Hyalinizing trabecular tumor of the thyroid: Case report and review of the literature

Li,Jing; Yang,Guang-Zhi; Gao,Lan-Xiang; Yan,Wen-Xiu; Jin,Hua; Li,Lin

doi:10.3892/etm.2012.529

Hyalinizing trabecular tumor of the thyroid: Case report and review of the literature

Authors:
- Jing Li
- Guang-Zhi Yang
- Lan-Xiang Gao
- Wen-Xiu Yan
- Hua Jin
- Lin Li
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Affiliations: Department of Pathology, The General Hospital of Beijing Military Command, Beijing 100700, P.R. China, Department of Pathology, The Eighth People's Hospital of Qingdao City, Qingdao, Shandong 266100, P.R. China, Department of Pathology, The 263rd Hospital of PLA, Beijing 101149, P.R. China
Published online on: March 28, 2012 https://doi.org/10.3892/etm.2012.529
Pages: 1015-1017

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Abstract

In 1987, Carney et al described a rare thyroid tumor termed hyalinizing trabecular adenoma presenting characteristics consisting of a trabecular growth pattern and hyalinizing stroma. In subsequent reports, the observed nuclear features and RET alterations led this tumor to be linked to papillary carcinoma. Subsequent reports concerning hyalinizing trabecular carcinoma further complicated its classification. To avoid uncertainties, the definition of hyalinizing trabecular tumor (HTT) is more widely used. Herein, a case of HTT is reported in detail, and the circumstances are also discussed. HTT is thought to be particularly differentiated from papillary carcinoma despite the identical high frequency of nuclear grooves and cytoplasmic inclusions, and MIB-1-positive staining is one of the most accurate diagnostic methods due to the distinct membrane-positive pattern noted in HTT. It is believed that most HTTs are benign and lobectomy is the standard treatment. Pathologists should offer surgeons information concerning diagnosis overlapping with effective treatment.

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