CREST biorepository for translational studies on malignant mesothelioma, lung cancer and other respiratory tract diseases: Informatics infrastructure and standardized annotation

Ugolini,Donatella; Neri,Monica; Bennati,Luca; Canessa,Pier Aldo; Casanova,Georgia; Lando,Cecilia; Leoncini,Giacomo; Marroni,Paola; Parodi,Barbara; Simonassi,Claudio; Bonassi,Stefano

doi:10.3892/etm.2011.416

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article

CREST biorepository for translational studies on malignant mesothelioma, lung cancer and other respiratory tract diseases: Informatics infrastructure and standardized annotation

Authors:
- Donatella Ugolini
- Monica Neri
- Luca Bennati
- Pier Aldo Canessa
- Georgia Casanova
- Cecilia Lando
- Giacomo Leoncini
- Paola Marroni
- Barbara Parodi
- Claudio Simonassi
- Stefano Bonassi
View Affiliations / Copyright

Affiliations: Department of Oncology, Biology and Genetics, University of Genoa, National Cancer Research Institute, 10-16132 Genoa, Italy, Unit of Rehabilitative Pneumology, San Raffaele Pisana, Rome, Italy, Unit of Pneumology, Ospedale San Bartolomeo, Sarzana, Italy, Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy, Unit of Thoracic Surgery, Azienda Ospedaliera Universitaria San Martino, Genoa, Italy, Unit of Clinical Pathology, National Cancer Research Institute, Genoa, Italy, Biological Bank and Cell Factory, National Cancer Research Institute, Genoa, Italy, Unit of Pneumology, Azienda Ospedaliera Villa Scassi, Genoa, Italy, Unit of Clinical and Molecular Epidemiology, San Raffaele Pisana, Rome, Italy
Pages: 540-546
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Published online on: December 14, 2011

https://doi.org/10.3892/etm.2011.416
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Abstract

Advances in molecular epidemiology and translational research have led to the need for biospecimen collection. The Cancer of the Respiratory Tract (CREST) biorepository is concerned with pleural malignant mesothelioma (MM) and lung cancer (LC). The biorepository staff has collected demographic and epidemiological data directly from consenting subjects using a structured questionnaire, in agreement with The Public Population Project in Genomics (P³G). Clinical and follow-up data were collected. Sample data were also recorded. The architecture is based on a database designed with Microsoft Access. Data standardization was carried out to conform with established conventions or procedures. As from January 31, 2011, the overall number of recruited subjects was 1,857 (454 LC, 245 MM, 130 other cancers and 1,028 controls). Due to its infrastructure, CREST was able to join international projects, sharing samples and/or data with other research groups in the field. The data management system allows CREST to be involved, through a minimum data set, in the national project for the construction of the Italian network of Oncologic BioBanks (RIBBO), and in the infrastructure of a pan-European biobank network (BBMRI). The CREST biorepository is a valuable tool for translational studies on respiratory tract diseases, because of its simple and efficient infrastructure.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

CREST biorepository for translational studies on malignant mesothelioma, lung cancer and other respiratory tract diseases: Informatics infrastructure and standardized annotation

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