Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells

  • Authors:
    • Hitomi Yoshida
    • Naoko Okumura
    • Yuri Nishimura
    • Yasuko Kitagishi
    • Satoru Matsuda
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  • Published online on: April 1, 2011     https://doi.org/10.3892/etm.2011.246
  • Pages: 629-632
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Abstract

In the present study, we aimed to determine the effects of herbs or spices on the expression of presenilin 1, a molecule involved in γ-secretase activity and the generation of amyloid-β peptide in Alzheimer's disease. Western blot analysis revealed that presenilin 1 protein expression was down-regulated by stimulation with turmeric or cinnamon extracts in vitro, while the effects on presenilin 1 gene expression examined by reverse transcriptase-polymerase chain reaction were unaltered. Our results showed that curcumin, a component of turmeric, induced the down-regulation of presenilin 1 protein in Jurkat and K562 cell lines.
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July-August 2011
Volume 2 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yoshida H, Okumura N, Nishimura Y, Kitagishi Y and Matsuda S: Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells. Exp Ther Med 2: 629-632, 2011.
APA
Yoshida, H., Okumura, N., Nishimura, Y., Kitagishi, Y., & Matsuda, S. (2011). Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells. Experimental and Therapeutic Medicine, 2, 629-632. https://doi.org/10.3892/etm.2011.246
MLA
Yoshida, H., Okumura, N., Nishimura, Y., Kitagishi, Y., Matsuda, S."Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells". Experimental and Therapeutic Medicine 2.4 (2011): 629-632.
Chicago
Yoshida, H., Okumura, N., Nishimura, Y., Kitagishi, Y., Matsuda, S."Turmeric and curcumin suppress presenilin 1 protein expression in Jurkat cells". Experimental and Therapeutic Medicine 2, no. 4 (2011): 629-632. https://doi.org/10.3892/etm.2011.246