Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-April 2011 Volume 2 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-April 2011 Volume 2 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy

  • Authors:
    • Jin-Soon Suh
    • Won-Ho Hahn
    • Jong Seok Lee
    • Hae Jeong Park
    • Mi-Ja Kim
    • Sung Wook Kang
    • Joo-Ho Chung
    • Byoung-Soo Cho
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, East West Kidney Disease Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea, Department of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul 130-701, Korea, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Korea
  • Pages: 337-341
    |
    Published online on: January 18, 2011
       https://doi.org/10.3892/etm.2011.195
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:


Abstract

Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor β (TGFB) superfamily and are important in both preservation of kidney function and resistance to injury. BMP2 is highly regulated in the kidney, and high affinity binding sites for BMP2 have been identified in kidney epithelial cells. BMP2 has been demonstrated to play various roles in the pathogenesis of renal diseases. However, the role of the BMP2 gene in glomerulonephritis has not been previously investigated. We aimed to evaluate the association of BMP2 gene polymorphisms with immunoglobulin A nephropathy (IgAN) in children. We evaluated 187 pediatric patients with biopsy-confimed IgAN and 262 healthy controls. Two coding single nucleotide polymorphisms (cSNPs) in the BMP2 gene [rs235768 (missense, Arg190Ser) and rs1049007 (synonymous, Ser87Ser)] were selected and genotyped by direct sequencing. Genotypes of rs1049007 were associated with childhood IgAN in the codominant model II (GG vs. AA) [p=0.02; OR (95% CI), 0.16 (0.04-0.70)] and in the recessive model [p=0.0023; OR (95% CI), 0.16 (0.04-0.69)]. We also found an association between rs235768 and IgAN in the codominant model II (TT vs. AA) [p=0.01; OR (95% CI), 0.08 (0.01-0.57)] and in the recessive model [p=0.0002; OR (95% CI), 0.07 (0.01-0.55)]. After Bonferroni correction, these associations of rs235768 and rs1049007 with IgAN risk remained significant. In the haplotype analysis, the TG haplotype [p=0.01; OR (95% CI), 6.76 (1.55-29.50) in the dominant model] and AA haplotype [p=0.01; OR (95% CI), 0.08 (0.01-0.59) in the recessive model] showed associations with IgAN. The BMP2 gene may contribute to susceptibility to IgAN in Korean children.
View Figures

Figure 1

View References

1. 

Barratt J and Feehally J: IgA nephropathy. J Am Soc Nephrol. 16:2088–2097. 2005. View Article : Google Scholar : PubMed/NCBI

2. 

Barratt J, Smith AC, Molyneux K and Feehally J: Immunopathogenesis of IgAN. Semin Immunopathol. 29:427–443. 2007. View Article : Google Scholar

3. 

Chen D, Zhao M and Mundy GR: Bone morphogenetic proteins. Growth Factors. 22:233–241. 2004. View Article : Google Scholar

4. 

Maciel TT, Kempf H and Campos AH: Targeting bone morphogenetic protein signaling on renal and vascular diseases. Curr Opin Nephrol Hypertens. 19:26–31. 2010. View Article : Google Scholar : PubMed/NCBI

5. 

Simic P and Vukicevic S: Bone morphogenetic proteins in development and homeostasis of kidney. Cytokine Growth Factor Rev. 16:299–308. 2005. View Article : Google Scholar : PubMed/NCBI

6. 

Yang YL, Liu YS, Chuang LY, et al: Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors. Endocrinology. 150:727–740. 2009. View Article : Google Scholar : PubMed/NCBI

7. 

Iwasaki S, Tsuruoka N, Hattori A, Sato M, Tsujimoto M and Kohno M: Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2. J Biol Chem. 270:5476–5482. 1995. View Article : Google Scholar : PubMed/NCBI

8. 

Ghosh Choudhury G, Kim YS, Simon M, et al: Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase. J Biol Chem. 274:10897–10902. 1999.

9. 

Ghosh Choudhury G, Jin DC, Kim Y, Celeste A, Ghosh-Choudhury N and Abboud HE: Bone morphogenetic protein-2 inhibits MAPK-dependent Elk-1 transactivation and DNA synthesis induced by EGF in mesangial cells. Biochem Biophys Res Commun. 258:490–496. 1999.PubMed/NCBI

10. 

Pache G, Schafer C, Wiesemann S, et al: Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes. Am J Physiol Renal Physiol. 291:F654–F662. 2006. View Article : Google Scholar : PubMed/NCBI

11. 

Chan WL, Leung JC, Chan LY, Tam KY, Tang SC and Lai KN: BMP-7 protects mesangial cells from injury by polymeric IgA. Kidney Int. 74:1026–1039. 2008. View Article : Google Scholar : PubMed/NCBI

12. 

Sole X, Guino E, Valls J, Iniesta R and Moreno V: SNPStats: a web tool for the analysis of association studies. Bioinformatics. 22:1928–1929. 2006. View Article : Google Scholar : PubMed/NCBI

13. 

