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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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March 2012 Volume 3 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules

  • Authors:
    • Shoichiro Ohta
    • Yukiko Cho
    • Masaharu Shibata
    • Kimihiro Nagai
    • Tatsuo Iijima
    • Hitoaki Saito
    • Hirotaka Asakura
    • Hiroshi Kojima

  • View Affiliations / Copyright

    Affiliations: Ibaraki Prefectural Central Hospital, Ibaraki Prefectural Cancer Center, Ibaraki, Japan, Saitama Medical University, Saitama, Japan
  • Pages: 547-549
    |
    Published online on: December 14, 2011
       https://doi.org/10.3892/etm.2011.417
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Abstract

Recently, antibody-mediated epidermal growth factor receptor (EGFR) blockade has become a major research focus, and a number of clinical studies on this new treatment have been started in the field of clinical oncology. This retrospective study investigated the role of KRAS gene mutations and clinical features for possibilities for new therapies in patients with cancer of unknown primary (CUP). We investigated the role of KRAS, PIK3CA and BRAF gene mutations and clinical features for possibilities for new therapies in patients with CUP. Nine patients with metastases from an unknown primary tumor were included in this retrospective study. The KRAS, BRAF and PI3KCA mutational analyses were carried out by means of PCR using genomic DNA for each PCR reaction. The mutation rate in CUP for codon 12 or 13 of the KRAS gene and for PIK3CA was lower than that in colorectal cancer, while the same mutation rate for BRAF was almost the same in the two; this means that the EGFR antibodies can possibly treat CUP.
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Copy and paste a formatted citation
Spandidos Publications style
Ohta S, Cho Y, Shibata M, Nagai K, Iijima T, Saito H, Asakura H and Kojima H: Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules. Exp Ther Med 3: 547-549, 2012.
APA
Ohta, S., Cho, Y., Shibata, M., Nagai, K., Iijima, T., Saito, H. ... Kojima, H. (2012). Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules. Experimental and Therapeutic Medicine, 3, 547-549. https://doi.org/10.3892/etm.2011.417
MLA
Ohta, S., Cho, Y., Shibata, M., Nagai, K., Iijima, T., Saito, H., Asakura, H., Kojima, H."Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules". Experimental and Therapeutic Medicine 3.3 (2012): 547-549.
Chicago
Ohta, S., Cho, Y., Shibata, M., Nagai, K., Iijima, T., Saito, H., Asakura, H., Kojima, H."Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules". Experimental and Therapeutic Medicine 3, no. 3 (2012): 547-549. https://doi.org/10.3892/etm.2011.417
Copy and paste a formatted citation
x
Spandidos Publications style
Ohta S, Cho Y, Shibata M, Nagai K, Iijima T, Saito H, Asakura H and Kojima H: Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules. Exp Ther Med 3: 547-549, 2012.
APA
Ohta, S., Cho, Y., Shibata, M., Nagai, K., Iijima, T., Saito, H. ... Kojima, H. (2012). Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules. Experimental and Therapeutic Medicine, 3, 547-549. https://doi.org/10.3892/etm.2011.417
MLA
Ohta, S., Cho, Y., Shibata, M., Nagai, K., Iijima, T., Saito, H., Asakura, H., Kojima, H."Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules". Experimental and Therapeutic Medicine 3.3 (2012): 547-549.
Chicago
Ohta, S., Cho, Y., Shibata, M., Nagai, K., Iijima, T., Saito, H., Asakura, H., Kojima, H."Possibility of molecular targeting therapy for the treatment of cancer of unknown primary origin by analysis of intracellular signaling molecules". Experimental and Therapeutic Medicine 3, no. 3 (2012): 547-549. https://doi.org/10.3892/etm.2011.417
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