Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice

He,Chang-Sheng; Yue,Hong-Yi; Xu,Jian; Xue,Feng; Liu,Jian; Li,Yuan-Yuan; Jing,Hong-En

doi:10.3892/etm.2012.666

October 2012 Volume 4 Issue 4

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October 2012 Volume 4 Issue 4

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Article

Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice

Authors:
- Chang-Sheng He
- Hong-Yi Yue
- Jian Xu
- Feng Xue
- Jian Liu
- Yuan-Yuan Li
- Hong-En Jing
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Affiliations: Department of Hepatobiliary Surgery, Jiaozhou Central Hospital of Qingdao, Qingdao, Shandong 266300, P.R. China, Department of Pediatrics, The First People's Hospital of Baoding City, Hebei, Baoding 071000, P.R. China, Department of Hepatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, P.R. China
Pages: 645-648
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Published online on: August 14, 2012

https://doi.org/10.3892/etm.2012.666
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Abstract

Obstructive jaundice is a condition caused by blockage of the flow of bile out of the liver. This results in an overflow of bile and its by-products into the blood, and bile excretion from the body is incomplete. Untreated, obstructive jaundice can lead to serious infection that spreads to other parts of the body. We examined the protective effect of capillary artemisia polysaccharide on oxidative damage to the liver in growing rats with obstructive jaundice (OJ). Growing male Wistar rats (n=40, age 3-4 weeks) were randomly divided into four groups (n=10 in each group): normal control group, sham group, OJ group and OJ with capillary artimesia polysaccharide treatment group (study group). The rats of the OJ group and the study group were subjected to common bile dust ligation, while the sham group had the bile duct mobilized but not ligated. The rats of the study group recieved 5 ml/kg capillary artimesia polysaccharide (0.5 g/ml) by intraperitoneal (i.p.) injection once daily while the other groups were administered 5 ml/kg saline by i.p. injection. After 4 weeks, the rats were sacrificed to obtain liver weight and to compute the liver coefficient. Additional measures included liver homogenate malondialdehyde (MDA) and the activity levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The liver weight and liver coefficient of rats in the study group were lower than those in the OJ group and higher than those in the control and sham groups (P<0.05). Liver homogenate MDA content in the study group rats was lower than that in the OJ group and higher than that in the control and sham group (P<0.05). SOD, GSH-Px and CAT activities were higher in the study group rats than those in the OJ group and lower than those in other groups (P<0.05). Capillary artimesia capillary artemisia polysaccharide protects the liver from oxidative damage and improves antioxidant defense in growing rats with obstructive jaundice.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice

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