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Article

Decreased type III collagen expression in human uterine cervix of prolapse uteri

  • Authors:
    • Masaaki Iwahashi
    • Yasuteru Muragaki
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641-0012, Japan, Department of Pathology, Wakayama Medical University, Wakayama 641-0012, Japan
  • Pages: 271-274
    |
    Published online on: January 20, 2011
       https://doi.org/10.3892/etm.2011.204
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Abstract

The precise mechanism of prolapse uteri is not fully understood. There is evidence to suggest that abnormalities of collagen, the main component of extracellular matrix, or its repair mechanism, may predispose women to prolapse. To investigate the characteristic structure of human uterine cervix of patients with prolapse uteri, various types of collagen expression in the uterine cervix tissues of the prolapse uteri were compared to those of normal uterine cervix. After informed consent, 36 specimens of uterine cervical tissues were obtained at the time of surgery from 16 postmenopausal women with prolapse uteri (stage III-IV by the Pelvic Organ Prolapse Quantification examination) and 20 postmenopausal women without prolapse uteri (control group). Collagens were extracted from the uterine cervix tissues by salt precipitation methods. The relative levels of various collagens were evaluated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The uterine cervix was longer in the patients with prolapse uteri than those of postmenopausal controls without prolapse uteri. The ratios of type III to type I collagen in the uterine cervical tissues were significantly decreased in the prolapse uteri, as compared to those of the postmenopausal uterine cervix without prolapse. These results suggest that decreased type III collagen expression may play an important role in determing the physiology and structure of the uterine cervix tissues of prolapse uteri.
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Copy and paste a formatted citation
Spandidos Publications style
Iwahashi M and Muragaki Y: Decreased type III collagen expression in human uterine cervix of prolapse uteri. Exp Ther Med 2: 271-274, 2011.
APA
Iwahashi, M., & Muragaki, Y. (2011). Decreased type III collagen expression in human uterine cervix of prolapse uteri. Experimental and Therapeutic Medicine, 2, 271-274. https://doi.org/10.3892/etm.2011.204
MLA
Iwahashi, M., Muragaki, Y."Decreased type III collagen expression in human uterine cervix of prolapse uteri". Experimental and Therapeutic Medicine 2.2 (2011): 271-274.
Chicago
Iwahashi, M., Muragaki, Y."Decreased type III collagen expression in human uterine cervix of prolapse uteri". Experimental and Therapeutic Medicine 2, no. 2 (2011): 271-274. https://doi.org/10.3892/etm.2011.204
Copy and paste a formatted citation
x
Spandidos Publications style
Iwahashi M and Muragaki Y: Decreased type III collagen expression in human uterine cervix of prolapse uteri. Exp Ther Med 2: 271-274, 2011.
APA
Iwahashi, M., & Muragaki, Y. (2011). Decreased type III collagen expression in human uterine cervix of prolapse uteri. Experimental and Therapeutic Medicine, 2, 271-274. https://doi.org/10.3892/etm.2011.204
MLA
Iwahashi, M., Muragaki, Y."Decreased type III collagen expression in human uterine cervix of prolapse uteri". Experimental and Therapeutic Medicine 2.2 (2011): 271-274.
Chicago
Iwahashi, M., Muragaki, Y."Decreased type III collagen expression in human uterine cervix of prolapse uteri". Experimental and Therapeutic Medicine 2, no. 2 (2011): 271-274. https://doi.org/10.3892/etm.2011.204
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