Polymorphisms of IGFI contribute to the development of ischemic stroke
- Authors:
- Hak Jae Kim
- Su Kang Kim
- Hae Jeong Park
- Joo-Ho Chung
- Jinman Chun
- Dong Hwan Yun
- Young Ock Kim
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Affiliations: Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Chunan, Republic of Korea, Department of Pharmacology and Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Department of Physical Medicine and Rehabilitation, School of Medicine, Kyung Hee University, Seoul, Republic of Korea, Ginseng and Medical Plants Research Institute Rural Development Administration, Chunbuk 369-873, Republic of Korea
- Published online on: October 21, 2011 https://doi.org/10.3892/etm.2011.372
-
Pages:
93-98
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Abstract
Insulin-like growth factor 1 (IFG1) is neuroprotective in animal models of focal brain ischemia and correlates with ischemic stroke (IS) outcome in the elderly. In this study, we investigated whether single nucleotide polymorphisms (SNPs) of the IFG1 gene are associated with the development and clinical features of IS in a Korean population. A total of 119 patients with IS and 289 control subjects were recruited. Stroke patients were classified into subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS; <6 and ≥6) and the Modified Barthel Index (MBI; <60 and ≥60). Among the SNPs of the IFG1 gene, five SNPs were selected and analyzed by direct sequencing: rs2162679 (intron), rs2195239 (intron), rs978458 (intron), rs1520220 (intron) and rs6214 (3' untranslated region; 3'UTR). Multiple logistic regression models were conducted to analyze genetic data. SNPStats, SNPAnalyzer Pro and Helixtree programs were used to calculate odds ratios (ORs), 95% confidence intervals (CIs) and p-values. Two SNPs, rs2162679 and rs6214, were associated with the development of IS. After Bonferroni correction (pc), the A and G alleles of rs2162679 and rs6214 had significant differences between patients with IS and the controls [rs2162679, OR (95% CI) = 1.64 (1.17-2.31), p=0.004, pc=0.02; rs6214, OR (95% CI) = 1.52 (1.12-2.07), p=0.007, pc=0.035], respectively. However, the five selected SNPs were not related to the NIHSS and MBI scores. These results suggest that IGF1 may be associated with the development of IS.
View References
|
1.
|
RA GrysiewiczK ThomasDK PandeyEpidemiology
of ischemic and hemorrhagic stroke: incidence, prevalence,
mortality, and risk factorsNeurol
Clin26871895200810.1016/j.ncl.2008.07.00319026895
|
|
2.
|
CJ Van AschMJ LuitseGJ RinkelIncidence,
case fatality, and functional outcome of intracerebral haemorrhage
over time, according to age, sex, and ethnic origin: a systematic
review and meta-analysisLancet Neurol9167176201020056489
|
|
3.
|
HM TaoGZ ChenXD LuGP ChenB ShaoTGF-beta1
869T/C polymorphism and ischemic stroke: sex difference in
ChineseCan J Neurol Sci37803807201021059542
|
|
4.
|
Y TongY GengJ XuThe role of functional
polymorphisms of the TNF-alpha gene promoter in the risk of
ischemic stroke in Chinese Han and Uyghur populations: two
case-control studiesClin Chim
Acta41112911295201010.1016/j.cca.2010.05.00720493182
|
|
5.
|
YH LimYS JeongSK KimAssociation between
TGFBR2 gene polymorphism (rs2228048, Asn389Asn) and intracerebral
hemorrhage in Korean PopulationImmunol
Invest40569580201110.3109/08820139.2011.55949821609163
|
|
6.
|
S KalmijnJA JanssenHA PolsSW LambertsMM
BretelerA prospective study on circulating insulin-like growth
factor I (IGF-I), IGF-binding proteins, and cognitive function in
the elderlyJ Clin Endocrinol
Metab8545514555200010.1210/jcem.85.12.703311134107
|
|
7.
|
M TagamiK YamagataY NaraInsulin-like
growth factors prevent apoptosis in cortical neurons isolated from
stroke-prone spontaneously hypertensive ratsLab
Invest7660361219979166279
|
|
8.
|
C GalliO MeucciA ScorzielloApoptosis in
cerebellar granule cells is blocked by high KCl, forskolin, and
IGF-1 through distinct mechanisms of action: the involvement of
intracellular calcium and RNA synthesisJ
Neurosci151172117919957532699
|
|
9.
|
R KooijmanS SarreY MichotteJ De
KeyserInsulin-like growth factor I: a potential neuroprotective
compound for the treatment of acute ischemic
stroke?Stroke40e83e88200910.1161/STROKEAHA.108.52835619197073
|
|
10.
|
J GuanAJ GunnES SirimanneThe window of
opportunity for neuronal rescue with insulin-like growth factor-1
after hypoxia-ischemia in rats is critically modulated by cerebral
temperature during recoveryJ Cereb Blood Flow
Metab20513519200010.1097/00004647-200003000-0001010724116
|
|
11.
|
A De SmedtR BrounsM
UyttenboogaartInsulin-like growth factor I serum levels influence
ischemic stroke outcomeStroke4221802185201121700939
|
|
12.
|
M BondanelliMR AmbrosioA OnofriPredictive
value of circulating insulin-like growth factor I levels in
ischemic stroke outcomeJ Clin Endocrinol
Metab9139283934200610.1210/jc.2006-104016882751
|
|
13.
|
M HenningsonM HietalaT TorngrenH OlssonH
JernstromIGF1 htSNPs in relation to IGF-1 levels in young women
from high-risk breast cancer families: implications for early-onset
breast cancerFam
Cancer10173185201010.1007/s10689-010-9404-z21113804
|
|
14.
|
WH HahnJS SuhBS ChoPolymorphisms of
insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R)
contribute to pathologic progression in childhood IgA
nephropathyGrowth
Factors29813201010.3109/08977194.2010.53212621047277
|
|
15.
|
AR McElholmAJ McKnightCC PattersonA
population-based study of IGF axis polymorphisms and the esophageal
inflammation, metaplasia, adenocarcinoma
sequenceGastroenterology139204212201010.1053/j.gastro.2010.04.01420403354
|
|
16.
|
SK KimHJ ParkJS LeeAssociation of
niemann-pick disease, type c2 (NPC2) polymorphisms with obesity in
Korean populationMol Cell Toxicol63954002010
|
|
17.
|
TW LimSK KimJY BanPolymorphisms of
transmembrane channel-like 1 gene are associated with Kawasaki
disease in Korean populationMol Cell Toxicol52912972009
|
|
18.
|
P GluckmanN KlemptJ GuanA role for IGF-1
in the rescue of CNS neurons following hypoxic-ischemic
injuryBiochem Biophys Res
Commun182593599199210.1016/0006-291X(92)91774-K1370886
|
|
19.
|
XF LiuJR FawcettRG ThorneWH Frey
IINon-invasive intranasal insulin-like growth factor-I reduces
infarct volume and improves neurologic function in rats following
middle cerebral artery occlusionNeurosci Lett30891942001
|
|
20.
|
E FeikA BaierlB HiegerAssociation of IGF1
and IGFBP3 polymorphisms with colorectal polyps and colorectal
cancer riskCancer Causes
Control219197201010.1007/s10552-009-9438-419784788
|
