Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma

Fujita,Shigeki; Morii,Eiichi; Rahadiani,Nur; Wada,Naoki; Hori,Yumiko; Ikeda,Jun-Ichiro; Aozasa,Katsuyuki

doi:10.3892/etm.2011.269

Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma

Authors:
- Shigeki Fujita
- Eiichi Morii
- Nur Rahadiani
- Naoki Wada
- Yumiko Hori
- Jun-Ichiro Ikeda
- Katsuyuki Aozasa
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Affiliations: Department of Pathology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan
Published online on: May 12, 2011 https://doi.org/10.3892/etm.2011.269
Pages: 591-594

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Abstract

Aldehyde dehydrogenase (ALDH) 1 is expressed in various stem/progenitor cells, including cancer-initiating cells (CICs). In the present study, ALDH1 expression was immunohistochemically examined in diffuse large B-cell lymphoma (DLBCL). Unexpectedly, ALDH1 expression was occasionally detected in stromal cells, but not in lymphoma cells. Positively stained cells were CD68+ cells with voluminous cytoplasm and fascin+ cells with reticular morphology, designated as macrophages and dendritic cells (DCs), respectively. The presence of ALDH1+ macrophages was not correlated with stage, response to therapies and prognosis. However, cases with ALDH1+ DCs were mostly nodal, which showed a poorer response to therapies and a worse overall survival rate than cases without ALDH1+ DCs. The presence of ALDH1+ DCs appears to be involved in the malignant potential of DLBCL in lymph node.

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