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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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October 2012 Volume 4 Issue 4

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Article

Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin

  • Authors:
    • Binou Yang
    • Weiqing Huang
    • Jieyun Han
    • Zijing Liang
  • View Affiliations / Copyright

    Affiliations: National Hepatobiliary and Enteric Surgery Research Center of Ministry of Health, Central South University, Changsha, Hunan 410008, P.R. China, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 611-614
    |
    Published online on: August 16, 2012
       https://doi.org/10.3892/etm.2012.670
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Abstract

The aim of this study was to investigate the effect of epidermal growth factor (EGF) on the lung fluid transport of rabbits with acute lung injury caused by endotoxin and evaluate its therapeutic action. A total of 24 rabbits were randomly divided into control, simple acute lung injury (ALI) and EGF only treatment groups. ALI rabbit models were constructed by the administration of endotoxin (lipopolysaccharide, LPS) and subsequent treatment with EGF. Arterial partial pressure of oxygen, lung pathomorphological changes and wet/dry weight (W/D) of the left lobe of lung tissue were observed at various time points. Results showed that following treatment with EGF, the breathing status of the rabbits continued to improve. An increase was noted in PaO2 at 12 h after EGF treatment and 24 h later PaO2 had significantly increased. A marked decrease was observed in the value of W/D and the exudation was reduced. The extrinsic EGF decreased the exudation of pulmonary capillaries and improved lung water transport. Our findings verified that epidermal growth factor had repaired the effect of ALI through continuous 48‑h observation. Therefore, the present study demonstrated the therapeutic action of EGF.
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Copy and paste a formatted citation
Spandidos Publications style
Yang B, Huang W, Han J and Liang Z: Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin. Exp Ther Med 4: 611-614, 2012.
APA
Yang, B., Huang, W., Han, J., & Liang, Z. (2012). Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin. Experimental and Therapeutic Medicine, 4, 611-614. https://doi.org/10.3892/etm.2012.670
MLA
Yang, B., Huang, W., Han, J., Liang, Z."Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin". Experimental and Therapeutic Medicine 4.4 (2012): 611-614.
Chicago
Yang, B., Huang, W., Han, J., Liang, Z."Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin". Experimental and Therapeutic Medicine 4, no. 4 (2012): 611-614. https://doi.org/10.3892/etm.2012.670
Copy and paste a formatted citation
x
Spandidos Publications style
Yang B, Huang W, Han J and Liang Z: Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin. Exp Ther Med 4: 611-614, 2012.
APA
Yang, B., Huang, W., Han, J., & Liang, Z. (2012). Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin. Experimental and Therapeutic Medicine, 4, 611-614. https://doi.org/10.3892/etm.2012.670
MLA
Yang, B., Huang, W., Han, J., Liang, Z."Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin". Experimental and Therapeutic Medicine 4.4 (2012): 611-614.
Chicago
Yang, B., Huang, W., Han, J., Liang, Z."Study of the role of epidermal growth factor on lung fluid transport in rabbits with acute lung injury caused by endotoxin". Experimental and Therapeutic Medicine 4, no. 4 (2012): 611-614. https://doi.org/10.3892/etm.2012.670
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