitis media. Nat Rev Dis Primers. 2(16063)2016.PubMed/NCBI View Article : Google Scholar

Duff AF, Jurcisek JA, Kurbatfinski N, Chiang T, Goodman SD, Bakaletz LO and Bailey MT: Oral and middle ear delivery of otitis media standard of care antibiotics, but not biofilm-targeted antibodies, alter chinchilla nasopharyngeal and fecal microbiomes. NPJ Biofilms Microbiomes. 10(10)2024.PubMed/NCBI View Article : Google Scholar

Niedzielski A, Chmielik LP and Stankiewicz T: The formation of biofilm and bacteriology in otitis media with effusion in children: A prospective cross-sectional study. Int J Environ Res Public Health. 18(3555)2021.PubMed/NCBI View Article : Google Scholar

Abdelhady W, Bayer AS, Seidl K, Moormeier DE, Bayles KW, Cheung AL, Yeaman MR and Xiong YQ: Impact of vancomycin on sarA-mediated biofilm formation: Role in persistent endovascular infections due to methicillin-resistant Staphylococcus aureus. J Infect Dis. 209:1231–1240. 2014.PubMed/NCBI View Article : Google Scholar

Rose WE and Poppens PT: Impact of biofilm on the in vitro activity of vancomycin alone and in combination with tigecycline and rifampicin against Staphylococcus aureus. J Antimicrob Chemother. 63:485–488. 2009.PubMed/NCBI View Article : Google Scholar

Cho OH, Bae IG, Moon SM, Park SY, Kwak YG, Kim BN, Yu SN, Jeon MH, Kim T, Choo EJ, et al: Therapeutic outcome of spinal implant infections caused by Staphylococcus aureus: A retrospective observational study. Medicine (Baltimore). 97(e12629)2018.PubMed/NCBI View Article : Google Scholar

Herrmann G, Yang L, Wu H, Song Z, Wang H, Høiby N, Ulrich M, Molin S, Riethmüller J and Döring G: Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa. J Infect Dis. 202:1585–1592. 2010.PubMed/NCBI View Article : Google Scholar

Giamarellou H, Zissis NP, Tagari G and Bouzos J: In vitro synergistic activities of aminoglycosides and new beta-lactams against multiresistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 25:534–536. 1984.PubMed/NCBI View Article : Google Scholar

Giamarellou H: Aminoglycosides plus beta-lactams against gram-negative organisms. Evaluation of in vitro synergy and chemical interactions. Am J Med. 80:126–137. 1986.PubMed/NCBI View Article : Google Scholar

Olson ME, Slater SR, Rupp ME and Fey PD: Rifampicin enhances activity of daptomycin and vancomycin against both a polysaccharide intercellular adhesin (PIA)-dependent and -independent Staphylococcus epidermidis biofilm. J Antimicrob Chemother. 65:2164–2171. 2010.PubMed/NCBI View Article : Google Scholar

Zimmerli W and Sendi P: Role of rifampin against staphylococcal biofilm infections in vitro, in animal models, and in orthopedic-device-related infections. Antimicrob Agents Chemother. 63:e01746–18. 2019.PubMed/NCBI View Article : Google Scholar

Niska JA, Shahbazian JH, Ramos RI, Francis KP, Bernthal NM and Miller LS: Vancomycin-rifampin combination therapy has enhanced efficacy against an experimental Staphylococcus aureus prosthetic joint infection. Antimicrob Agents Chemother. 57:5080–5086. 2013.PubMed/NCBI View Article : Google Scholar

Ferreira Chacon JM, Hato de Almeida E, de Lourdes Simões R, Lazzarin C, Ozório V, Alves BC, Mello de Andréa ML, Santiago Biernat M and Biernat JC: Randomized study of minocycline and edetic acid as a locking solution for central line (port-a-cath) in children with cancer. Chemotherapy. 57:285–291. 2011.PubMed/NCBI View Article : Google Scholar

Vermeulen H, van Hattem JM, Storm-Versloot MN and Ubbink DT: Topical silver for treating infected wounds. Cochrane Database Syst Rev: CD005486, 2007.

