Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy

  • Authors:
    • Rie Osaki
    • Takashi Nishimura
    • Takayuki Takeuchi
    • Hirotsugu Imaeda
    • Yoshiaki Okumura
    • Makoto Shioya
    • Tamio Nakahara
    • Shigeki Bamba
    • Shinobu Nakajo
    • Yoshihide Fujiyama
    • Akira Andoh
  • View Affiliations

  • Published online on: April 7, 2011     https://doi.org/10.3892/etm.2011.250
  • Pages: 715-718
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Abstract

Prediction of the efficacy of pegylated interferon (PEG-IFN) plus ribavirin (RBV) therapy against hepatitis C (HCV) infection is valuable for determining its applications. This study investigated the relationship between the early response of HCV to PEG-IFN/RBV therapy and the interleukin (IL)-28B genetic polymorphism in patients with HCV infection. The genotypes of IL-28B rs8099917 T>G single nucleotide polymorphism were determined in 144 patients with HCV infection. Among them, 59 were treated with PEG-IFN/RBV. The frequency of IL-28B TT homozygosity was 75.2% in patients with HCV serotype 1 and 84.6% in patients with serotype 2. Multivariate analysis showed that IL-28B TT homozygosity (P=0.014) and the platelets number (P=0.030) was associated with the early suppression of HCV-RNA at 12 weeks after the start of PEG-IFN/RBV therapy. The IL-28B polymorphism was a significant pre-treatment predictor of the response to PEG-IFN/RBV therapy in patients with HCV infection.
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July-August 2011
Volume 2 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Osaki R, Nishimura T, Takeuchi T, Imaeda H, Okumura Y, Shioya M, Nakahara T, Bamba S, Nakajo S, Fujiyama Y, Fujiyama Y, et al: Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy. Exp Ther Med 2: 715-718, 2011.
APA
Osaki, R., Nishimura, T., Takeuchi, T., Imaeda, H., Okumura, Y., Shioya, M. ... Andoh, A. (2011). Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy. Experimental and Therapeutic Medicine, 2, 715-718. https://doi.org/10.3892/etm.2011.250
MLA
Osaki, R., Nishimura, T., Takeuchi, T., Imaeda, H., Okumura, Y., Shioya, M., Nakahara, T., Bamba, S., Nakajo, S., Fujiyama, Y., Andoh, A."Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy". Experimental and Therapeutic Medicine 2.4 (2011): 715-718.
Chicago
Osaki, R., Nishimura, T., Takeuchi, T., Imaeda, H., Okumura, Y., Shioya, M., Nakahara, T., Bamba, S., Nakajo, S., Fujiyama, Y., Andoh, A."Interleukin-28B polymorphisms are associated with an early viral response in patients receiving hepatitis C therapy". Experimental and Therapeutic Medicine 2, no. 4 (2011): 715-718. https://doi.org/10.3892/etm.2011.250