Ectopic expression of RASSF2 and its prognostic role for gastric adenocarcinoma patients

Luo,Deng; Ye,Ting; Li,Tian-Qian; Tang,Peng; Min,Sha-Dong; Zhao,Gong-Fang; Huang,Hua; Chang,Jiang; Wang,Yan; Lv,Lin; Lu,Ming-Liang; Zheng,Meng-Yao

doi:10.3892/etm.2011.440

March 2012 Volume 3 Issue 3

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March 2012 Volume 3 Issue 3

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Article Open Access

Ectopic expression of RASSF2 and its prognostic role for gastric adenocarcinoma patients

Authors:
- Deng Luo
- Ting Ye
- Tian-Qian Li
- Peng Tang
- Sha-Dong Min
- Gong-Fang Zhao
- Hua Huang
- Jiang Chang
- Yan Wang
- Lin Lv
- Ming-Liang Lu
- Meng-Yao Zheng
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, Department of Oncology, Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650101, P.R. China, Department of Pathology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China, Institute of Pharmacological Research, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P.R. China
Pages: 391-396
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Published online on: December 28, 2011

https://doi.org/10.3892/etm.2011.440
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Abstract

RASSF2 has recently been identified as a potential tumor suppressor that serves as a Ras effector in various types of human cancers. However, there have been few reports detailing this in gastric cancer. Samples of gastric adenocarcinoma from 276 Chinese patients with follow-up were analyzed for RASSF2 protein expression by immunohistochemistry. RASSF2 was expressed in up to 31.2% (86/276) of this group of gastric carcinoma. The expression of RASSF2 was significantly lower in carcinomas than in normal mucosas (P<0.05). RASSF2 corresponded positively with patient age, histological differentiation, depth of tumor invasion, regional lymph node and distant metastasis, and TNM stage (all P<0.05). Further multivariate analysis revealed that patient gender, depth of tumor invasion, distant metastasis, TNM stage and the expression of RASSF2 were independent prognostic factors for patients with gastric cancer. The Kaplan-Meier plot showed that the overall mean survival time of the patients with RASSF2-negative expression was shorter than that of patients with positive expression (χ2=156.874, P<0.0001). Moreover, RASSF2-negative expression had a much more significant effect on the survival of those patients with early stage tumors (χ2=127.167, P<0.0001), highlighted by a >50.9% reduction in 3-year survival compared to that of patients with RASSF2-positive expression. In late stages, the difference was also significant (χ2=6.246, P=0.019), with a 35.5% reduction in 3-year survival. It is suggested that RASSF2 plays an important role in the evolution of gastric adenocarcinoma and should be considered as a potential marker for its prognosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ectopic expression of RASSF2 and its prognostic role for gastric adenocarcinoma patients

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