Jiang Y, Zhang Q, Wang H, Välimäki M, Zhou Q, Dai W and Guo J: Effectiveness of silver and iodine dressings on wound healing: A systematic review and meta-analysis. BMJ Open. 14(e077902)2024.PubMed/NCBI View Article : Google Scholar

Tateda K, Comte R, Pechere JC, Köhler T, Yamaguchi K and Van Delden C: Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 45:1930–1933. 2001.PubMed/NCBI View Article : Google Scholar

Hoffmann N, Lee B, Hentzer M, Rasmussen TB, Song Z, Johansen HK, Givskov M and Høiby N: Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice. Antimicrob Agents Chemother. 51:3677–3687. 2007.PubMed/NCBI View Article : Google Scholar

Gupta S, Aruna C, Nagaraj S, Dias M and Muralidharan S: In vitro activity of tigecycline against multidrug-resistant gram-negative blood culture isolates from critically ill patients. J Antimicrob Chemother. 67:1293–1295. 2012.PubMed/NCBI View Article : Google Scholar

Kostoulias X, Fu Y, Morris FC, Yu C, Qu Y, Chang CC, Blakeway L, Landersdorfer CB, Abbott IJ, Wang L, et al: Ceftolozane/tazobactam disrupts Pseudomonas aeruginosa biofilms under static and dynamic conditions. J Antimicrob Chemother. 80:372–380. 2025.PubMed/NCBI View Article : Google Scholar

Miller MB and Bassler BL: Quorum sensing in bacteria. Annu Rev Microbiol. 55:165–199. 2001.PubMed/NCBI View Article : Google Scholar

Köhler T, Perron GG, Buckling A and van Delden C: Quorum sensing inhibition selects for virulence and cooperation in Pseudomonas aeruginosa. PLOS Pathog. 6(e1000883)2010.PubMed/NCBI View Article : Google Scholar

Tsikopoulos A, Petinaki E, Festas C, Tsikopoulos K, Meroni G, Drago L and Skoulakis C: In vitro inhibition of biofilm formation on silicon rubber voice prosthesis: Α systematic review and meta-analysis. ORL J Otorhinolaryngol Relat Spec. 84:10–29. 2022.PubMed/NCBI View Article : Google Scholar

Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, Skindersoe M, Larsen TO, Høiby N, Bjarnsholt T and Givskov M: Food as a source for quorum sensing inhibitors: Iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 78:2410–2421. 2012.PubMed/NCBI View Article : Google Scholar

Luo J, Dong B, Wang K, Cai S, Liu T, Cheng X, Lei D and Chen Y, Li Y, Kong J and Chen Y: Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. PLoS One. 12(e0176883)2017.PubMed/NCBI View Article : Google Scholar

Prince AA, Steiger JD, Khalid AN, Dogrhamji L, Reger C, Eau Claire SE, Chiu AG, Kennedy DW, Palmer JN and Cohen NA: Prevalence of biofilm-forming bacteria in chronic rhinosinusitis. Am J Rhinol. 22:239–245. 2008.PubMed/NCBI View Article : Google Scholar

Foreman A, Holtappels G, Psaltis AJ, Jervis-Bardy J, Field J, Wormald PJ and Bachert C: Adaptive immune responses in Staphylococcus aureus biofilm-associated chronic rhinosinusitis. Allergy. 66:1449–1456. 2011.PubMed/NCBI View Article : Google Scholar

Yadav MK, Vidal JE, Go YY, Kim SH, Chae SW and Song JJ: The LuxS/AI-2 quorum-sensing system of Streptococcus pneumoniae is required to cause disease, and to regulate virulence- and metabolism-related genes in a rat model of middle ear infection. Front Cell Infect Microbiol. 8(138)2018.PubMed/NCBI View Article : Google Scholar

Dawit G, Mequanent S and Makonnen E: Efficacy and safety of azithromycin and amoxicillin/clavulanate for otitis media in children: A systematic review and meta-analysis of randomized controlled trials. Ann Clin Microbiol Antimicrob. 20(28)2021.PubMed/NCBI View Article : Google Scholar

Brown HL, Hanman K, Reuter M, Betts RP and Van Vliet AHM: Campylobacter jejuni biofilms contain extracellular DNA and are sensitive to DNase I treatment. Front Microbiol. 6(699)2015.PubMed/NCBI View Article : Google Scholar

Tetz GV, Artemenko NK and Tetz VV: Effect of DNase and antibiotics on biofilm characteristics. Antimicrob Agents Chemother. 53:1204–1209. 2009.PubMed/NCBI View Article : Google Scholar

