Phase I clinical study of a personalized peptide vaccination available for six different human leukocyte antigen (HLA-A2, -A3, -A11, -A24, -A31 and -A33)-positive patients with advanced cancer

  • Authors:
    • Akira Yamada
    • Masanori Noguchi
    • Nobukazu Komatsu
    • Shigetaka  Suekane
    • Shigeru  Yutani
    • Fukuko Moriya
    • Takashi Mine
    • Kosuke  Momozono
    • Koichiro Kawano
    • Kyogo Itoh
  • View Affiliations

  • Published online on: December 2, 2010     https://doi.org/10.3892/etm.2010.177
  • Pages: 109-117
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Abstract

The majority of peptide-based cancer vaccines under development are for human leukocyte antigen (HLA)-A2- or -A24-positive patients. To overcome this limitation, we conducted a phase I clinical study of peptide vaccines designed for cancer patients with six different HLA-A types. Eligible patients were required to have failed prior standard cancer therapies and to be positive for the HLA-A2, -A24 or -A3 (A3, A11, A31 and A33) supertype. Three sets of 8 candidate peptides (24 peptides in total) were provided for vaccination to HLA-A2+, HLA-A24+ and HLA-A3+ patients, respectively. Personalization of the vaccination peptides from the candidate pool was made by considering the patients' HLA types and pre-existing levels of IgGs to the candidate peptides. Seventeen patients were enrolled in this study. The peptide vaccinations were well tolerated in all patients with no vaccine-related severe adverse events. Augmentation of cytotoxic T lymphocyte (CTL) or IgG responses specific to the vaccinated peptides was observed in 11 or 10 out of 13 cases tested, respectively. This new type of vaccine is recommended for phase II clinical trial because of its tolerability and the immune responses to the vaccinated peptides.
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January-February 2011
Volume 2 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yamada A, Noguchi M, Komatsu N, Suekane S, Yutani S, Moriya F, Mine T, Momozono K, Kawano K, Itoh K, Itoh K, et al: Phase I clinical study of a personalized peptide vaccination available for six different human leukocyte antigen (HLA-A2, -A3, -A11, -A24, -A31 and -A33)-positive patients with advanced cancer. Exp Ther Med 2: 109-117, 2011
APA
Yamada, A., Noguchi, M., Komatsu, N., Suekane, S., Yutani, S., Moriya, F. ... Itoh, K. (2011). Phase I clinical study of a personalized peptide vaccination available for six different human leukocyte antigen (HLA-A2, -A3, -A11, -A24, -A31 and -A33)-positive patients with advanced cancer. Experimental and Therapeutic Medicine, 2, 109-117. https://doi.org/10.3892/etm.2010.177
MLA
Yamada, A., Noguchi, M., Komatsu, N., Suekane, S., Yutani, S., Moriya, F., Mine, T., Momozono, K., Kawano, K., Itoh, K."Phase I clinical study of a personalized peptide vaccination available for six different human leukocyte antigen (HLA-A2, -A3, -A11, -A24, -A31 and -A33)-positive patients with advanced cancer". Experimental and Therapeutic Medicine 2.1 (2011): 109-117.
Chicago
Yamada, A., Noguchi, M., Komatsu, N., Suekane, S., Yutani, S., Moriya, F., Mine, T., Momozono, K., Kawano, K., Itoh, K."Phase I clinical study of a personalized peptide vaccination available for six different human leukocyte antigen (HLA-A2, -A3, -A11, -A24, -A31 and -A33)-positive patients with advanced cancer". Experimental and Therapeutic Medicine 2, no. 1 (2011): 109-117. https://doi.org/10.3892/etm.2010.177