Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer

  • Authors:
    • She-Juan An
    • Qiu-Xiong Lin
    • Zhi-Hong Chen
    • Jian Su
    • Hua Cheng
    • Zhi Xie
    • Xu-Chao Zhang
    • Hai-Yu Zhou
    • Ying Huang
    • Shi-Liang Chen
    • Wei-Bang Guo
    • Yi-Long Wu
  • View Affiliations

  • Published online on: May 16, 2012     https://doi.org/10.3892/etm.2012.577
  • Pages: 226-230
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Abstract

Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. This study explored the expression of Ln5 and the role of its relationships with PTEN, phospho-EGFR (p-EGFR) and phospho-Akt (p-Akt) in the prognosis of patients with non-small cell lung cancer (NSCLC). The protein expression of Ln5, PTEN, p-EGFR and p-Akt was assessed by immunohistochemical analysis, and their relationships to prognosis were analyzed. Protein expression of Ln5, p-EGFR and p-Akt was detected in 61.2 (60/98), 60.2 (59/98) and 45.3% (43/95) of patients with NSCLC, respectively. Loss of PTEN expression was found in 67.7% of tumors (65/96). Ln5 expression was related to patient gender, histology and p-Akt expression (χ2=3.901, 4.549 and 6.985, respectively; P=0.048, 0.033 and 0.008, respectively). Patients with positive Ln5 expression had marginally poorer survival than Ln5-negative patients (median survival time 56.4 months vs. not reached; χ2=3.346; P=0.067). Overall survival was significantly different in patients with positive Ln5 expression combined with loss of PTEN, positive p-EGFR expression or positive p-Akt expression. Cox regression analysis showed that stage, co-expression of Ln5 and p-Akt, and PTEN were the three most independent prognostic factors for patients with NSCLC (χ2=27.906; P<0.0005). The results highlight the complex relationships between extracellular matrix proteins and key signaling pathway molecules in tumorigenesis. Changes in the expression of Ln5 plus PTEN, p-EGFR or p-Akt define a distinct subset of lung cancers. Patients with such cancers have poorer survival and require early treatment that impacts survival.
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August 2012
Volume 4 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
An S, Lin Q, Chen Z, Su J, Cheng H, Xie Z, Zhang X, Zhou H, Huang Y, Chen S, Chen S, et al: Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer. Exp Ther Med 4: 226-230, 2012.
APA
An, S., Lin, Q., Chen, Z., Su, J., Cheng, H., Xie, Z. ... Wu, Y. (2012). Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer. Experimental and Therapeutic Medicine, 4, 226-230. https://doi.org/10.3892/etm.2012.577
MLA
An, S., Lin, Q., Chen, Z., Su, J., Cheng, H., Xie, Z., Zhang, X., Zhou, H., Huang, Y., Chen, S., Guo, W., Wu, Y."Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer". Experimental and Therapeutic Medicine 4.2 (2012): 226-230.
Chicago
An, S., Lin, Q., Chen, Z., Su, J., Cheng, H., Xie, Z., Zhang, X., Zhou, H., Huang, Y., Chen, S., Guo, W., Wu, Y."Combinations of laminin 5 with PTEN, p-EGFR and p-Akt define a group of distinct molecular subsets indicative of poor prognosis in patients with non-small cell lung cancer". Experimental and Therapeutic Medicine 4, no. 2 (2012): 226-230. https://doi.org/10.3892/etm.2012.577