Gawande PV, Leung KP and Madhyastha S: Antibiofilm and antimicrobial efficacy of DispersinB^®-KSL-W peptide-based wound gel against chronic wound infection associated bacteria. Curr Microbiol. 68:635–641. 2014.PubMed/NCBI View Article : Google Scholar

Lamppa JW and Griswold KE: Alginate lyase exhibits catalysis-independent biofilm dispersion and antibiotic synergy. Antimicrob Agents Chemother. 57:137–145. 2013.PubMed/NCBI View Article : Google Scholar

Daboor SM, Rohde JR and Cheng Z: Disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate lyase enhances pathogen eradication by antibiotics. J Cyst Fibros. 20:264–270. 2021.PubMed/NCBI View Article : Google Scholar

Barraud N, Hassett DJ, Hwang SH, Rice SA, Kjelleberg S and Webb JS: Involvement of nitric oxide in biofilm dispersal of Pseudomonas aeruginosa. J Bacteriol. 188:7344–7353. 2006.PubMed/NCBI View Article : Google Scholar

Reffuveille F, de la Fuente-Núñez C, Mansour S and Hancock REW: A broad-spectrum antibiofilm peptide enhances Antibiotic Action against bacterial biofilms. Antimicrob Agents Chemother. 58:5363–5371. 2014.PubMed/NCBI View Article : Google Scholar

Le CF, Fang CM and Sekaran SD: Intracellular targeting mechanisms by antimicrobial peptides. Antimicrob Agents Chemother. 61:e02340–16. 2017.PubMed/NCBI View Article : Google Scholar

Kang J, Dietz MJ and Li B: Antimicrobial peptide LL-37 is bactericidal against Staphylococcus aureus biofilms. PLoS One. 14(e0216676)2019.PubMed/NCBI View Article : Google Scholar

Jalilsood T, Baradaran A, Song AAL, Foo HL, Mustafa S, Saad WZ, Yusoff K and Rahim RA: Inhibition of pathogenic and spoilage bacteria by a novel biofilm-forming Lactobacillus isolate: A potential host for the expression of heterologous proteins. Microb Cell Fact. 14(96)2015.PubMed/NCBI View Article : Google Scholar

Li J, Zhang Q, Zhao J, Zhang H and Chen W: Lactobacillus-derived components for inhibiting biofilm formation in the food industry. World J Microbiol Biotechnol. 40(117)2024.PubMed/NCBI View Article : Google Scholar

Algburi AR, Jassim SM, Popov IV, Weeks R and Chikindas ML: Lactobacillus acidophilus VB1 co-aggregates and inhibits biofilm formation of chronic otitis media-associated pathogens. Braz J Microbiol. 55:2581–2592. 2024.PubMed/NCBI View Article : Google Scholar

Wongchai M, Wongkaewkhiaw S, Kanthawong S, Roytrakul S and Aunpad R: Dual-function antimicrobial-antibiofilm peptide hybrid to tackle biofilm-forming Staphylococcus epidermidis. Ann Clin Microbiol Antimicrob. 23(44)2024.PubMed/NCBI View Article : Google Scholar

Tintino SR, Souza VCAD, Silva JMAD, Oliveira-Tintino CDDM, Pereira PS, Leal-Balbino TC, Pereira-Neves A, Siqueira-Junior JP, da Costa JGM, Rodrigues FFG, et al: Effect of vitamin K₃ inhibiting the function of NorA efflux pump and its gene expression on Staphylococcus aureus. Membranes (Basel). 10(130)2020.PubMed/NCBI View Article : Google Scholar

Monteiro KLC, de Aquino TM and Mendonça Junior FJB: An update on Staphylococcus aureus NorA efflux pump inhibitors. Curr Top Med Chem. 20:2168–2185. 2020.PubMed/NCBI View Article : Google Scholar

Lu X, Wang G, Xie Y, Tang W, Liu B and Zhang J: Efflux pump inhibitor combined with ofloxacin decreases MRSA biofilm formation by regulating the gene expression of NorA and quorum sensing. RSC Adv. 13:2707–2717. 2023.PubMed/NCBI View Article : Google Scholar

