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Article

Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis

  • Authors:
    • Yu Sato
    • Kensuke Kumamoto
    • Katsuharu Saito
    • Hirokazu Okayama
    • Suguru Hayase
    • Yasuhide Kofunato
    • Koutaro Miyamoto
    • Izumi Nakamura
    • Shinji Ohki
    • Yoshihisa Koyama
    • Seiichi Takenoshita
  • View Affiliations / Copyright

    Affiliations: Department of Organ Regulatory Surgery, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan
  • Pages: 239-243
    |
    Published online on: January 20, 2011
       https://doi.org/10.3892/etm.2011.210
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Abstract

Annexin A1 (ANXA1) is a calcium-dependent phospholipid-linked protein, involved in anti-inflammatory effects, regulation of cellular differentiation, proliferation and apoptosis. In the present study, we investigated the expression of ANXA1 in gastric and colon cancer, and analyzed the relationship between ANXA1 expression and clinicopathological factors. ANXA1 mRNA expression in gastric and colon cancer tissues was not significantly changed compared to that in normal tissues. When ANXA1 protein expression was evaluated by immunohistochemical staining, ANXA1 expression was observed in 76 of 135 cases of gastric cancer (56.3%), and correlations were found between ANXA1 expression and depth of wall invasion (P<0.001), lymphatic invasion (P=0.023), venous invasion (P=0.002), lymph node metastasis (P=0.001) and UICC stage (P<0.001). Disease-specific survival rate was significantly lower in cases with ANXA1 expression compared to that in cases without (P=0.0053). In colon cancer, ANXA1 expression was detected in 61 of 210 cases (29.0%) and correlations were found with gender (P=0.038), lymphatic invasion (P=0.011), venous invasion (P=0.023), lymph node metastasis (P=0.042) and UICC stage (P=0.041). The disease-specific survival rate tended to be lower in cases with ANXA1 expression, although the differences were not statistically significant (P=0.6984). Our results indicate that up-regulated ANXA1 expression is involved in cancer invasion and lymph node metastasis. Furthermore, high levels of ANXA1 expression were implicated in poor prognosis of patients. ANXA1 may be applicable as a prognostic biomarker in gastric and colon cancer, and a potential target for treatment.
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1. 

Budhu A, Forgues M, Ye QH, et al: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell. 10:99–111. 2006. View Article : Google Scholar

2. 

Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, Yokota J, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW and Harris CC: Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst. 99:1257–1269. 2007. View Article : Google Scholar : PubMed/NCBI

3. 

Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM Jr and Jones NL: Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res. 69:632–639. 2009. View Article : Google Scholar

4. 

Muto T, Bussey HJ and Morson BC: The evolution of cancer of the colon and rectum. Cancer. 36:2251–2270. 1975. View Article : Google Scholar : PubMed/NCBI

5. 

Minamoto T, Sawaguchi K, Mai M, Yamashita N, Sugimura T and Esumi H: Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res. 54:2841–2844. 1994.PubMed/NCBI

6. 

Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L and Karin M: IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 15:103–113. 2009. View Article : Google Scholar : PubMed/NCBI

7. 

Lim LH and Pervaiz S: Annexin 1: the new face of an old molecule. FASEB J. 21:968–975. 2007. View Article : Google Scholar : PubMed/NCBI

8. 

Wang KL, Wu TT, Resetkova E, Wang H, Correa AM, Hofstetter WL, Swisher SG, Ajani JA, Rashid A, Hamilton SR and Albarracin CT: Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome. Clin Cancer Res. 12:4598–4604. 2006. View Article : Google Scholar : PubMed/NCBI

9. 

Bai XF, Ni XG, Zhao P, Liu SM, Wang HX, Guo B, Zhou LP, Liu F, Zhang JS, Wang K, Xie YQ, Shao YF and Zhao XH: Overexpression of annexin 1 in pancreatic cancer and its clinical significance. World J Gastroenterol. 10:1466–1470. 2004.PubMed/NCBI

10. 

Hummerich L, Müller R, Hess J, Kokocinski F, Hahn M, Fürstenberger G, Mauch C, Lichter P and Angel P: Identification of novel tumour-associated genes differentially expressed in the process of squamous cell cancer development. Oncogene. 25:111–121. 2006.PubMed/NCBI

11. 

Duncan R, Carpenter B, Main LC, Telfer C and Murray GI: Characterisation and protein expression profiling of annexins in colorectal cancer. Br J Cancer. 98:426–433. 2008. View Article : Google Scholar : PubMed/NCBI

12. 

Wang LD, Yang YH, Liu Y, Song HT, Zhang LY and Li PL: Decreased expression of annexin A1 during the progression of cervical neoplasia. J Int Med Res. 36:665–672. 2008. View Article : Google Scholar : PubMed/NCBI

13. 

Lin CY, Jeng YM, Chou HY, Hsu HC, Yuan RH, Chiang CP and Kuo MY: Nuclear localization of annexin A1 is a prognostic factor in oral squamous cell carcinoma. J Surg Oncol. 97:544–550. 2008. View Article : Google Scholar : PubMed/NCBI

14. 

