Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease

  • Authors:
    • Sheng-Lan Wang
    • Zhi-Rong Wang
    • Chang-Qing Yang
  • View Affiliations

  • Published online on: September 20, 2012     https://doi.org/10.3892/etm.2012.718
  • Pages: 1051-1056
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Abstract

Patients with Crohn's disease (CD) or ulcerative colitis (UC) undergo various therapies, including antibiotic therapy. This meta-analysis of controlled clinical trials was conducted to evaluate whether the use of antibacterial therapy improves the clinical symptoms of inflammatory bowel disease (IBD). The Medline and Scopus databases were searched and a systematic review was performed. Randomized, controlled trials in which antibiotic therapy was compared with placebo were investigated. A total of 10 randomized, placebo‑controlled clinical trials for CD were included in the meta-analysis. The pooling of the data from these trials yielded an odds ratio (OR) of 1.35 [95% confidence interval (CI), 1.16-1.58] for antibiotic therapy compared with placebo in patients with CD. Furthermore, nine randomized placebo-controlled clinical trials for UC matched our criteria and were included in the analysis. The pooling of the data from these trials yielded an OR of 2.17 (95% CI, 1.54-3.05) in favor of antibiotic therapy. These results suggest that antibiotics improve clinical outcomes in patients with IBD.
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December 2012
Volume 4 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang S, Wang Z and Yang C: Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease. Exp Ther Med 4: 1051-1056, 2012.
APA
Wang, S., Wang, Z., & Yang, C. (2012). Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease. Experimental and Therapeutic Medicine, 4, 1051-1056. https://doi.org/10.3892/etm.2012.718
MLA
Wang, S., Wang, Z., Yang, C."Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease". Experimental and Therapeutic Medicine 4.6 (2012): 1051-1056.
Chicago
Wang, S., Wang, Z., Yang, C."Meta-analysis of broad-spectrum antibiotic therapy in patients with active inflammatory bowel disease". Experimental and Therapeutic Medicine 4, no. 6 (2012): 1051-1056. https://doi.org/10.3892/etm.2012.718