Govindarajan DK, Meghanathan Y, Sivaramakrishnan M, Kothandan R, Muthusamy A, Seviour TW and Kandaswamy K: Enterococcus faecalis thrives in dual-species biofilm models under iron-rich conditions. Arch Microbiol. 204(710)2022.PubMed/NCBI View Article : Google Scholar

Brunson DN, Colomer-Winter C, Lam LN and Lemos JA: Identification of multiple iron uptake mechanisms in Enterococcus faecalis and their relationship to virulence. Infect Immun. 91(e0049622)2023.PubMed/NCBI View Article : Google Scholar

Kaneko Y, Thoendel M, Olakanmi O, Britigan BE and Singh PK: The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity. J Clin Invest. 117:877–888. 2007.PubMed/NCBI View Article : Google Scholar

Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, et al: Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections. Sci Transl Med. 10(eaat7520)2018.PubMed/NCBI View Article : Google Scholar

Nobile CJ, Ennis CL, Hartooni N, Johnson AD and Lohse MB: A selective serotonin reuptake inhibitor, a proton pump inhibitor, and two calcium channel blockers inhibit Candida albicans biofilms. Microorganisms. 8(756)2020.PubMed/NCBI View Article : Google Scholar

Yu Q, Ding X, Xu N, Cheng X, Qian K, Zhang B, Xing L and Li M: In vitro activity of verapamil alone and in combination with fluconazole or tunicamycin against Candida albicans biofilms. Int J Antimicrob Agents. 41:179–182. 2013.PubMed/NCBI View Article : Google Scholar

Koushki K, Shahbaz SK, Mashayekhi K, Sadeghi M, Zayeri ZD, Taba MY, Banach M, Al-Rasadi K, Johnston TP and Sahebkar A: Anti-inflammatory action of statins in cardiovascular disease: The role of inflammasome and toll-like receptor pathways. Clin Rev Allergy Immunol. 60:175–199. 2021.PubMed/NCBI View Article : Google Scholar

Kong F, Ye B, Lin L, Cai X, Huang W and Huang Z: Atorvastatin suppresses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB signaling in PMA-stimulated THP-1 monocytes. Biomed Pharmacother. 82:167–172. 2016.PubMed/NCBI View Article : Google Scholar

Graziano TS, Cuzzullin MC, Franco GC, Schwartz-Filho HO, de Andrade ED, Groppo FC and Cogo-Müller K: Statins and antimicrobial effects: Simvastatin as a potential drug against Staphylococcus aureus biofilm. PLoS One. 10(e0128098)2015.PubMed/NCBI View Article : Google Scholar

Khodaparast S, Ghanbari F and Zamani H: Evaluation of the effect of ibuprofen in combination with ciprofloxacin on the virulence-associated traits, and efflux pump genes of Pseudomonas aeruginosa. World J Microbiol Biotechnol. 38(125)2022.PubMed/NCBI View Article : Google Scholar

Abbas HA, Atallah H, El-Sayed MA and El-Ganiny AM: Diclofenac mitigates virulence of multidrug-resistant Staphylococcus aureus. Arch Microbiol. 202:2751–2760. 2020.PubMed/NCBI View Article : Google Scholar

Severino P, Silveira EF, Loureiro K, Chaud MV, Antonini D, Lancellotti M, Sarmento VH, da Silva CF, Santana MHA and Souto EB: Antimicrobial activity of polymyxin-loaded solid lipid nanoparticles (PLX-SLN): Characterization of physicochemical properties and in vitro efficacy. Eur J Pharm Sci. 106:177–184. 2017.PubMed/NCBI View Article : Google Scholar

Wang XF, Zhang SL, Zhu LY, Xie SY, Dong Z, Wang Y and Zhou WZ: Enhancement of antibacterial activity of tilmicosin against Staphylococcus aureus by solid lipid nanoparticles in vitro and in vivo. Vet J. 191:115–120. 2012.PubMed/NCBI View Article : Google Scholar

Kotrange H, Najda A, Bains A, Gruszecki R, Chawla P and Tosif MM: Metal and metal oxide nanoparticle as a novel antibiotic carrier for the direct delivery of antibiotics. Int J Mol Sci. 22(9596)2021.PubMed/NCBI View Article : Google Scholar

Patro SK, Panda NK and Sharma M: Drug repurposing for, ENT and head and neck, infectious and oncologic diseases: Current practices and future possibilities. In: Sobti RC, Lal SK and Goyal RK (eds). Drug Repurposing for Emerging Infectious Diseases and Cancer. Singapore: Springer Nature, pp253-282, 2023.

