Association between cytochrome P450 promoter polymorphisms and ischemic stroke

  • Authors:
    • Su Kang Kim
    • Sung-Vin Yim
    • Byung-Cheol Lee
  • View Affiliations

  • Published online on: November 22, 2011     https://doi.org/10.3892/etm.2011.388
  • Pages: 261-268
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Abstract

The human cytochrome P450 (CYP) superfamily includes at least 57 genes that encode enzymes with diverse metabolic and biosynthetic functions. This study was conducted in order to investigate the associations between polymorphisms in CYP superfamily genes (CYP11B2, CYP17A1, CYP2B6, CYP2C9, CYP2E1 and CYP7A1) and ischemic stroke (IS). Six single nucleotide polymorphisms (SNPs) of CYP superfamily genes were selected and genotyped by direct sequencing in 121 patients with IS and 321 control subjects. The genetic data were analyzed using SNPStats and SPSS 18.0. Multiple logistic regression models (codominant 1, codominant 2, dominant, recessive and log-additive) were used to evaluate odds ratios (ORs), 95% confidence intervals (CIs) and p-values. The rs179998 SNP of CYP11B2 was significantly associated with IS (p=0.0336 in a log-additive model). The rs3813867 SNP of CYP2E1 was significantly associated with smoking in IS (p=0.0336 in a log-additive model). The rs1799998 SNP of CYP11B2 and rs3808607 of CYP7A1 were related to diabetes mellitus in IS (p<0.05). CYP11B2, CYP2E1 and CYP7A1 SNPs were associated with IS in the population studied. Further study is required to confirm these associations and to determine their biological significance.
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February 2012
Volume 3 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Kim S, Yim S and Lee B: Association between cytochrome P450 promoter polymorphisms and ischemic stroke. Exp Ther Med 3: 261-268, 2012.
APA
Kim, S., Yim, S., & Lee, B. (2012). Association between cytochrome P450 promoter polymorphisms and ischemic stroke. Experimental and Therapeutic Medicine, 3, 261-268. https://doi.org/10.3892/etm.2011.388
MLA
Kim, S., Yim, S., Lee, B."Association between cytochrome P450 promoter polymorphisms and ischemic stroke". Experimental and Therapeutic Medicine 3.2 (2012): 261-268.
Chicago
Kim, S., Yim, S., Lee, B."Association between cytochrome P450 promoter polymorphisms and ischemic stroke". Experimental and Therapeutic Medicine 3, no. 2 (2012): 261-268. https://doi.org/10.3892/etm.2011.388