Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases

Bae,Gi-Sang; Park,Kyoung-Chel; Koo,Bon  Soon; Jo,Il-Joo; Choi,Sun  Bok; Song,Ho-Joon; Park,Sung-Joo

doi:10.3892/etm.2012.612

Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases

Authors:
- Gi-Sang Bae
- Kyoung-Chel Park
- Bon Soon Koo
- Il-Joo Jo
- Sun Bok Choi
- Ho-Joon Song
- Sung-Joo Park
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Affiliations: Hanbang Body-Fluid Research Center, Wonkwang University, Iksan, Jeonbuk 540-749, Republic of Korea, Department of Herbology, School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 540-749, Republic of Korea
Published online on: June 18, 2012 https://doi.org/10.3892/etm.2012.612
Pages: 533-537

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Abstract

Previously, we reported that Nardostachys jatamansi (NJ) attenuated cerulein-induced mild acute pancreatitis (AP). In the present study, we investigated the ability of NJ to ameliorate severe acute pancreatitis (SAP) induced by a choline-deficient diet supplemented with ethionine (CDE). An NJ extract was orally administered ad libitum via the water during administration of the CDE. After three days, the CDE was replaced with a normal diet. After four days of normal feeding the mice were sacrificed and the blood and pancreas were obtained for further investigation. NJ treatment reduced SAP-induced pancreatic damage, as shown by histology. NJ treatment also inhibited neutrophil infiltration into the pancreas. NJ also inhibited the secretion of digestive enzymes and cytokine production, and inhibited the activation of mitogen‑activated protein kinases (MAPKs) in the SAP-challenged pancreas. These data suggest that NJ protects against pancreatic injury in CDE-induced SAP by deactivating MAPKs.

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