TNF-α -863 polymorphisms and the risk of hepatocellular carcinoma

Yang,Yan; Qiu,Xiao-Qiang; Yu,Hong-Ping; Zeng,Xiao-Yun; Bei,Chun-Hua

doi:10.3892/etm.2011.418

March 2012 Volume 3 Issue 3

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

March 2012 Volume 3 Issue 3

Full Size Image

Article

TNF-α -863 polymorphisms and the risk of hepatocellular carcinoma

Authors:
- Yan Yang
- Xiao-Qiang Qiu
- Hong-Ping Yu
- Xiao-Yun Zeng
- Chun-Hua Bei
View Affiliations / Copyright

Affiliations: Department of Epidemiology, School of Public Health, Guangxi Medical University, Nanning, P.R. China, School of Public Health, Guilin Medical University, Guilin, Guangxi, P.R. China
Pages: 513-518
|
Published online on: December 15, 2011

https://doi.org/10.3892/etm.2011.418
Expand metrics +

Abstract

Hepatocellular carcinoma (HCC) is a common type of highly malignant tumor. Guangxi is an area of China characterized by a high incidence of HCC. Previous epidemiological studies have found that chronic infection with hepatitis B virus (HBV) is one of the major etiological risk factors for HCC in China. With the increased understanding of the host immune response against HBV and the pathogenesis of the virus, at present, greater attention is being given to the immune response of cytokine genes, as polymorphisms may have a major impact on the course and outcome of HBV infection. In the present study, we genotyped tumor necrosis factor-α (TNF-α) rs1800629 (-308G/A), rs1800630 (-863C/A); interleukin-1B rs1143627 (-31T/C); and transforming growth factor β1 (TGF-β1) rs1800469 (-509C/T) in a hospital-based study of 772 HCC cases and 852 cancer-free controls. The distribution of the frequency of TNF-α rs1800630 sites of CC, CA, AA were 65.67, 27.46 and 6.87% in the case group, respectively, as compared with 67.02, 29.58 and 3.40% in the controls, all with a statistical significance (P<0.05). The logistic regression analysis revealed that the variant rs1800630 AA genotypes were associated with a significantly increasing risk of HCC (OR=2.058, 95% CI 1.289-3.287), compared with the wild-type rs1800630 CC. Further stratified analyses showed that after stratification for history of alcohol drinking, in a subgroup of individuals without a history of drinking, the HCC risk in the group with the TNF-α rs1800630 A allele was 1.839 times higher than that in the group with TNF-α rs1800630 C (P<0.010). These findings suggest that TNF-α rs1800630 may contribute to the risk of HCC, however, these data require further validation.

View Figures

View References

1.	DM ParkinF BrayJ FerlayP PisaniGlobal cancer statistics, 2002CA Cancer J Clin5574108200510.3322/canjclin.55.2.74
2.	MJ ThunJO DeLanceyMM CenterThe global burden of cancer: priorities for preventionCarcinogenesis31100110201010.1093/carcin/bgp26319934210
3.	C ZhangT HuangJ YuEpidemiological analysis of primary liver cancer in the early 21st century in Guangxi province of ChinaChin J Cancer29545550201010.5732/cjc.009.10510
4.	FS YehKN ShenEpidemiology and early diagnosis of primary liver cancer in ChinaAdv Cancer Res47297329198610.1016/S0065-230X(08)60203-12430432
5.	JD GroopmanJS WangP SchollMolecular biomarkers for aflatoxins: from adducts to gene mutations to human liver cancerCan J Physiol Pharmacol7420320919968723033
6.	V ThakurRC GuptanSN KazimProfile, sepectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinentJ Gastroenterol Hepatol17165170200210.1046/j.1440-1746.2002.02605.x11966946
7.	AS LokEJ HeathcoteJH HoofnaqueManagement of hepatitis B: 2000-summary of a workshopGastroenterology12018281853200110.1053/gast.2001.2483911375963
8.	S InoNatural history of hepatitis B and C virus infectionOncology621823200210.1159/000048271
9.	A BudhuXW WangThe role of cytokines in hepatocellular carcinomaJ Leukoc Biol8011971213200610.1189/jlb.050629716946019
10.	C FerrariA PennaA BertolettiAntiviral cell-mediated immune responses during hepatitis B and hepatitis C virus infectionsRecent Results Cancer Res154330336199810.1007/978-3-642-46870-4_2410027013
11.	GN VgasImmunobiology of persistent blood-borne viral infectionsDev Biol102917200010794086
12.	SY HoYJ WangHL ChenIncreased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-α promoter geneCancer Causes Control15657663200415280623
13.	Y WangN KatoY HoshidaInterleukin-1B gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infectionHepatology376571200310.1053/jhep.2003.5001712500190
14.	YJ KimHS LeeJP ImAssociation of transforming growth factor-beta1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infectionExp Mol Med35196202200310.1038/emm.2003.2712858019
15.	P QiYM ChenH Wang-509C>T polymorphism in the TGF-β1 gene promoter, impact on the hepatocellular carcinoma risk in Chinese patients with chronic hepatitis B virus infectionCancer Immunol Immunother58143314402009
16.	T SkoogFM HooftB KallinA common functional polymorphism (C→A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alphaHum Mol Genet8144314491999
17.	PC KaoJF WuYH NiTumour necrosis factor-alpha promoter region polymorphisms affect the course of spontaneous HBsAg clearanceLiver Int3014481453201010.1111/j.1478-3231.2010.02340.x
18.	P KummeeP TangkijvanichY PoovorawanAssociation of HLA-DRB1^*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai populationJ Viral Hepat14841848200718070287
19.	Q XiaL ZhouD LiuRelationship between TNF-<alpha> gene promoter polymorphisms and outcomes of hepatitis B virus infections: a meta-analysisPLoS One6e196062011

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

TNF-α -863 polymorphisms and the risk of hepatocellular carcinoma

This article is mentioned in:

Abstract

Related Articles