Kang JS, Calvo BF, Maygarden SJ, Caskey LS, Mohler JL and Ornstein DK: Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Clin Cancer Res. 8:117–123. 2002.PubMed/NCBI

15. 

Chuthapisith S, Bean BE, Cowley G, Eremin JM, Samphao S, Layfield R, Kerr ID, Wiseman J, El-Sheemy M, Sreenivasan T and Eremin O: Annexins in human breast cancer: possible predictors of pathological response to neoadjuvant chemotherapy. Eur J Cancer. 45:1274–1281. 2009. View Article : Google Scholar : PubMed/NCBI

16. 

Cao Y, Li Y, Edelweiss M, Arun B, Rosen D, Resetkova E, Wu Y, Liu J, Sahin A and Albarracin CT: Loss of annexin A1 expression in breast cancer progression. Appl Immunohistochem Mol Morphol. 16:530–534. 2008. View Article : Google Scholar : PubMed/NCBI

17. 

Shen D, Nooraie F, Elshimali Y, Lonsberry V, He J, Bose S, Chia D, Seligson D, Chang HR and Goodglick L: Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis. Hum Pathol. 37:1583–1591. 2006. View Article : Google Scholar : PubMed/NCBI

18. 

lves VA, Nonogaki S, Cury PM, Wünsch-Filho V, de Carvalho MB, Michaluart-Júnior P, Moyses RA, Curioni OA, Figueiredo DL, Scapulatempo-Neto C, Parra ER, Polachini GM, Silistino-Souza R, Oliani SM, Silva-Júnior WA, Nobrega FG; Head and Neck Genome Project/GENCAPO; Tajara EH and Zago MA: Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. Histopathology. 53:715–727. 2008. View Article : Google Scholar : PubMed/NCBI

19. 

Kim SW, Rhee HJ, Ko J, Kim YJ, Kim HG, Yang JM, Choi EC and Na DS: Inhibition of cytosolic phospholipase A2 by annexin I. Specific interaction model and mapping of the interaction site. J Biol Chem. 276:15712–15719. 2001. View Article : Google Scholar : PubMed/NCBI

20. 

Gerke V and Moss SE: Annexins: from structure to function. Physiol Rev. 82:331–371. 2002.PubMed/NCBI

21. 

Parente L and Solito E: Annexin 1: more than an anti-phospholipase protein. Inflamm Res. 53:125–132. 2004. View Article : Google Scholar : PubMed/NCBI

22. 

Yu G, Wang J, Chen Y, Wang X, Pan J, Li Q and Xie K: Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer. Clin Exp Metastasis. 25:695–702. 2008. View Article : Google Scholar

23. 

Yi M and Schnitzer JE: Impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1-null mice. Proc Natl Acad Sci USA. 106:17886–17891. 2009. View Article : Google Scholar : PubMed/NCBI

24. 

Grewal T and Enrich C: Annexins – modulators of EGF receptor signalling and trafficking. Cell Signal. 21:847–858. 2009.

25. 

Babbin BA, Lee WY, Parkos CA, Winfree LM, Akyildiz A, Perretti M and Nusrat A: Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem. 281:19588–19599. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sato Y, Kumamoto K, Saito K, Okayama H, Hayase S, Kofunato Y, Miyamoto K, Nakamura I, Ohki S, Koyama Y, Koyama Y, et al: Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis. Exp Ther Med 2: 239-243, 2011.
APA
Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y. ... Takenoshita, S. (2011). Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis. Experimental and Therapeutic Medicine, 2, 239-243. https://doi.org/10.3892/etm.2011.210
MLA
Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Koyama, Y., Takenoshita, S."Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis". Experimental and Therapeutic Medicine 2.2 (2011): 239-243.
Chicago
Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Koyama, Y., Takenoshita, S."Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis". Experimental and Therapeutic Medicine 2, no. 2 (2011): 239-243. https://doi.org/10.3892/etm.2011.210
Copy and paste a formatted citation
x
Spandidos Publications style
Sato Y, Kumamoto K, Saito K, Okayama H, Hayase S, Kofunato Y, Miyamoto K, Nakamura I, Ohki S, Koyama Y, Koyama Y, et al: Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis. Exp Ther Med 2: 239-243, 2011.
APA
Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y. ... Takenoshita, S. (2011). Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis. Experimental and Therapeutic Medicine, 2, 239-243. https://doi.org/10.3892/etm.2011.210
MLA
Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Koyama, Y., Takenoshita, S."Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis". Experimental and Therapeutic Medicine 2.2 (2011): 239-243.
Chicago
Sato, Y., Kumamoto, K., Saito, K., Okayama, H., Hayase, S., Kofunato, Y., Miyamoto, K., Nakamura, I., Ohki, S., Koyama, Y., Takenoshita, S."Up-regulated Annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis". Experimental and Therapeutic Medicine 2, no. 2 (2011): 239-243. https://doi.org/10.3892/etm.2011.210
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