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March-April 2011 Volume 2 Issue 2

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Article

High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma

  • Authors:
    • J. Brunotte
    • H. C. Bock
    • W. Brück
    • B. Hemmerlein
    • H. Strik
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, University Medicine Göttingen, Göttingen, Germany, Department of Neurosurgery, University Medicine Göttingen, Göttingen, Germany, Department of Neuropathology, University Medicine Göttingen, Göttingen, Germany, Department of Pathology, University Medicine Göttingen, Göttingen, Germany, Department of Neurology, University of Marburg, D-35039 Marburg, Germany
  • Pages: 295-299
    |
    Published online on: January 19, 2011
       https://doi.org/10.3892/etm.2011.198
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Abstract

Erythropoietin (EPO) is used to treat anemia in neoplastic disease. EPO also exerts neuroprotective effects on neuronal cells, making a prophylactic use against the neurocognitive effects of radiochemotherapy probable. However, EPO/EPO-receptor (EPOR) signalling has been also detected in glioblastoma cells. Data collected in vitro and in vivo show conflicting results on the effect of EPO on malignant gliomas. The association between EPO and EPOR expression and the prognosis of human glioblastomas was analyzed. Probes of human glioblastomas with complete documentation of clinical course and treatment were assessed by immunohistochemistry for the expression of EPO and EPOR (n=80). Using univariate and multivariate survival analysis, the association with age, gender, radiation, chemotherapy and extent of resection was determined. High levels of EPOR were correlated with a median survival advantage of 7 months (p<0.01). By univariate, but not multivariate, analysis, high levels of EPO and EPOR were associated with a significant prolongation of 7 months median survival when compared to low levels of both molecules. In patients treated with radiochemotherapy adjuvant to surgery, the median survival was 6.5 months longer in patients with high levels of EPOR (p<0.04). According to previous studies, longer patient survival is associated with EPOR expression. Therefore, EPO appears to be safe for the treatment of anemia in glioblastoma patients. Ηowever, a prophylactic use, i.e., for neuroprotection, is not recommended in light of the functional studies described in the literature.
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Copy and paste a formatted citation
Spandidos Publications style
Brunotte J, Bock HC, Brück W, Hemmerlein B and Strik H: High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma. Exp Ther Med 2: 295-299, 2011.
APA
Brunotte, J., Bock, H.C., Brück, W., Hemmerlein, B., & Strik, H. (2011). High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma. Experimental and Therapeutic Medicine, 2, 295-299. https://doi.org/10.3892/etm.2011.198
MLA
Brunotte, J., Bock, H. C., Brück, W., Hemmerlein, B., Strik, H."High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma". Experimental and Therapeutic Medicine 2.2 (2011): 295-299.
Chicago
Brunotte, J., Bock, H. C., Brück, W., Hemmerlein, B., Strik, H."High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma". Experimental and Therapeutic Medicine 2, no. 2 (2011): 295-299. https://doi.org/10.3892/etm.2011.198
Copy and paste a formatted citation
x
Spandidos Publications style
Brunotte J, Bock HC, Brück W, Hemmerlein B and Strik H: High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma. Exp Ther Med 2: 295-299, 2011.
APA
Brunotte, J., Bock, H.C., Brück, W., Hemmerlein, B., & Strik, H. (2011). High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma. Experimental and Therapeutic Medicine, 2, 295-299. https://doi.org/10.3892/etm.2011.198
MLA
Brunotte, J., Bock, H. C., Brück, W., Hemmerlein, B., Strik, H."High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma". Experimental and Therapeutic Medicine 2.2 (2011): 295-299.
Chicago
Brunotte, J., Bock, H. C., Brück, W., Hemmerlein, B., Strik, H."High expression levels of erythropoietin and its receptor are not correlated with shorter survival in human glioblastoma". Experimental and Therapeutic Medicine 2, no. 2 (2011): 295-299. https://doi.org/10.3892/etm.2011.198
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