Kora AJ and Arunachalam J: Assessment of antibacterial activity of silver nanoparticles on Pseudomonas aeruginosa and its mechanism of action. World J Microbiol Biotechnol. 27:1209–1216. 2011.

Caciandone M, Niculescu AG, Grumezescu V, Bîrcă AC, Ghica IC, Vasile BȘ, Oprea O, Nica IC, Stan MS, Holban AM, et al: Magnetite nanoparticles functionalized with therapeutic agents for enhanced ENT antimicrobial properties. Antibiotics (Basel). 11(623)2022.PubMed/NCBI View Article : Google Scholar

García-Alvarez R, Izquierdo-Barba I and Vallet-Regí M: 3D scaffold with effective multidrug sequential release against bacteria biofilm. Acta Biomater. 49:113–126. 2017.PubMed/NCBI View Article : Google Scholar

Lee M, Park CG, Huh BK, Kim SN, Lee SH, Khalmuratova R, Park JW, Shin HW and Choy YB: Sinonasal delivery of resveratrol via mucoadhesive nanostructured microparticles in a nasal polyp mouse model. Sci Rep. 7(40249)2017.PubMed/NCBI View Article : Google Scholar

Cano EJ, Caflisch KM, Bollyky PL, Van Belleghem JD, Patel R, Fackler J, Brownstein MJ, Horne B, Biswas B, Henry M, et al: Phage therapy for limb-threatening prosthetic knee Klebsiella pneumoniae infection: Case report and in vitro characterization of anti-biofilm activity. Clin Infect Dis. 73:e144–e151. 2021.PubMed/NCBI View Article : Google Scholar

Manoharadas S, Altaf M, Alrefaei AF, Hussain SA, Devasia RM, Badjah Hadj AYM and Abuhasil MSA: Microscopic analysis of the inhibition of staphylococcal biofilm formation by Escherichia coli and the disruption of preformed staphylococcal biofilm by bacteriophage. Microsc Res Tech. 84:1513–1521. 2021.PubMed/NCBI View Article : Google Scholar

Morris J, Kelly N, Elliott L, Grant A, Wilkinson M, Hazratwala K and McEwen P: Evaluation of bacteriophage anti-biofilm activity for potential control of orthopedic implant-related infections caused by Staphylococcus aureus. Surg Infect (Larchmt). 20:16–24. 2019.PubMed/NCBI View Article : Google Scholar

Zhao M, Li H, Gan D, Wang M, Deng H and Yang QE: Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic Klebsiella pneumoniae. mSystems. 9(e0060724)2024.PubMed/NCBI View Article : Google Scholar

Fong SA, Drilling A, Morales S, Cornet ME, Woodworth BA, Fokkens WJ, Psaltis AJ, Vreugde S and Wormald PJ: Activity of bacteriophages in removing biofilms of Pseudomonas aeruginosa isolates from chronic rhinosinusitis patients. Front Cell Infect Microbiol. 7(418)2017.PubMed/NCBI View Article : Google Scholar

Gordon M and Ramirez P: Efficacy and experience of bacteriophages in biofilm-related infections. Antibiotics (Basel). 13(125)2024.PubMed/NCBI View Article : Google Scholar

Lim DJ, Skinner D, Mclemore J, Rivers N, Elder JB, Allen M, Koch C, West J, Zhang S, Thompson HM, et al: In-vitro evaluation of a ciprofloxacin and azithromycin sinus stent for Pseudomonas aeruginosa biofilms. Int Forum Allergy Rhinol. 10:121–127. 2020.PubMed/NCBI View Article : Google Scholar

Pakkulnan R, Thonglao N and Chareonsudjai S: DNase I and chitosan enhance efficacy of ceftazidime to eradicate Burkholderia pseudomallei biofilm cells. Sci Rep. 13(1059)2023.PubMed/NCBI View Article : Google Scholar

Cresti L, Falciani C, Cappello G, Brunetti J, Vailati S, Melloni E, Bracci L and Pini A: Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs. Sci Rep. 12(19294)2022.PubMed/NCBI View Article : Google Scholar