Gabriel SB, Schaffner SF, Nguyen H, et al: The structure of haplotype blocks in the human genome. Science. 296:2225–2229. 2002. View Article : Google Scholar : PubMed/NCBI

14. 

Nguyen TQ, Roestenberg P, van Nieuwenhoven FA, et al: CTGF inhibits BMP-7 signaling in diabetic nephropathy. J Am Soc Nephrol. 19:2098–2107. 2008. View Article : Google Scholar : PubMed/NCBI

15. 

Park Y, Kim JW, Kim DS, et al: The bone morphogenesis protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer. Cancer Res Treat. 40:127–132. 2008. View Article : Google Scholar : PubMed/NCBI

16. 

Ara J, See J, Mamontov P, et al: Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis. J Neurosci Res. 86:125–135. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Weiskirchen R, Meurer SK, Gressner OA, Herrmann J, Borkham-Kamphorst E and Gressner AM: BMP-7 as antagonist of organ fibrosis. Front Biosci. 14:4992–5012. 2009. View Article : Google Scholar : PubMed/NCBI

18. 

Rosen V: BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev. 20:475–480. 2009. View Article : Google Scholar : PubMed/NCBI

19. 

Langenfeld EM, Calvano SE, Abou-Nukta F, Lowry SF, Amenta P and Langenfeld J: The mature bone morphogenetic protein-2 is aberrantly expressed in non-small cell lung carcinomas and stimulates tumor growth of A549 cells. Carcinogenesis. 24:1445–1454. 2003. View Article : Google Scholar : PubMed/NCBI

20. 

Kleeff J, Maruyama H, Ishiwata T, et al: Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo. Gastroenterology. 116:1202–1216. 1999. View Article : Google Scholar : PubMed/NCBI

21. 

Liu C, Tian G, Tu Y, Fu J, Lan C and Wu N: Expression pattern and clinical prognostic relevance of bone morphogenetic protein-2 in human gliomas. Jpn J Clin Oncol. 39:625–631. 2009. View Article : Google Scholar : PubMed/NCBI

22. 

Baelde HJ, Eikmans M, Doran PP, Lappin DW, de Heer E and Bruijn JA: Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy. Am J Kidney Dis. 43:636–650. 2004. View Article : Google Scholar : PubMed/NCBI

23. 

Dalfino G, Simone S, Porreca S, et al: Bone morphogenetic protein-2 may represent the molecular link between oxidative stress and vascular stiffness in chronic kidney disease. Atherosclerosis. 211:418–423. 2010. View Article : Google Scholar : PubMed/NCBI

24. 

Sieber C, Kopf J, Hiepen C and Knaus P: Recent advances in BMP receptor signaling. Cytokine Growth Factor Rev. 20:343–355. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Suh J, Hahn W, Lee JS, Park HJ, Kim M, Kang SW, Chung J and Cho B: Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy. Exp Ther Med 2: 337-341, 2011.
APA
Suh, J., Hahn, W., Lee, J.S., Park, H.J., Kim, M., Kang, S.W. ... Cho, B. (2011). Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy. Experimental and Therapeutic Medicine, 2, 337-341. https://doi.org/10.3892/etm.2011.195
MLA
Suh, J., Hahn, W., Lee, J. S., Park, H. J., Kim, M., Kang, S. W., Chung, J., Cho, B."Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy". Experimental and Therapeutic Medicine 2.2 (2011): 337-341.
Chicago
Suh, J., Hahn, W., Lee, J. S., Park, H. J., Kim, M., Kang, S. W., Chung, J., Cho, B."Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy". Experimental and Therapeutic Medicine 2, no. 2 (2011): 337-341. https://doi.org/10.3892/etm.2011.195
Copy and paste a formatted citation
x
Spandidos Publications style
Suh J, Hahn W, Lee JS, Park HJ, Kim M, Kang SW, Chung J and Cho B: Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy. Exp Ther Med 2: 337-341, 2011.
APA
Suh, J., Hahn, W., Lee, J.S., Park, H.J., Kim, M., Kang, S.W. ... Cho, B. (2011). Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy. Experimental and Therapeutic Medicine, 2, 337-341. https://doi.org/10.3892/etm.2011.195
MLA
Suh, J., Hahn, W., Lee, J. S., Park, H. J., Kim, M., Kang, S. W., Chung, J., Cho, B."Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy". Experimental and Therapeutic Medicine 2.2 (2011): 337-341.
Chicago
Suh, J., Hahn, W., Lee, J. S., Park, H. J., Kim, M., Kang, S. W., Chung, J., Cho, B."Coding polymorphisms of bone morphogenetic protein 2 contribute to the development of childhood IgA nephropathy". Experimental and Therapeutic Medicine 2, no. 2 (2011): 337-341. https://doi.org/10.3892/etm.2011.195
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team